nemoci-sympt/ONKOLOGIE/nadory-jater-karcinom/zlepseni
Varování
- The majority of studies cited are in vitro studies, performed in glass on tissue from a living organism, or in vivo studies, performed on tissue not removed from a living organism (animal studies).
- Most studies have not advanced to clinical trials on humans.
- The few human studies cited are preliminary clinical trials.
- Therefore, although results seem favorable or unfavorable, treat them with caution.
- Neither the author nor publisher makes any medical claims for any of the herbs or natural products in this review or the tables.
- This are just study notes
- Note that some of the herbs described are deadly poisons and extremely dangerous.
ADI-PEG20
- Terapie deprivací argininu;
- Melanom, rakovina jater
IP-6 has- Inositol hexaphosphate
- Self-medicate with IP-6 to prevent cancer, increase white blood cells, prevent heart attacks, treat kidney stones,
- Enhance the immune system (Natural Medicines Compre?hensive Database, 2004)
- IP-6 has demonstrated anticancer activities in
- breast, colon, liver, and prostate cancers, as experimental tumors (Challa, Rao, & Reddy, 1997; Saied & Shamsuddin, 1998; Shamsuddin & Vucenik, 1999; Shamsuddin & Yang, 1995; Thompson & Zhang, 1991; Vucenik, Zhang, & Shamsuddin, 1998).
- No adverse reactions have been noted.
- Dose of 500 mg-2 g twice daily has been used to prevent cancer
- 5-8 g daily to treat existing cancer;
- These are not recommended or typical doses (Natural Medicines Comprehensive Database)
Herbs or Natural Products That Decrease Cancer Growth Part One of a Four-Part Series; Muriel J. Montbriand, PhD, RN; Downloaded on 08 28 2019. Single-user license only. Copyright 2019 by the Oncology Nursing Society. For permission to post online, reprint, adapt, or reuse, please email pubpermissions@ons.org
Butyrate
- Short-chain fatty acid produced by the gut microbiota during the fermentation of dietary fibers,
- Inhibit HDACs class III
- Affects post-translational modifications of histones (Delage and Dashwood, 2008; Morrison and Preston, 2016).
- Butyrate has been shown to reduce the growth of
- Hepatocellular carcinoma (Wang et al., 2013; Pant et al., 2017b),
- Lung cancer (Amoedo et al., 2011),
- Breast cancer (Chopin et al., 2004),
- Pancreatic cancer (Farrow et al., 2003; Natoni et al., 2005),
- Colon cancer cells
- By increasing histone acetylation (Donohoe et al., 2012, 2014).
- www.frontiersin.org/articles/10.3389/fchem.2022.948217/full
Canagliflozin
- Ten weeks after administration of canagliflozin in a patient with cirrhosis and diabetes, a spontaneous regression of HCC was reported, which was linked, in this patient, to a significant downregulation of some angiogenesis-related cytokines [153]. Under the influence of canagliflozin, downregulation of matrix metalloproteinase-8 (MMP-8), angioprotein-1, angioprotein-2, prolactin and placenta growth factor-AA (PGF-AA) occurred. Spontaneous tumour regression is a rare and poorly understood phenomenon and the described case may indicate that SGLT-2 inhibitors can cause HCC regression by inhibiting angiogenesis
- www.ncbi.nlm.nih.gov/pmc/articles/PMC9738342/
Celastrus orbiculatus
- Genus Cornelius
- Anti-tumor, anti-inflammation, anti-virus and anti-oxidation activities
- Extract can inhibit the invasion and metastasis of stem-like cells of esophageal squamous cell carcinoma
- Regulate the generation of mitochondria mediated by DJ-1
- Reverse the epithelial mesenchymal transformation of liver cancer cells
- May be related to the mTOR signaling pathway
- www.oatext.com/chinese-herb-in-the-treatment-and-regulation-of-cancer-stem-cells.php
Fisetin (3',4',7-trihydroxyflavonol)
- Naturally occurring flavonoid
- Abundant in several fruits and vegetables, including strawberry, apple, persimmon, grape, onion and cucumber
- Multiple biological activities including anti-proliferative, pro-apoptotic, neuroprotective and anti-oxidative activities
- Suppress the proliferation of a wide variety of tumor cell, including
- Prostate cancer
- Liver cancer
- Colon cancer
- Leukemia cells
- Inhibit
- Mitogen-activated protein kinase (MAPK)
- Nuclear factor (NF)-kappaB signaling pathways in various type of cancer cell
- Colon and pancreatic cancer
- Reduce the invasive and migratory capacity of the A549 human lung cancer cell line
- Via the extracellular signal-regulated kinase (ERK) signaling pathway
- www.ncbi.nlm.nih.gov/pmc/articles/PMC5792763/
Alpha-mangostin
The IC50s of ?-mangostin in SK-HEP-1 hepatocarcinoma cells were reported to be 24.8 and 19.6 µM at 24 and 48 h, respectively, and further evaluation determined that ?-mangostin inhibited the p38 MAPK pathway and promoted mitochondrial apoptosis [31]. A study using sorafenib-resistant HepG2 hepatocarcinoma cells evaluated the effect of ?-mangostin on the TGF-ß/Smad pathways, which have been shown to be inversely related to the PI3K/AKT pathways, and found that there was an increase in the activation of these pathways [32], [33]. At 23.74 µM, ?-mangostin reduced the cell viability of sorafenib-resistant HepG2 cells and combination treatments of 10 µM sorafenib (i.e. a RAF/MEK/ERK, VEGFR, and PDGFR inhibitor) and 10 µM ?-mangostin induced partial epithelial to mesenchymal transition, instead of a complete transition, and upregulated TGF-ß/Smad pathway signaling and expressionMelatonin has a scientific name of N-acetyl-5- methoxytryptamine
- For cancer of the breast, brain, lung, prostate, head, neck, and gastrointes?tinal tract
- Melatonin is also used for jet lag, insomnia, nicotine withdrawal, headache, hypertension, and other conditions.
- Can decrease the incidence of cytokine-induced hypotension for patients with cancer.
- Interleukin-2 and tumor necrosis factor
- Examples of cyto?kines (Lissoni et al., 1996a)
- Quick-release melatonin
- May be beneficial in decreasing potential sleep disorders associated with conditions such as
- Thrombocytopenia induced by chemotherapy or interleukin-2 (Bregani et al., 1995; Micromedex Healthcare Series, 2003; Lissoni et al., 1995, 1996b, 1999).
- Beneficial in stabilizing disease for adults with solid tumors who do not respond to treatments or cannot receive treatments (Micromedex Healthcare Series; Lissoni et al., 1991, 1994a).
Herbs or Natural Products That Decrease Cancer Growth Part One of a Four-Part Series; Muriel J. Montbriand, PhD, RN; Downloaded on 08 28 2019. Single-user license only. Copyright 2019 by the Oncology Nursing Society. For permission to post online, reprint, adapt, or reuse, please email pubpermissions@ons.org
Melatonin + interleukin-2
- Seems to improve survival for patients with advanced solid tumors of the breast, gastrointestinal tract, kidney, liver, and lung and melanoma
Melatonin + triptorelin pamoate
- For prostate cancer, radiotherapy for glioblastoma
Micromedex
- melatonin + interferon for renal cell cancer (Micromedex Healthcare Series).
Adverse effects of melatonin
- Headaches, transient depression,
- Daytime fatigue and drowsiness,
- Dizziness, abdominal cramps,
- Irritability (Micromedex Healthcare Series, 2003; Wagner, Wagner, & Hening, 1998)
- Reduces alertness (Dollins et al., 1993, Micromedex Healthcare Series)
- Commercially available melatonin usually is synthesized in laboratories
- Possible contamination
- Optimal safe dose has not been established
- 20-50 mg along with radiation or chemotherapy has been used for cancer treatment (Brzezinski, 1997; Micromedex Healthcare Series, 2003).
Herbs or Natural Products That Decrease Cancer Growth Part One of a Four-Part Series; Muriel J. Montbriand, PhD, RN; Downloaded on 08 28 2019. Single-user license only. Copyright 2019 by the Oncology Nursing Society. For permission to post online, reprint, adapt, or reuse, please email pubpermissions@ons.org
Pien Tze Huang from the Ming Dynasty
Bezoar, panax notoginseng, snake gall, musk and other drugs
- Reduce the number of stem cells in HT-29 and SW620 colorectal cancer cell lines
- Inhibit the proliferation of colorectal cancer cells in these two cell lines
- Reduce the viability and spheroid formation ability of HT-29 SP cells
- Inhibit the growth and tumorigenicity of hepatocellular carcinoma stem cells
- www.oatext.com/chinese-herb-in-the-treatment-and-regulation-of-cancer-stem-cells.php
Rosemary extracts
- Active compounds carnosic acid
- Rosmarinic acid
- Inhibit the proliferation of various human cancer cell lines, including
- NCI-H82 (human, small cell lung carcinoma)
- DU145 (human prostate carcinoma)
- Hep-3B (human [black] liver carcinoma)
- K-562 (human chronic myeloid leukemia)
- MCF-7 (human breast adenocarcinoma)
- PC-3 (human prostate adenocarcinoma)
- MDA-MB-231 (human breast adenocarcinoma; Yesil-Celiktas et al. 2010)
- Decrease in TNF-?-induced ROS generation and NF-?B activation
- Enhanced TNF-?-induced apoptosis (Moon et al. 2010)
- Carnosol
- Was the most effective in reducing tumor proliferation
- Induce apoptotic cell death in high-risk pre-B acute lymphoblastic leukemia (ALL; Dorrie, Sapala, and Zunino 2001)
- Decrease in Bcl-2
- Decreased the percentage of cell death in the pre-B ALL lines SEM, RS4;11, and REH when combined with cytarabine, methotrexate, or vincristine
- Compared to these chemotherapeutic agents alone
- Carnosol, and possibly other constituents in rosemary, may block the terminal apoptotic events induced by some chemotherapeutic drugs and therefore may decrease the effectiveness of some standard therapies for leukemia [18]
- www.ncbi.nlm.nih.gov/books/NBK92774/
A number of epidemiological studies (published in Chinese) conducted in an area of southeast China that is endemic for hepatocellular carcinoma have been summarized by IARC (2010). Overall, a positive association was found between the risk for hepatocellular carcinoma and water source from surface waters, with estimates of relative risk ranging from 1.5 to 4. Consumption of pond or ditch water was associated with an 8-fold increase in liver cancer incidence when compared with well water consumption. Microcystin-producing cyanobacteria are abundant in surface waters in this area, with significant amounts of microcystins detected in pond and ditch waters, whereas no detectable levels were found in deep well water; this suggests that microcystins in drinking water may have been partially responsible for the higher incidence of hepatocellular carcinomas.
Ubenimex
Suppresses glycolysis mediated by CD13/Hedgehog signaling to enhance the effect of cisplatin in liver cancer
- Ubenimex suppressed the expression levels of glycolysis-related proteins
- By decreasing the expression levels of cluster of differentiation 13 (CD13)
- While overexpression of CD13 could restore the activity of glycolysis.
- The glycolysis inhibitor 2-deoxy-D-glucose
- Enhanced the antiproliferative effect of ubenimex and CDDP
- Inhibition of the activity levels of the Hedgehog (Hh) pathway members
- Was accompanied by a decrease in CD13 expression,
- Which was reversed following CD13 overexpression.
- Moreover, ubenimex inhibited the production of lactic acid and adenosine triphosphate (ATP)
- As well as the expression of key proteins involved in glycolysis,
- Which was similar to the effects caused by the Hh inhibitor cyclopamine
- Effects of ubenimex were mediated by targeting CD13,
- While cyclopamine exhibited no effects on CD13,
- Hh signaling occurred in the downstream of CD13
- The inhibition of glycolysis by cyclopamine was reduced following CD13 overexpression
- Which further indicated that ubenimex targeted the CD13/Hh pathway to inhibit glycolysis.
- Finally, wound healing and transwell assays and cell proliferation and apoptosis analysis
- Demonstrated that ubenimex inhibited glycolysis by alleviating the CD13/Hh pathway,
- Which in turn enhanced the effects of CDDP on inhibiting the progression of liver cancer.
- Ubenimex inhibits glycolysis by targeting the CD13/Hh pathway, thus playing an anti-tumor role together with CDDP. This study demonstrated the adjuvant effect of ubenimex from the perspective of Hh signal-dependent glycolysis regulation.
- https://tcr.amegroups.org/article/view/79165/html
Jaterní denervace - jaterní vagotomie (HV)
- Významně snížila zátěž jaterních nádorů,
- Zlepšila vagotomie únavu související s rakovinou a chování podobné úzkosti
- Transplantace mikrobioty od dárců HCC byla dostatečná ke zhoršení chování
- Nádor, spíše než vagotomie, výrazně změnil fekální bakteriální složení
- Zvýšil Desulfovibrionales a klostridiální taxony
- U myší bez nádoru vagotomie umožnila mikrobiotě spojené s HCC aktivovat jaterní CD8+ T buňky.
- Střevní bakterie ovlivňují chování a protinádorovou imunitu jater
- Prostřednictvím dynamické a farmaceuticky zaměřitelné osy vagus-játra.
