Krevní cévy, kapiláry

VE-cadherin

Genetic deletion of VE-cadherin

• Leads to embryonic lethality
• Adherens junctions are essential for early steps of assembly of endothelial cells into blood vessels [47]

BV13 antibody to adults

• Causes dispersion of VE-cadherin away from junctions between endothelial cells of blood vessels
• Accompanied by fatal leakage and hemorrhage within hours of intravascular injection [47]