Cordyceps

Cordyceps militaris Mycomedica

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• Možná již nebude možné nabízet Cordyceps militaris jako doplněk stravy (zákaz EU)
• Ve formě 50% extrakt a BIO prášku bude nahrazen Cordycepsem sinensis

Cordyceps sinensis

• Fungus parasite that lives on caterpillars in China’s high mountain region
• Cordyceps cells are propagated in laboratories (Robbers & Tyler, 1999)
• Lethargy, chronic bronchitis, kidney disorders, male sexual dysfunction, anemia, liver dysfunction, and dizziness
• Cordyceps might be cytotoxic to cancer cells (Bok, Lermer, Chilton, Klingeman, & Towers, 1999; Kuo et al., 1994; Kuo, Tsai, Shiao, Chen, & Lin, 1996), especially lung carcinoma (Nakamura et al., 1999) and melanoma (Xu, Peng, Chen, & Chen, 1992)
• No adverse effects have been reported (Natural Medicines Comprehensive Database, 2004)
• Zhu, Halpern, and Jones (1998) used a dose of 3 g daily.

Herbs or Natural Products That Decrease Cancer Growth Part One of a Four-Part Series; Muriel J. Montbriand, PhD, RN; Downloaded on 08 28 2019. Single-user license only. Copyright 2019 by the Oncology Nursing Society. For permission to post online, reprint, adapt, or reuse, please email pubpermissions@ons.org

Synonyma

• Housenice čínská
• Cordyceps sinensis
• Caterpillar Fungus
• Caterpillar Mushroom
• Cs-4
• Champignon Chenille
• Chinese Caterpillar Fungus
• Dong Chong Xia Cao
• Dong Chong Zia Cao
• Hsia Ts'Ao Tung Ch'Ung
• Ophiocordyceps sinensis
• Tochukaso
• Vegetable Caterpillar [3]

Nomenklatura

• Cordyceps sinensis in 2007 by nuclear DNA sampling
• Unrelated to most of the rest of the members of the genus
• Renamed: Ophiocordyceps sinensis
• Placed in a new family: Ophiocordycipitaceae [2]
• Cordyceps unilateralis
• Také přejmenovám a přesunut [2]
• Other species previously included in the genus Cordyceps
• Placed in the genus Tolypocladium [2]
• Cordyceps and Metacordyceps spp.
• Teleomorphs of a number of anamorphic, entomopathogenic fungus "genera" such as:
• Beauveria (Cordyceps bassiana)
• Lecanicillium
• Metarhizium
• Nomuraea [2]

Popis

• Genus of ascomycete fungi (sac fungi)
• Includes about 400 species
• Most Cordyceps species are endoparasitoids
• Parasitic mainly on insects and other arthropods
• Entomopathogenic fungi [2]
• Few are parasitic on other fungi [2]
• Worldwide distribution
• More than 400 species described from Asia
• Notably Nepal, China, Japan, Bhutan, Korea, Vietnam, and Thailand [2]
• Abundant and diverse in humid temperate and tropical forests [2]

Životní cyklus

• Cordyceps fungus attacks a host
• Mycelium invades and eventually replaces the host tissue
• Elongated fruit body (ascocarp) may be
• Cylindrical
• Branched
• Complex shape [2]
• The ascocarp
• Bears many small, flask-shaped perithecia containing asci
• Contain thread-like ascospores
• Break into fragments
• Presumably infective [2]

• Housenice čínská
• Lives on certain caterpillars in the high mountain regions of China

Cordiceps

• Má být nejsilnější betaglukan
• Cordiceps sinensis - Housenice čínská
• Mumifikuje housenky
• Více účinná
• Jen někde v Himalájích ve 3800-6000 m n.m.
• Pěstované od 2001 kmen CS4 cordiceps sinensis
• Housenice červená - housenice militaris
• Méně účinná

Interakce

• Cyclophosphamide (Cytoxan, Neosar) interacts with CORDYCEPS
• Cordyceps seems to increase the immune system
• Might decrease the effectiveness of cyclophosphamide
• Some other medications include
• Azathioprine (Imuran)
• Basiliximab (Simulect)
• Cyclosporine (Neoral, Sandimmune)
• Daclizumab (Zenapax)
• Muromonab-CD3 (OKT3, Orthoclone OKT3)
• Mycophenolate (CellCept)
• Tacrolimus (FK506, Prograf)
• Sirolimus (Rapamune)
• Prednisone (Deltasone, Orasone)
• Corticosteroids (glucocorticoids) [3]

Možné nežádoucí účinky

• Cordyceps might cause the immune system to become more active:
• Multiple sclerosis (MS)
• Lupus (systemic lupus erythematosus, SLE)
• Rheumatoid arthritis (RA)
• Other conditions [3]

• Bleeding
• Might slow blood clotting
• Increase the risk of bleeding in people with bleeding disorders
• Might increase the risk of bleeding during surgery
• Stop taking cordyceps 2 weeks before surgery [3]

Tradiční použití

• Podpora výkonu
• Zkrácení fází regenerace
• Zlepšení odolnosti vůči stresu + Reishi, Hericium
• Podpora plodnosti a sexuálních funkcí (vč. libida)
• Podpora funkce ledvin
• Regulace štítné žlázy + Reishi, Agaricus
• Imunostimulace
• Pozvednutí lidské nálady
• Podpora funkce srdce + Reishi, Agaricus, Shiitake
• Podpora funkce plic + Reishi, Coriolus [1]

• Diabetes
• Zlepšení kvality spermií
• Impotence
• Předčasná ejakulace
• Zvyšuje hladinu testosteronu
• Astma (především u dětí),
• Přetrvávající kašel
• COPD, emfyzém, rozedma
• Alergická rýma
• Opakující se infekce močových cest
• únavy, vyčerpání
• Cirhózy,
• Hepatitidy
• Anti-aging účinky
• Virové či bakteriální infekce
• Osteoporóza
• + cholesterol
• Regenerace svalů
• Reguluje menstruaci (metrorrhagie, silná menstruace...)
• Stresové stavy,
• Aktivuje fagocytózu makrofágů
• Podporuje spánek (je-li málo energie),
• Ateroskleróza
• Arytmie
• Zvyšuje počet trombocytů (trombocytopenie po chemoterapiích)
• Borelióza
• Strach, deprese
• Alergie na spermie [1]

• Coughs, chronic bronchitis, respiratory disorders [3]
• Kidney disorders, nighttime urination [3]
• Male sexual problems [3]
• Anemia [3]
• Irregular heartbeat [3]
• High cholesterol [3]
• Liver disorders [3]
• Dizziness, weakness [3]
• Ringing in the ears [3]
• Unwanted weight loss [3]
• Opiumaddiction [3]

Ojedinělé malé studie nazančují

Kidney damage caused by amikracin

• Using cordyceps with the drug amikracin
• Might reduce kidney damage caused by the drug in older people [3]

Asthma

• Cordyceps alone can reduce asthma symptoms in adults
• Along with other herbs for 6 months does not reduce the need for medication or improve asthma symptoms in children.

Chemotherapy

• Cordyceps by mouth during or after chemotherapy
• Might improve quality of life and improve tolerance to the treatments.

Kidney damage by cyclosporine

• Cordyceps with cyclosporine can reduce kidney damage in people with kidney transplants.

Hepatitis B

• Cordyceps by mouth might improve liver function in people with hepatitis B
• Less effective than astragalus and polygonum (fo-ti) [3]

Sexual desire

• Specific cordyceps product (CordyMax Cs-4) daily for 40 days
• Can improve sex drive in people with low sex drive.

Kidney transplant

• Cordyceps (Bailing capsules) daily for up to 2 years together with conventional treatments
• Does not improve survival in people who received a kidney transplant
• Might reduce
• The need for some conventional treatments [3]
• Number of infections [3]
• Other complications [3]
• Twice daily for 9 months together with the blood pressure-lowering drug enalapril after a transplant
• Improves kidney function
• Slow the progression of the disease in patients with declining kidney function [3]

TCM

Charakteristika

• Teplota – teplá
• Chuť – sladká
• Tropismus – plíce, ledviny [1]

Účinky podle tradiční čínské medicíny:

• Doplňuje ledvinový yang a ming men
• Posiluje plicní yin
• Vyživuje esenci ledvin
• Transformuje hlen a zastavuje kašel
• Uklidňuje ducha
• Podporuje obrannou qi [1]

Upozornění

• Nepodávat večer!
• Ne u stavů nespavosti, horkých onemocněních, uakutních zánětů, při všech stavech horkosti.
• Opatrně v těhotenství. [1]

Účinné látky

• Polysaccharide components
• Cordycepin
• Isolated from C. militaris [2]

Zdroj informací: