Genetika

Genetika

Epigenetika

Stimulace/inhibice apoptózy

Cellular Bcl-2/Bax ratio

• Bcl-2 is an anti-apoptotic gene that has the ability to block a wide variety of apoptotic signals (Sedlak et al. 1995) [48]
• Bcl-2associated X protein (Bax) [48]
• Another member of the Bcl-2 family [48]
• Has an apoptosis-stimulating effect (Sarbia et al. 1997) [48]
• Its ability to form Bcl-2-Bax heterodimers [48]
• Preventing the formation of Bax homodimers [48]
• Cellular Bcl-2/Bax ratio is a key factor in the regulation of apoptosis
• High Bcl-2/Bax ratio [48]
• Makes cells resistant to apoptotic stimuli [48]
• Lower ratio [48]
• Induces cell death (Sedlak et al. 1995) [48]