MUDr. Dana Maňasková


Vyhledávání na medicinman.cz
 

Mechanismus účinku

N-acetylcysteine (NAC) breaks disulphide bonds

  • Thiol-containing compound interfering with endogenous thiols
    • Cysteine (Cys)
    • Hcy
  • By forming with them mixed disulphides
    • Possibly more efficient renal clearance [7]
    • Excess NAC v.s. displaces thiols from their plasma binding sites forming mixed disulphides.
      • Urinary total Cys and Hcy excretion significantly increased at the end of the day of NAC infusion
        • 10x for Cys
        • 5x for Hcy [7]
      • Reduced appreciably on the following day [7]
  • Treatment with NAC and placebo was performed in a double blind study
    • Treatment effects
      • Plasma Lp(a) - no significant effect
      • Plasma amino thiols - significantly reduced during treatment with NAC
        • homocysteine - by 45%
        • Cysteine - by 11%
        • Cysteinyl glycine - by 24% [6]
    • High dose of NAC was well tolerated [6]

O úroveň výše

Poslední aktualizace: 30. 12. 2017 1:24:43