nemoci-sympt/ONKOLOGIE/nadory-kolorekta/zhorseni

Iron

• Reported to bind CDK1 directly
• Enhance its activity
• CDK1 phosphorylates JAK1
• To activate the JAK/STAT3 signaling pathway
• Promote colorectal tumorigenesis
• www.nature.com/articles/s41419-019-1528-y