Inhibice histidin dekarboxylázy
Histidine decarboxylase
- Enzyme that catalyzes the conversion of histidine to histamine
- Block this enzyme, you can use histidine decarboxylase inhibitors.
- histidine decarboxylase is an important enzyme in the body and plays a role in various physiological processes.
- Use of histidine decarboxylase inhibitors should be carefully considered and monitored by a healthcare professional
Kaempferol
Alpha-difluoromethylhistidine (DFMO)
- Specific and irreversible inhibitor of histidine decarboxylase
- DFMO has been used in the treatment of certain cancers and parasitic infections.
Cimetidine
- This is a histamine H2 receptor antagonist that has been shown to inhibit histidine decarboxylase activity in certain cell types.
Pyridoxal phosphate (PLP)
- This is a co-factor for histidine decarboxylase, but at high concentrations, it can act as an inhibitor of the enzyme.
Luteolin
- This is a flavonoid that has been shown to inhibit histidine decarboxylase in human mast cells.
Epigallocatechin gallate (EGCG)
- This is a polyphenol found in green tea that has been reported to inhibit histidine decarboxylase activity in rat gastric mucosal cells.
Tetracycline
- This is an antibiotic that has been shown to inhibit histidine decarboxylase activity in certain bacteria
Nordihydroguaiaretic acid (NDGA)
- This is a phenolic compound found in the leaves and twigs of the creosote bush (Larrea tridentata).
- NDGA has been reported to inhibit histidine decarboxylase activity in rat gastric mucosal cells.
Bromelain
- This is an enzyme derived from pineapples that has been shown to inhibit histidine decarboxylase activity in rat peritoneal mast cells.
Silibinin
- This is a flavonolignan compound found in milk thistle (Silybum marianum).
- Silibinin has been reported to inhibit histidine decarboxylase activity in human mast cells.
Berberine
- This is an isoquinoline alkaloid found in various plants, including
- Goldenseal (Hydrastis canadensis)
- Oregon grape (Berberis aquifolium).
- Berberine has been shown to inhibit histidine decarboxylase activity in rat peritoneal mast cells.
Garcinol
- This is a polyisoprenylated benzophenone derivative found in the rind of Garcinia indica.
- Garcinol has been reported to inhibit histidine decarboxylase activity in rat peritoneal mast cells.
Ursolic acid
- This is a pentacyclic triterpenoid found in various plants, including
- Rosemary (Rosmarinus officinalis)
- Holy basil (Ocimum tenuiflorum).
- Ursolic acid has been reported to inhibit histidine decarboxylase activity in rat peritoneal mast cells.
Rutin
- This is a flavonoid found in various fruits and vegetables, including
- Buckwheat (Fagopyrum esculentum)
- Citrus fruits.
- Rutin has been shown to inhibit histidine decarboxylase activity in rat peritoneal mast cells and human mast cells.
Sodium cromoglicate
- This is a mast cell stabilizer that has been shown to inhibit histidine decarboxylase activity in human mast cells.
Ellagic acid
- This is a polyphenol found in various fruits and nuts, including
- Pomegranates (Punica granatum)
- Walnuts.
- Ellagic acid has been reported to inhibit histidine decarboxylase activity in human mast cells.
Genistein
- This is an isoflavone found in soybeans and other legumes.
- Genistein has been shown to inhibit histidine decarboxylase activity in human mast cells.
Gingerol
- This is a pungent phenolic compound found in ginger (Zingiber officinale).
- Gingerol has been reported to inhibit histidine decarboxylase activity in rat peritoneal mast cells and human mast cells.
Piceatannol
- This is a stilbene compound found in various plants, including
- Grapes
- Passion fruit.
- Piceatannol has been shown to inhibit histidine decarboxylase activity in rat peritoneal mast cells and human mast cells.
Quercetin
- This is a flavonoid found in various fruits and vegetables, including
- Onions
- Apples.
- Quercetin has been shown to inhibit histidine decarboxylase activity in rat peritoneal mast cells and human mast cells.
Alpinetin
- This is a flavonoid found in various plants, including
- Ginger
- Alpinia officinarum.
- Alpinetin has been shown to inhibit histidine decarboxylase activity in rat peritoneal mast cells and human mast cells.
Ursodeoxycholic acid (UDCA)
- This is a bile acid that has been used to treat various liver diseases.
- UDCA has been reported to inhibit histidine decarboxylase activity in human mast cells.
- Naturally found in small quantities in humans and bears
- Inhibit histidine decarboxylase activity in rat peritoneal mast cells.
Baicalein
- This is a flavone found in the roots of Scutellaria baicalensis, a traditional Chinese herb. Baicalein has been reported to inhibit histidine decarboxylase activity in rat peritoneal mast cells and human mast cells.
Resveratrol
- This is a stilbenoid found in various plants, including grapes and berries.
- Resveratrol has been shown to inhibit histidine decarboxylase activity in rat peritoneal mast cells.
Pterostilbene
- This is a stilbenoid found in various plants, including blueberries and grapes. Pterostilbene has been reported to inhibit histidine decarboxylase activity in human mast cells.
Naringin
- This is a flavonoid glycoside found in grapefruit and other citrus fruits. Naringin has been reported to inhibit histidine decarboxylase activity in rat peritoneal mast cells.
Gossypol
- This is a polyphenol found in cottonseed oil. Gossypol has been reported to inhibit histidine decarboxylase activity in human mast cells.
Flavone
- This is a flavonoid that has been shown to inhibit histidine decarboxylase activity in human mast cells.
Dexamethasone
- This is a synthetic corticosteroid that has been shown to inhibit histidine decarboxylase activity in rat peritoneal mast cells and human mast cells.
Ursolic acid
- This is a pentacyclic triterpenoid found in various plants, including rosemary (Rosmarinus officinalis) and holy basil (Ocimum tenuiflorum). Ursolic acid has been reported to inhibit histidine decarboxylase activity in rat peritoneal mast cells.
Rutin
- This is a flavonoid found in various fruits and vegetables, including buckwheat (Fagopyrum esculentum) and citrus fruits. Rutin has been shown to inhibit histidine decarboxylase activity in rat peritoneal mast cells and human mast cells.
Sodium cromoglicate
- This is a mast cell stabilizer that has been shown to inhibit histidine decarboxylase activity in human mast cells.
Ellagic acid
- This is a polyphenol found in various fruits and nuts, including pomegranates (Punica granatum) and walnuts. Ellagic acid has been reported to inhibit histidine decarboxylase activity in human mast cells.
Genistein
- This is an isoflavone found in soybeans and other legumes. Genistein has been shown to inhibit histidine decarboxylase activity in human mast cells.
Emodin
- This is an anthraquinone found in various plants, including rhubarb (Rheum spp.). Emodin has been shown to inhibit histidine decarboxylase activity in rat peritoneal mast cells.
Naringenin
- This is a flavonoid found in grapefruit and other citrus fruits. Naringenin has been reported to inhibit histidine decarboxylase activity in rat peritoneal mast cells.
Oroxylin A
- This is a flavonoid found in the roots of Scutellaria baicalensis
- Oroxylin A has been reported to inhibit histidine decarboxylase activity in rat peritoneal mast cells.
Curcumin
- This is a polyphenol found in the rhizomes of turmeric (Curcuma longa). Curcumin has been reported to inhibit histidine decarboxylase activity in rat peritoneal mast cells and human mast cells.
Hesperidin
- This is a flavonoid glycoside found in various citrus fruits, including oranges and lemons. Hesperidin has been reported to inhibit histidine decarboxylase activity in rat peritoneal mast cells.
Isorhamnetin
- This is a flavonoid found in various plants, including onions and green tea. Isorhamnetin has been reported to inhibit histidine decarboxylase activity in rat peritoneal mast cells and human mast cells.
Nobiletin
- This is a citrus flavonoid found in various citrus fruits, including tangerines and oranges. Nobiletin has been shown to inhibit histidine decarboxylase activity in rat peritoneal mast cells and human mast cells.
Osthole
- This is a coumarin found in various plants, including Cnidium monnieri. Osthole has been reported to inhibit histidine decarboxylase activity in rat peritoneal mast cells.
Piceatannol
- This is a stilbenoid found in various plants, including grapes and passionfruit. Piceatannol has been shown to inhibit histidine decarboxylase activity in human mast cells.
Scopoletin
- This is a coumarin found in various plants, including Angelica archangelica. Scopoletin has been reported to inhibit histidine decarboxylase activity in rat peritoneal mast cells.
Silymarin
- This is a mixture of flavonolignans extracted from milk thistle (Silybum marianum). Silymarin has been shown to inhibit histidine decarboxylase activity in rat peritoneal mast cells.
Tangeretin
- This is a flavonoid found in various citrus fruits, including tangerines and oranges. Tangeretin has been reported to inhibit histidine decarboxylase activity in rat peritoneal mast cells.
Xanthohumol
- This is a prenylated chalcone found in hops (Humulus lupulus). Xanthohumol has been reported to inhibit histidine decarboxylase activity in human mast cells.
18?-Glycyrrhetinic acid
- This is a triterpenoid found in licorice root (Glycyrrhiza glabra). 18?-Glycyrrhetinic acid has been reported to inhibit histidine decarboxylase activity in rat peritoneal mast cells and human mast cells.
Berberine
- This is an isoquinoline alkaloid found in various plants, including goldenseal (Hydrastis canadensis). Berberine has been shown to inhibit histidine decarboxylase activity in rat peritoneal mast cells.
Fisetin
- This is a flavonoid found in various plants, including strawberries and cucumbers. Fisetin has been reported to inhibit histidine decarboxylase activity in rat peritoneal mast cells.
Genistein
- This is an isoflavone found in various plants, including soybeans. Genistein has been shown to inhibit histidine decarboxylase activity in rat peritoneal mast cells and human mast cells.
Myricetin
- This is a flavonoid found in various plants, including red wine and berries. Myricetin has been reported to inhibit histidine decarboxylase activity in rat peritoneal mast cells.
Oleanolic acid
- This is a triterpenoid found in various plants, including olive leaves and garlic. Oleanolic acid has been shown to inhibit histidine decarboxylase activity in rat peritoneal mast cells.
S-Adenosylmethionine (SAM)
- Naturally occurring molecule found in all living cells.
- SAM has been reported to inhibit histidine decarboxylase activity in rat peritoneal mast cells and human mast cells.
