MUDr. Dana Maňasková


Vyhledávání na medicinman.cz
 

Dýchací řetězec

Dýchací řetězec - MRC

  • Mitochondrial respiratory chain (MRC)
  • Mediated electron transfer/oxidative phosphorylation

MTCH

  • Central role in the regulation of cellular survival and apoptosis [1]
  • Intracellular calcium homeostasis
  • Various ion channels and transporters [1]

Mitochondrial oxidative capacity

  • And capacity for glycolysis
  • Important component of the expression of insulin resistance [1]
    • Diabetes 2. typu jako porucha spalování a vyčerpaná kapacita střádání energie (vlastní názor na tuto nemoc)
  • Maximal oxygen uptake tended to be lower in post obese [1]
    • Markers of aerobic capacity of skeletal muscle, may be factors predisposing to obesity [1]

MTCH and biogenesis

  • C-Myc role [1]
  • ER? and c-MYC physically interact to stabilize the ER?-coactivator complex, thereby permitting other signal transduction pathways to fine-tune estrogen-mediated signaling networks. [1]

MTCH a estrogeny

  • E2 or EE stimulated MRC activity via ERs
    • Increased generation of mitochondrial superoxide
    • + ATP
    • Increased oxygen consumption
    • Inhibition of apoptosis
    • Enhanced distribution of glutasthone in nucleus and mitochondria [1]
  • Ovx-induced obesity in mice is associated
    • Decrease in oxygen consumption
    • Repressed energy expenditure in the absence of E2 [1]

C-myc

  • Key transcription factors
  • Regulation of enzymes/proteins involved in glycolysis and MRC
  • Over-expression of c-myc in liver
    • Prevented obesity and insulin resistance in mice [2]

Enzymy

  • MtDNA-encoded subunits
    • Basic catalytic role of electron transport [1]
    • MtDNA higher in female rats than in male rats [1]
  • NDNA
    • Regulatory role [1]

Complex I = NADH-ubiquinone oxidoreductase

Complex II

  • NDNA

Coenzym Q

Complex III

Complex IV

Cytochrome-c oxidase

  • Lower in subjects with NIDDM [1]

Complex V = Mitochondrial ATP synthase (complex V)



Literatura:

[1] Regulation of Energy Metabolism Pathways by Estrogens and Estrogenic Chemicals and Potential Implications in Obesity Associated with Increased Exposure to Endocrine Disruptors. URL < www.ncbi.nlm.nih.gov/pmc/articles/PMC2747085/?tool=pmcentrez >.
O úroveň výše

Poslední aktualizace: 9. 4. 2012 23:59:58