Trichomonas vaginalis

In vitro activity of N-chlorotaurine (NCT) in combination with NH4Cl against Trichomonas vaginalis

• Trichomoniasis, caused by the protozoan Trichomonas vaginalis
• Usually treated with metronidazole
• Resistance is on the rise
• N-chlorotaurine (NCT), a new endogenous mild active chlorine compound for topical use
• Killed T. vaginalis in vitro within 15 min of treatment
• At a concentration of 55 mM (1%)
• Is well tolerated by human tissue
• Activity of NCT was further enhanced by addition of ammonium chloride (NH4Cl)
• A combination of 5.5 mM (0.1%) NCT plus 19 mM (0.1%) NH4Cl killed 100% of trichomonads within 5 min
• www.sciencedirect.com/science/article/pii/S0924857910004164?via%3Dihub

Typical symptoms

• Vaginitis and cervicitis in women
• Chronic prostatitis syndrome
• www.sciencedirect.com/science/article/pii/S0924857910004164?via%3Dihub