nemoci-sympt/VIROLOGIE/nipah/patofyziologie

Výskyt v organismu

• Viral antigens can be detected in the bronchi and alveoli
• Later stages of illness
• Lung endothelia
• The blood
• Freely or in host leukocyte-bound form
• Lungs, spleen, kidneys and brain are targeted
• Patient suffers from multiple organ failure

Ephrin-B2 (EFNB2) and ephrin-B3 (EFNB3)

• Main functional receptors for both NiV clades
• Presence of these receptors in many vertebrates
• Wide host range of henipaviruses
• These receptors are often located on the arterial endothelial cells
• Systematic nature of the infections
• www.ecdc.europa.eu/en/infectious-disease-topics/z-disease-list/nipah-virus-disease/factsheet-nipah-virus-disease