Bilharzie - schistosomy
Trichobilharzia regenti (Schistosomatidae)
- Active migration of T. regenti schistosomula through the mouse spinal cord
- Induced motor deficits in hindlimbs
- But did not affect the general locomotion or working memory
- Histological examination of the infected spinal cord
- Eosinophilic meningomyelitis
- Eosinophil-rich infiltrates entrapping the schistosomula
- Massive activation of the host immune response
- Striking upregulation of
- major histocompatibility complex II pathway
- M2-associated markers
- Arginase
- Chitinase-like
- Arginase also dominated the proteins found in the microdissected tissue
- no demyelination or blood-brain barrier alterations were noticed
- Remarkable disruption of neurophysiological functions not yet recorded
- DNA fragmentation at the host-schistosomulum interface
- Schistosomula antigens did not affect the viability of neurons and glial cells in vitro.
- Altered locomotion,
- Significant disruption of neurophysiological functions,
- Strong M2 polarization were the most prominent features of T. regenti neuroinvasion
PLOS Pathogens | https://doi.org/10.1371/journal.ppat.1010302 February 4, 2022
