nemoci-sympt/VIROLOGIE/enteroviry/podpurne

Guazuma ulmifolia LAM., Sterculiaceae

Malý až středně velký strom z čeledi slézovité
Rozšířený zejména na územích Karibiku, Jižní Ameriky, Střední Ameriky a Mexika.
Slouží jako důležité krmivo pro hospodářská zvířata. Plody jsou jedlé jak vařené tak i syrové.
Odvar ze sušené kůry a sušených plodů

Léčitelé v Guatemale připravují odvar z kůry na zánět žaludku a tlumí žaludeční bolesti
Pro podporu růstu vlasů
K likvidaci parazitů ve vlasech
K léčení různých kožních problémů

Originally developed as a capsid inhibitor for rhinovirus, and it was later found to be active against EV-D68 (Figure 2B). Pleconaril (1) failed in the clinical trial for the treatment of rhinovirus-induced common colds due to a lack of efficacy.25 The X-ray crystal structure of EV-D68 virion in complex with pleconaril (1) was solved at 2.32 A resolution (PDB: 4WM7) (Figure 2C).18 Pleconaril (1) fits in a hydrophobic drug-binding pocket in the canyon region located at the VP1 protein and protects the virion against thermal inactivation. It inhibits EV-D68 replication in cell culture with single-digit to submicromolar potency as shown by multiple studies (Table 1),26–28 and it is often used as a positive control compound in antiviral assays as well as in mechanistic studies. Pleconaril (1) is active against multiple EV-D68 strains tested. However, it was not active against the close-related EV-A71 virus.28, 29 Resistance to pleconaril (1) was mapped to VP1-V81A (V69A in the 4WM7 numbering), a residue that locates right above the benzene ring of pleconaril (1). Mutating a bulky valine to a smaller alanine is likely to diminish the hydrophobic interactions between VP1 and pleconaril (1), leading to drug resistance. However, the fitness of the VP1-V69A mutant virus was not studied, and it is not clear whether this drug resistant mutation might be a potential concern or not.
www.ncbi.nlm.nih.gov/pmc/articles/PMC8055446/

Is a capsid inhibitor
Recently demonstrated activity in an oral poliovirus vaccine human challenge model
pubmed.ncbi.nlm.nih.gov/25316866/

Adults were challenged with monovalent oral poliovirus type 1 vaccine (mOPV1)
Subsequently treated with capsid inhibitor pocapavir or placebo.
The time to virus negativity in stool was determined.
Treatment with pocapavir was safe and significantly accelerated virus clearance.
pubmed.ncbi.nlm.nih.gov/27932608/

Red grapes possess antibacterial and antiviral properties.
Antiviral properties are also useful to fight against the polio virus and herpes simplex virus.
www.stylecraze.com/articles/benefits-of-red-grapes-for-skin-hair-and-health/

Gemcitabine metabolite directly inhibited the ability of PV RNA polymerase to synthesize or elongate PV RNA
Because PV RNA polymerase is somehow conserved among species in the Picornaviridae family

Gemcitabine may be further developed as an attractive broad-spectrum antiviral for PV and others.