nemoci-sympt/ONKOLOGIE/glioblastom/zlepsujici-podpurne-vlivy

LDH-A inhibitory

• Zejména u melanomu a glioblastomu

Mebendazole

• Inhibits colony formation, reduces angiogenesis, and induces cytotoxicity in meningioma cells via caspase-3 activation. The anti-tumor effects of Mebendazole are enhanced by radiation [282]. In medulla blastoma, Mebendazole suppresses the primary cilium formation, a tubulin-based organelle that is a signaling hub for the Hedgehog pathway leading thus to reduced cell growth

Arsenic Trioxide (ATO) -arsenic

• Ancient mineral Chinese Herb
• Strong toxicity
• Treatment of promyelocytic leukemia
• Arsenide has shown a unique therapeutic effect on lung cancer, pancreatic cancer, glioblastoma, liver cancer and other cancers
• ATO can inhibit the proliferation of lung cancer CSC
• Reduce its colony formation ability
• By reducing the expression of Gli1 and its downstream genes such as N-myc and GAS1
• Inhibit the activity of pancreatic cancer CSC in vitro and in vivo
• By binding to SHH-Gli protein
• In glioblastoma, ATO down-regulates the Notch pathway
• To reduce the proliferation and recurrence of glioblastoma
• Low ATO concentration leads to the morphological differentiation of glioblastoma stem cell-like cells
• ATO and parthenolide synergistically
• Inhibit the proliferation and induce apoptosis of hepatoma HepG2 cells,
• Effectively inhibit hepatoma stem cells
• Block the cell cycle by down-regulating the expression of sorting positive cells
• Thereby inhibiting cell proliferation and promoting cell apoptosis and necrosis to exert anti-tumor effect
• www.oatext.com/chinese-herb-in-the-treatment-and-regulation-of-cancer-stem-cells.php

G. mangostana xanthones

• Xanthones other than a-mangostin. Gartanin, b-mangostin, and a-mangostin
• The next most abundant xanthones
• Significant anticancer activity
• In some cases, even more potent than that of a-mangostin

3 malignant glioma cell lines

• Gartanin appeared to the most potent of the 7 and significantly affected cell viability at 10 uM in T98G, U87, and U251 glioma cells
• Gartanin did not appear to be cytotoxic in T98G cells, but decreased colony formation, caused G0/G1 cell cycle arrest, decreased migration
• www.sciencedirect.com/science/article/abs/pii/S1043661821006162

Alpha-mangostin

• The AMPK pathway was also activated in glioblastoma cell lines GBM8401 and DBTRG-05MG with reported IC50 values of alpha-mangostin that included 6.4 and 7.3 µM, respectively
• While apoptosis was not induced in these cells, autophagy was induced and an increase in phosphorylated AMPK but not in the levels of PI3K, AKT, PTEN, or ERK was observed.
• AMPK was hypothesized to be the main driver of autophagy in a-mangostin-treated-cells
• www.sciencedirect.com/science/article/abs/pii/S1043661821006162

Melatonin has a scientific name of N-acetyl-5- methoxytryptamine

• For cancer of the breast, brain, lung, prostate, head, neck, and gastrointes?tinal tract
• Melatonin is also used for jet lag, insomnia, nicotine withdrawal, headache, hypertension, and other conditions.
• Can decrease the incidence of cytokine-induced hypotension for patients with cancer.
• Interleukin-2 and tumor necrosis factor
• Examples of cyto?kines (Lissoni et al., 1996a)
• Quick-release melatonin
• May be beneficial in decreasing potential sleep disorders associated with conditions such as
• Thrombocytopenia induced by chemotherapy or interleukin-2 (Bregani et al., 1995; Micromedex Healthcare Series, 2003; Lissoni et al., 1995, 1996b, 1999).
• Beneficial in stabilizing disease for adults with solid tumors who do not respond to treatments or cannot receive treatments (Micromedex Healthcare Series; Lissoni et al., 1991, 1994a).

Herbs or Natural Products That Decrease Cancer Growth Part One of a Four-Part Series; Muriel J. Montbriand, PhD, RN; Downloaded on 08 28 2019. Single-user license only. Copyright 2019 by the Oncology Nursing Society. For permission to post online, reprint, adapt, or reuse, please email pubpermissions@ons.org

Melatonin + interleukin-2

• Seems to improve survival for pa?tients with advanced solid tumors of the breast, gastrointesti?nal tract, kidney, liver, and lung and melanoma (

Melatonin + triptorelin pamoate

• For prostate cancer, radiotherapy for glioblastoma

Micromedex

• melatonin + interferon for renal cell cancer (Micromedex Healthcare Series).

Adverse effects of melatonin

• Headaches, transient depression,
• Daytime fatigue and drowsiness,
• Dizziness, abdominal cramps,
• Irritability (Micromedex Healthcare Series, 2003; Wagner, Wagner, & Hening, 1998)
• Reduces alertness (Dollins et al., 1993, Micromedex Health?care Series)
• Commercially available melatonin usually is synthesized in laboratories
• Possible contamination
• Optimal safe dose has not been established
• 20-50 mg along with radiation or chemotherapy has been used for cancer treatment (Brzezinski, 1997; Micromedex Healthcare Series, 2003).

Herbs or Natural Products That Decrease Cancer Growth Part One of a Four-Part Series; Muriel J. Montbriand, PhD, RN; Downloaded on 08 28 2019. Single-user license only. Copyright 2019 by the Oncology Nursing Society. For permission to post online, reprint, adapt, or reuse, please email pubpermissions@ons.org