Dohledat

Vitamin C

• Required for the proper synthesis of DS.

Dermatan sulfate (DS)

Mechanical forces

• Shear stress and compression
• Have been shown to affect the synthesis of DS.

Oxidative stress

• Imbalance between reactive oxygen species and antioxidant defenses
• Affect the synthesis of DS.

Microgravity

• Affects the synthesis of DS
• By altering the activity of enzymes involved in the synthesis of DS.

Hypoxia

• Low oxygen environment
• Affect the synthesis of DS.

Aging

• Decline in the synthesis of DS
• May lead to an alteration of the extracellular matrix that results in the development of pathologies.