COPD - CHOPN - chronická bronchoobstrukční nemoc plicní
H2
- Hydrogen attenuated the levels of inflammatory cytokines and ROS
- Increased expressions of genes for
- Fibroblast growth factor receptor-4
- Vascular endothelial growth factor receptor-2,
- Heme oxygenase-1
- Provided a promising therapeutic strategy for bronchopulmonary dysplasia
- HRS pretreatment ameliorated cigarette smoking-induced
- Airway mucus production
- Airway epithelium damage in rats.
- Serious radiation exposure could lead to lung tissue fibrosis
- Would produce serious effect on the respiratory function.
- In Japan found that the hydrogen alleviated cell damage, levels of oxidative stress and apoptotic markers
- Avoiding the happening of fibrosis
- Intraperitoneal administration of HRS before reperfusion
- Protected the lung from I/R injury,
- Probably by inhibiting oxidative stress and improving antioxidant enzyme activities
Ivacaftor
- CFTR therapeutic
- Significantly improves airway cell function following perturbation with smoke extract (Sloane et al., 2012; Raju et al., 2016). With this solid foundation, Solomon et al. (2016) completed a pilot evaluation of ivacaftor in smokers with chronic obstructive pulmonary dysfunction (COPD): although the trial was underpowered and found no statistically significant effect, the authors reported that improvements in CFTR activity and respiratory symptoms were evident and encouraged a phase 2 trial that is currently underway (NCT03085485).
https://www.frontiersin.org/articles/10.3389/fphys.2020.583862/full
