Radioterapie
- Absorbed radiation doses per unit of body weight of pancreas tissue
- Typically 30 - 60 Gy [3]
- Po operaci ke zničení nádorových buněk, které mohou přetrvávat v oblasti původního ložiska
- Za účelem zmírnění bolestí, které mohou být spojeny s neodstranitelným tumorem.
- Trvá zpravidla více týdnů [5]
- Auxiliary (adjuvant) treatment after potentially curative surgery
- Controversial since the 1980s
- European Society for Medical Oncology:
- Adjuvant radiotherapy used for people enrolled in clinical trials [24]
- Continuing tendency for clinicians in the US to be more ready to use adjuvant radiotherapy than those in Europe
- Many clinical trials failed to settle the matter conclusively
- Radiotherapy may form part of treatment to attempt to shrink a tumor to a resectable state
- Use on unresectable tumors remains controversial
- Conflicting results from clinical trials [24]
Iodine-125 seed implantation in unresectable pancreatic cancers
- PMID: 31977258 DOI: 10.1080/09553002.2020.1704300
- Radioactive 125I seed implantation therapy
- Good alternative in non-resectable pancreatic cancer patients
- Small radioactive particles are implanted inside the tumor cells
- To produce the sustain effects
- Short radial distance
- Selective and efficient killing of cancer cells
- Without any significant injury to the neighboring cells
- CT scan or ultrasound-guided percutaneous seed implantation is preferred
- Offers shorter operative time, lesser bleeding, early recovery, lesser complications
- Radioactive 125I seed implantation
- Management of local tumor growth, pain palliation, and improvement in the life span
- Alone or in combination with cryotherapy, existing chemotherapy, bypass surgery or radiations
- Need to formulate a uniform dose and procedure
- pubmed.ncbi.nlm.nih.gov/31977258/
