Patofyziologie

Estrogeny

• Increased cerebral blood flow (CBF) in participants with lipedema
• estrogen signaling
• Higher estrogen levels have been linked to increased carotid arterial blood flow

• Biomedicines 2022, 10, 3081

Estrogenní aktivita v souvislostech

Accelerated onset of puberty

• Predominantly affects females / people with uteruses / the current thing
• The age at which girls start to develop breasts
• One of the first physical signs of puberty
• Declined among white girls from 11 in the 1980’s to 10 in the mid-90’s
• Black girls showing a year earlier, at age 9
• Age of puberty in girls has dropped by about three months per decade since the 1970s
• Parallel but less extreme shifts have occurred in boys
• Diagnostic criteria for central precocious puberty, a rare hormonal syndrome triggered by lesions in the central nervous system
• May have to be re-drawn
• Age threshold between normal and precocious puberty, previously set at 8, should be lowered to ages 7 and 6 in white and black girls respectively

Girls who go through puberty early

• Greater risk of depression, anxiety, substance abuse and other psychological problems
• Higher risk of breast and uterine cancer in later life
• More at risk of early death - as are boys
• drpaulclayton.eu/blog/wasted-on-the-young/

Vyšší podíl poruch pohlaví mužů

• Těhotná žena a mozek jejího plodu vystaven vyššímu působení estrogenních látek během těhotenství
• Více mužů se změnou orientace
• Homosexuálně smýšlejících
• Trans-smýšlejících ap.
• Necítících se jako muži ap.

In circa 1950 - horší stav dnes

• At least four interacting factors predisposed to early puberty:
• Childhood obesity, which is obviously increasing
• Exposure to endocrine disruptors - also increasing
• Neuroinflammation
• Gut dysbiosis
• drpaulclayton.eu/blog/wasted-on-the-young/

Estrogen a histamin

• High estrogen stimulates mast cells to release histamine
• Estrogen suppresses histamine breakdown by
• Decreasing DAO
• Decreasing monoamine oxidase (MAO) activity
• Histamine increases luteinizing hormone (LH) which increases estrogen
• Perpetuates a vicious cycle where histamine increases LH, which increases estrogen, which increases histamine, which increase LH and so forth.

Ženy

• In women, if allergy symptoms increase in the middle of the menstrual cycle
• It is likely that estrogen is contributing to the problem.

Muži

• estrogen levels increase as they age
• Formation of breast tissue (gynecomastia)
• If their allergy symptoms increase as they age
• estrogen is most likely a contributing factor.

Decline in total fertility rates

• To well below 2.1
• The rate considered necessary to sustain population size
• Female infertility has become common, and males are falling into line.

Sperm counts

• Have fallen by 50-60% over the last half century
• Diet and the endocrine disruptors seem to be involved

Testosterone levels

• Have also declined
• Males are becoming less fertile, less masculine and less robust
• Diet and the endocrine disruptors seem to be involved

Micropenis

• Shrinkage of pre-pubertal penis size
• Micropenis
• Endocrine disruptors probable risk factors

Pre-pubertal crypto-orchidism

• Failure of the testes to descend
• Seems to be increasing

Hypospadia

• Increasing numbers
• Congenital anomaly in males which affect the penis and urethra.
• Can generally be surgically corrected
• But there are more serious issues at play here
• Endocrine disruptors are implicated in hypospadias

Testicular germ cell cancer

• Spectacular rise
• Maternal diet appears to be an important factor behind the rise in germ cell cancer
• More industrial diet is associated with greater risk
• https://drpaulclayton.eu/blog/wasted-on-the-young/