MUDr. Dana Maňasková


Vyhledávání na medicinman.cz
 

potraviny/hmyz/rizika

Mealworm (Tenebrio molitor) Anaphylaxis

A case report conducted in France

  • Described a severe food anaphylaxis being induced by the mealworm (Tenebrio molitor) in a 31-year-old man
  • Allergic to HDM but not to crustaceans, who consumed one cooked larva
  • Prick-tests and a serum proteomic analysis
    • Tenebrio molitor proteins to which he was sensitized
      • Hexamerin,
      • Tropomyosin,
      • Alpha-amylase
        • Previously identified as an allergen in mealworm with a structural homology with HDM
      • Larval cuticle proteins A1A and A2B
        • Both known mealworm allergens
  • www.mdpi.com/2072-6643/15/14/3076

Chemical hazards


Direct sensitization



Immunoglobulin E (IgE) cross-reactivity

Tropomyosin and arginine kinase

  • Have been found to be responsible for cross-reactivity between insects and other arthropods
  • protein-source-">www.dvm360.com/view/the-buzz-on-insect-based-diets-a-new-hypoallergenic-protein-source-

IgE from canine sera sensitized to storage mites

  • Bound to the protein in yellow mealworm
  • IgE binding, however, does not mean that an allergic reaction will occur
  • protein-source-">www.dvm360.com/view/the-buzz-on-insect-based-diets-a-new-hypoallergenic-protein-source-

Patients with shellfish allergies

  • Allergic reactions after eating
    • Cicadas
    • Vegetable worms
  • protein-source-">www.dvm360.com/view/the-buzz-on-insect-based-diets-a-new-hypoallergenic-protein-source-

Patients allergic to shrimp

  • Double-blind placebo-controlled food challenge,
    • 87% of patients allergic to shrimp and often also to dust mites
    • Displayed allergy symptoms after eating yellow mealworm
  • protein-source-">www.dvm360.com/view/the-buzz-on-insect-based-diets-a-new-hypoallergenic-protein-source-

Atopic dermatitis

  • May affect 3% to 15% of dogs
    • Dust mites are the allergens most commonly recognized by the circulating IgE of dogs with atopic dermatitis
      • Use of insects as a protein source in dog food must be undertaken with caution.
  • protein-source-">www.dvm360.com/view/the-buzz-on-insect-based-diets-a-new-hypoallergenic-protein-source-

Postharvest processing

  • Thermal and high pressure processing
  • Hydrolysis—of allergy-causing proteins
    • Affect the allergenicity of feed
    • May reduce their allergenicity and cross-reactivity
  • protein-source-">www.dvm360.com/view/the-buzz-on-insect-based-diets-a-new-hypoallergenic-protein-source-

Microbiological risks


Prevalence of allergic reactions to insects, and even death

  • Considerably high

North-Eastern Thailand

China

  • Of all of the allergic causes for anaphylactic shock and fatalities in the collected Chinese literature, from 1980 to 2007
    • 14% were attributed to locust and grasshopper ingestion
  • www.mdpi.com/2072-6643/15/14/3076


Toxicity studies


Insect Allergenic Extracts

  • Ant, fly, cockroach, and mosquito allergenic extracts
  • Allergen Immunotherapy
  • Ant, Fly, Cockroach, Mosquito Allergenic Extracts
  • Diagnostic testing
  • Part of a treatment regime for allergic disease

Side Effects of Insect Allergenic Extracts?

  • Hives,
  • Difficulty breathing,
  • Swelling of your face, lips, tongue, or throat,
  • Generalized skin redness,
  • Itching,
  • Skin swelling,
  • Runny nose,
  • Wheezing,
  • Itching of nose and throat,
  • Shortness of breath,
  • Coughing,
  • Low blood pressure
  • Injections site reactions:
    • Redness,
    • Itching,
    • Swelling,
    • Tenderness
    • Pain
  • Serious systemic reactions include:
    • Generalized skin redness,
    • Hives,
    • Itching,
    • Skin swelling,
    • Runny nose,
    • Wheezing,
    • Throat swelling,
    • Itching of nose and throat,
    • Shortness of breath,
    • Coughing,
    • Low blood pressure (hypotension), and
    • Sweating
    • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
    • Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; and sudden dizziness, lightheadedness, or passing out;
    • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.
  • This document does not contain all possible side effects and others may occur
  • It is unknown if it would affect a fetus
  • Unknown if Ant, Fly, Cockroach, Mosquito Allergenic Extracts pass into breast milk. Consult your doctor before breastfeeding.
  • Use of allergenic extracts for therapeutic purpose
    • Established by well-controlled clinical studies
  • Allergenic extracts may be used as adjunctive therapy along with pharmacotherapy which includes
    • Antihistamines, corticosteroids, and cromoglycate, and avoidance measures.
  • Using only the allergen selection to which the patient is allergic
    • Has a history of exposure and are likely to be exposed to again.
  • Detailní návod na použití na odkazu níže:
  • www.rxlist.com/insect-allergenic-extracts-drug.htm

O úroveň výše

Poslední aktualizace: 26. 9. 2023 0:07:17