Biomarkery nemoci a monitorace

CA125

• Glycoprotein involved in the protection of cell function and lubrication
• Often found in normal tissues such as ovarian epithelium and thoracoabdominal membrane
• Abnormally high expression in the serum of
• Endometrial cancer,
• Cervical cancer,
• Other tumors - common tumor marker
• CA125 also has an abnormal expression in patients with lung cancer
• Closely related to the efficacy of chemotherapy in patients with advanced SCLC
• www.hindawi.com/journals/cmmi/2022/3104879/

CEA

• Lower in normal people
• Synthesis is more in tumor cells
• Leads to the gradual increase of CEA levels in the blood of patients
• Concentration of CEA in different stages of tumor is different
• Without metastasis is lower than that in patients with metastasis
• The higher the tumor differentiation degree, the higher the concentration of CEA
• In this study, the serum indices of NSE, CA125, and CEA were visibly decreased after treatment
• Suggesting that the above indices were negatively correlated with the therapeutic efficacy
• Could be used as important indicators for monitoring the evaluation of therapeutic effect in advanced SCLC
• www.hindawi.com/journals/cmmi/2022/3104879/

• SCLC is a high-grade neuroendocrine tumor
• Commonly expresses neuroendocrine markers
• Chromogranin A,
• Synaptophysin
• Neural cell adhesion molecule 1 (NCAM1)
• www.mdpi.com/1422-0067/22/24/13508

Biomarkery uspěšnosti terapie

NSE

• Specific acidic protease in neurons and neuroendocrine cell
• Lower expression level in healthy people
• 69% of SCLC patients have a higher serum NSE level
• Related to the occurrence of multiple tumors such as medullary thyroid carcinoma, neuroblastoma, and melanoma
• www.hindawi.com/journals/cmmi/2022/3104879/