nemoci-sympt/LYMFOLOGIE/zmirnujici-faktory-otoku/LYMFOCHIRURGIE/implantaty-lymfaticke

Lymphatic grafting

Stem/progenitor cells as a delivery system

• To locally and durably release a complement of (lymph)angiogenic growth factors
• May overcome these caveats
• Stem/progenitor cells with limited capacity can differentiate down the lymphatic endothelial cell lineage
• Bone marrow-derived MAPCs
• Can undergo formation of arterial and venous endothelial cells
• Raise a robust angiogenic and arteriogenic response in ischaemic limbs and hearts, mainly by trophic support [39]
• Robustly contributed to restoration of a functional lymphatic system at the capillary and (pre-)collector level
• Mediated functional reintegration of transplanted lymph nodes !!! [39]