Nádory kůže nemelanomové
Skin cancer is one of the tumors causing malignancies around the world, and its incidence is increasing alarmingly [196]. Skin cancer is believed to develop through co-carcinogenic effects, and many natural metabolites have been widely studied as anti-carcinogens. In particular, allyl sulfides including diallyl sulfide (DAS), diallyl disulfide (DADS), and diallyl trisulfide (DATS) have been reported to prevent the progression of skin cancer [197]. DAS was found to have anti-mutagenic properties against 7,12-dimethylbenz[a]anthracene (DMBA), a carcinogenic polycyclic aromatic hydrocarbon that induces DNA strand breaks in mouse skin [198]. Additionally, DAS induced apoptosis in DMBA-mediated mouse skin tumors through multiple mechanisms, including the up-regulation of tumor suppressor protein p53, its downstream proteins, and proapoptotic proteins such as Bax, and the reduction of Ras onco-protein expression [199,200]. Pomolic acid, a triterpenoid found in Polylepis racemosa, was reported to have cytotoxic effects on M-14 melanoma cells [167].Skin cancer Diallyl sulfide Reduction of DNA strand breaks in DMBA induced mouse skin EC: 25
Induction of apoptosis in DMBA-induced mouse skin tumors
Pomolic acid Cytotoxic effects against M-14 melanoma cells EC: 14.6
Nicotinamide
- Has been found to have a function in the prevention of nonmelanoma skin cancers, which are caused mostly by UV exposure (Chen et al., 2015).
- www.frontiersin.org/articles/10.3389/fchem.2022.948217/full
