Omega 6 mastné kyseliny

AA

• Precursor of pro-inflammatory eicosanoids
• Active in very small quantities
• Contribute to the formation of
• Thrombosis,
• Atheromatosis,
• Allergic
• Inflammatory disorders
• If they are formed in large amounts

• Benatti et al. 2004

• digital.library.adelaide.edu.au/dspace/bitstream/2440/86232/8/02whole.pdf

Concept of replacing dietary saturated fat with omega-6 linoleic acid (LA)

• LA is found in high concentrations in
• Safflower oil,
• Sunflower oil,
• Cottonseed oil,
• Corn oil,
• Soybean oil.
• Initially recommended as replacements for saturated fat in the diet, the findings of the Sydney Diet Heart Study suggests this may be a mistake

Sydney Diet Heart Study

• Randomized controlled trial in 458 men
• Conducted between 1966 to 1973
• Intervention group received replacement of dietary fat with omega-6 linoleic acid in the form of safflower oil and polyunsaturated margarine
• Had higher rates of death than controls (17.6 % versus 11.8 %, hazard ratio 1.62)
• Suggesting that substituting dietary linoleic acid in place of saturated fats
• Actually increased the rates of death from all causes, CHD, and CVD
• Deleterious effects from LA included in omega-3 supplements
• May substantially attenuate a benefit from omega-3 supplementation.
• link.springer.com/article/10.1007/s12170-014-0407-4