MUDr. Dana Maňasková


Vyhledávání na medicinman.cz
 

nemoci-sympt/ONKOLOGIE/melanom/zhorusujici-vyvolavajici-rizikove-faktory

Inosine


Strava


Syntenin


HML2 Env oncogenicity

  • HML2-derived Env and Rec proteins
    • Detected at variable percentages in melanoma biopsies and cell lines
    • Generally absent in normal melanocytes (Muster et al., 2003; Büscher et al., 2005, 2006)
  • HML2 virus-like particles with RT activity but lacking infectivity were observed in melanoma cell cultures (Muster et al., 2003; Büscher et al., 2005, 2006; Serafino et al., 2009)
  • HML2 Env was shown to trigger humoral immunity in ~20% of melanoma patients
    • Patients with anti-HML2 Abs had a decreased overall survival (Büscher et al., 2005; Hahn et al., 2008)

HML2 Env inhibition

  • Decreased the fusion of cultured melanoma cells
    • V.s. role in the formation of multinuclear cancer cells and in the onset of genetic heterogeneity conferring trophic and survival advantages to tumor cells (Huang et al., 2013a)
  • Pivotal role in melanoma development has been suggested for cancer subpopulations bearing stem cell properties (Frank et al., 2010).
  • CD133+ melanoma cell lines undergoing medium-induced phenotype-switching showed stemness features (enhanced proliferation, migration and invasion) concomitant with the activation of HML2 expression
    • V.s. role in cellular plasticity (Argaw-Denboba et al., 2017)
  • Stress conditions stimulating the transition from an adherent to a non-adherent (and more malignant) phenotype
    • Led to a concomitant upregulation of HML2 expression
  • HML2 expression inhibition was in turn able to prevent the phenotype-switch (Serafino et al., 2009)
  • HML2 Env expression has been related to ERK activation
    • Being downregulated after the inhibition of MEK or CDK4 (Li et al., 2010)
  • Augmented HML2 expression in melanoma
    • Could represent a tumor epiphenomenon
      • Especially in the presence of impairments in cellular signaling and stress conditions
  • UV irradiation is a known risk factor
    • Trigger HERV-K protein expression (Reiche et al., 2010; Schanab et al., 2011)
  • Melanoma-specific transcription factor
    • Activate HML2 LTRs (Katoh et al., 2011) and the RB protein
      • Downstream mediator of BRAF–MEK–ERK signaling often altered in cancers
        • Key regulator of DNA methylation that can influence HERV expression (Li et al., 2010).
  • www.frontiersin.org/articles/10.3389/fmicb.2018.00462/full

Hypofunkce štítnice


Ketolátka acetoacetát

  • V600E mutation rewires cancer cells' metabolism, stimulating the ketogenesis pathway.
    • Ketogenesis, the body breaks down fats for energy when glucose levels in the blood are low.
    • One of the alternative energy sources produced by ketogenesis is acetoacetate.
  • Within cancer cells with the V600E mutation,
    • Acetoacetate production is stimulated
    • Acetoacetate binds the mutated B-raf protein
      • Promotes its oncogenic activity, forming a cycle of positive feedback.
  • A ketogenic diet with very low carbohydrates, like an Atkins diet,
    • Can cause acetoacetate levels in the body to rise.
  • Fasting can also trigger the same effect
  • www.sciencedaily.com/releases/2017/01/170112141359.htm
  • = nehladovět !!
  • Měření ketolátek v moči - a nenacházet je zvýšené !!!

Kyselina listová

  • Nebrat v žádném doplňku

Tuky a ketodieta bohatá na tuky při generalizaci

  • Research in mice suggests that cancers with BRAF V600E will grow faster in response to a high-fat 'ketogenic' diet.
  • In addition, lipid-lowering agents such as statins curb these cancers' growth, even in the context of a more normal diet.
  • www.sciencedaily.com/releases/2017/01/170112141359.htm

Vitamín B12

  • Potraviny nejbohatší na vitamín B12...
O úroveň výše

Poslední aktualizace: 10. 12. 2023 21:19:50