nemoci-sympt/ONKOLOGIE/nadory-kolorekta/zlepseni
Varování
- The majority of studies cited are in vitro studies, performed in glass on tissue from a living organism, or in vivo studies, performed on tissue not removed from a living organism (animal studies).
- Most studies have not advanced to clinical trials on humans.
- The few human studies cited are preliminary clinical trials.
- Therefore, although results seem favorable or unfavorable, treat them with caution.
- Neither the author nor publisher makes any medical claims for any of the herbs or natural products in this review or the tables.
- This are just study notes
- Note that some of the herbs described are deadly poisons and extremely dangerous.
6-gingerol
- Was reported to inhibit cell proliferation of human colon cancer SW-480 cells and HCT116 cells and induced apoptosis in SW-480 cells, associated with activation of caspases 8, 9, 3, and 7 and cleavage of poly ADP ribose polymerase (PARP) (Radhakrishnan et al., 2014).
- www.sciencedirect.com/topics/neuroscience/shogaol
Beta-Sitosterol
- A plant fat and phytosterol known as beta-sito-sterol
- Several European prostate drugs
- Block the growth of prostate cancer cells
- Study on an androgen-dependent line of prostate cancer cells
- Beta-sitosterol decreased cancer cell growth by 24%
- Increased apoptosis four-fold
- 50% increase in production of ceramide
- An important cell membrane component believed to induce apopotosis [19]
- Androgen-dependent line of human prostate cancer cells (PC-3 cell line) implanted in mice
- 2% mixture of beta-sitosterol
- Beta-sitosterol, as well as another phytosterol known as campesterol
- Inhibited growth of the prostate cancer cells by 70% and 14%
- Inhibited the invasion of the prostate cancer cells into Matrigel-coated membranes by 78% compared to controls
- Tumor motility—was reduced by 60-93%
- Adhesiveness and ability to form tumor clumps - reduced the binding of these cancer cells to laminin by 15-38% and to fibronectin by 23%
- 2% mixture of cholesterol on these cells
- Increased cell growth by 18% [19]
- Increased invasiveness by 43%
- Tumor mobility increased by 67% when in the cholesterol
- Increased cell-binding to type IV collagen by 36% [19]
- Phytosterols inhibited the growth and metastasis of these (PC-3) prostate cancer cells
- Beta-sitosterol - much more effective than campesterol in most parameters assessed [19]
- Beta-sito-sterol may induce the inhibition of tumor growth
- By stimulating apoptosis
- Arresting cells at different locations in the cell cycle
- May involve alterations in reactive oxygen species
- Production of prostaglandin
- Suggested phytosterol dosage is 169 milligrams twice daily with or without food [19]
- Activates the sphingomyelin cycle and induces apoptosis in LNCaP human prostate cancer cells
- ß-sitosterol suppressed prostate cancer cell proliferation, migration and invasion, but had no or minor effects on adhesion [27]
- Beta-sitosterol (BS)
- Anticancer properties against
- Breast cancer,
- Prostate cancer,
- Colon cancer,
- Lung cancer,
- Stomach cancer,
- Ovarian cancer
- Leukemia
- BS interfere with multiple cell signaling pathways, including
- Cell cycle, apoptosis, proliferation, survival, invasion, angiogenesis, metastasis and inflammation
www.tandfonline.com/doi/abs/10.1080/01635581.2015.1087042?scroll=top&needAccess=true&journalCode=hnuc20
IP-6 has- Inositol hexaphosphate
- Self-medicate with IP-6 to prevent cancer, increase white blood cells, prevent heart attacks, treat kidney stones,
- Enhance the immune system (Natural Medicines Compre?hensive Database, 2004)
- IP-6 has demonstrated anticancer activities in
- breast, colon, liver, and prostate cancers, as experimental tumors (Challa, Rao, & Reddy, 1997; Saied & Shamsuddin, 1998; Shamsuddin & Vucenik, 1999; Shamsuddin & Yang, 1995; Thompson & Zhang, 1991; Vucenik, Zhang, & Shamsuddin, 1998).
- No adverse reactions have been noted.
- Dose of 500 mg-2 g twice daily has been used to prevent cancer
- 5-8 g daily to treat existing cancer;
- These are not recommended or typical doses (Natural Medicines Comprehensive Database)
Herbs or Natural Products That Decrease Cancer Growth Part One of a Four-Part Series; Muriel J. Montbriand, PhD, RN; Downloaded on 08 28 2019. Single-user license only. Copyright 2019 by the Oncology Nursing Society. For permission to post online, reprint, adapt, or reuse, please email pubpermissions@ons.org
Kurkumin
Several combination trials currently ongoing
- In combination with neoadjuvant capecitabine and radiation in rectal cancer (NCT00745134)
- With FOLFOX in inoperable colon cancer (NCT01490996)
- curcumin monotherapy in advanced pancreatic cancer (NCT00094445)
- curcumin can exert anticancer properties via multiple targets
Synergism
- 1–10 µM curcumin and
- 5-fluorouracil (5-FU)
- Paclitaxel in PC-3 cells has been observed [24]
- Potentiate the cytotoxicity of chemotherapy agents in other cell lines [24]
- Curcumin-mediated MDM2 downregulation
- Sensitized the PC3 prostate cancer cell line to both
- Gemcitabine
- Radiation in cell line and mouse xenograft models [24]
[24] Complementary and Alternative Medicines in Prostate Cancer: From Bench to Bedside? Samuel J. Klempner and; Glenn Bubley; Division of Hematology and Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA; Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA. Telephone: 617-667-9296; Fax: 617-667-4809; e-mail: sklempne{at}bidmc.harvard.edu; Received March 1, 2012.; Accepted May 1, 2012.; First published online in THE ONCOLOGIST Express on May 22, 2012.
CUMIN - Cuminum cyminum
- Flowering plant in the family Apiaceae
- Thymoquinone (TQ) is the most abundant component of black cumin seed oil
- Suppress tumor cell proliferation, including
- Colorectal carcinoma,
- Breast adenocarcinoma,
- Osteosarcoma,
- Ovarian carcinoma,
- Myeloblastic leukemia,
- Pancreatic carcinoma (Gali-Muhtasib, Roessner, and Schneider-Stock 2006)
- Normal cells appear to be slightly resistant to TQ (Worthen, Ghosheh, and Crooks 1998)
- Downregulation in Bcl-xL, cyclin D1, and VEGF (Aggarwal et al. 2008)
- Induce free radical formation in tumor cells
- Effective in inhibiting human umbilical vein EC migration, invasion, and tube formation
- Role in angiogenesis (Yi et al. 2008)
- TQ (6 mg/kg/day) was also found to prevent tumor angiogenesis in a xenograft human prostate cancer (PC-3) model (Yi et al. 2008) [18]
www.ncbi.nlm.nih.gov/books/NBK92774/
Butyrate
- Short-chain fatty acid produced by the gut microbiota during the fermentation of dietary fibers,
- Inhibit HDACs class III
- Affects post-translational modifications of histones (Delage and Dashwood, 2008; Morrison and Preston, 2016).
- Butyrate has been shown to reduce the growth of
- Hepatocellular carcinoma (Wang et al., 2013; Pant et al., 2017b),
- Lung cancer (Amoedo et al., 2011),
- Breast cancer (Chopin et al., 2004),
- Pancreatic cancer (Farrow et al., 2003; Natoni et al., 2005),
- Colon cancer cells
- By increasing histone acetylation (Donohoe et al., 2012, 2014).
- www.frontiersin.org/articles/10.3389/fchem.2022.948217/full
Česnek - Allium sativum
- Vykazuje určitý inhibiční potenciál [15]
- Family Alliaceae
- Sulfur-containing constituents
- Can lower the incidence of
- Breast,
- Colon,
- Skin,
- Uterine,
- Esophagus,
- Lung cancers
- Ingesting 5 g/day of garlic
- DATS was effective in decreasing prostate cancer multiplicity in the transgenic adenocarcinoma of the mouse prostate model [18]
Cystathionine beta-synthase (CBS), one of the critical enzymes involved in the formation of H2S, is highly expressed in colorectal cancer cells in comparison with nearby adjacent normal mucosal margin cells
Fisetin (3',4',7-trihydroxyflavonol)
- Naturally occurring flavonoid
- Abundant in several fruits and vegetables, including strawberry, apple, persimmon, grape, onion and cucumber
- Multiple biological activities including anti-proliferative, pro-apoptotic, neuroprotective and anti-oxidative activities
- Suppress the proliferation of a wide variety of tumor cell, including
- Prostate cancer
- Liver cancer
- Colon cancer
- Leukemia cells
- Inhibit
- Mitogen-activated protein kinase (MAPK)
- Nuclear factor (NF)-kappaB signaling pathways in various type of cancer cell
- Colon and pancreatic cancer
- Reduce the invasive and migratory capacity of the A549 human lung cancer cell line
- Via the extracellular signal-regulated kinase (ERK) signaling pathway
- www.ncbi.nlm.nih.gov/pmc/articles/PMC5792763/
Irbesartan
Metastatic Colorectal Cancer Complete Remissions with Irbesartan - A case report
by MDs and scientists at British Columbia Cancer Agency, Canada’s Michael Smith Genome Sciences Centre, Vancouver; Department of Medical Genetics, University of British Columbia, Vancouver; Department of Pathology and Laboratory Medicine, Vancouver General Hospital, Vancouver; Division of Medical Oncology, British Columbia Cancer Agency, Vancouver; Department of Molecular Biology and Biochemistry, Simon Fraser University, Vancouver, Canada
- Response to angiotensin blockade with Irbesartan in a patient with metastatic colorectal cancer
- A 67-year-old female, not tolerating adjuvant chemotherapy
- Constant recurrence of a colorectal cancer stage 4.
- Genomic analysis and prior literature in colorectal cancers indicated that angiotensin blockade may inhibit a part of colorectal cancers.
- Patient had a pretreatment baseline PET/CT scan and started Irbesartan at a dose of 150 mg daily.
- She had a follow-up PET/CT at 5 weeks and again at 3 months (Figure B to E).
- Before the therapy, her CEA was elevated at 18 (upper limit of normal 5)
- After 5 weeks of therapy, this value decreased to a CEA of 3.1.
- Furthermore, there was virtually a complete functional radiological resolution of her disease
- Results are maintained at the 10-month point with CEA at 1.4.
- Irbesartan, is a medication used to treat
- High blood pressure,
- Heart failure,
- Diabetic kidney disease
- www.ncbi.nlm.nih.gov/pmc/articles/PMC4843189/
Kazuistika maminky paní od Zinzino
- www.youtube.com/watch?v=WwypoufeuF8
- čaj z lístků gravioly - nádor se zmenšil
- Další regrese nádoru nastala po zařazení BalanceOilu a Zinogene produktů
- metabalance.cz/?p=vyzivove-poradenstvi/balance-oil
Alpha-mangostin
- Multiple xanthones decreased the viability of DLD-1 colon cancer cells, though ?-mangostin was the most potent with an IC50 of 7.5 µM [26], [27]. A time course study with ?-mangostin treatments showed normal cellular functions were disrupted and that the expressions of MAP and AKT kinases and pERK changed over time. The time course also revealed that ERK was activated at early timepoints but then deactivated over a span of 48 h while the phosphorylation of JNK consistently increased and the phosphorylation of AKT consistently decreased. ?-Mangostin in combination with 5-fluorouracil, a component of both the FOLFOX and FOLFIRI regimens for colon cancer, decreased cell viability and MAP and AKT activity had a more pronounced effect than either of these agents individually [27]. In another colon cancer cell line, HCT 116 cells responded to combination treatments of ?-mangostin and betulinic acid and their cell viability was decreased more significantly with the combination treatment than with either of these two agents individually [28]. This combination also induced apoptosis and increased tumor suppressor p53 levels, DNA damage, and MAPK/ERK signaling pathways [28]. ?-Mangostin promoted apoptosis in COLO 205, MIP-101, and SW 620 colon cancer cells and displayed IC50s of 23.7, 27.6, and 47.6 µM after 24 h, respectively [29]. Watanapokasin et al. reported increases in phospho-p53 and Bax, two proteins involved in the regulation of AKT [29], [30].
- www.sciencedirect.com/science/article/abs/pii/S1043661821006162
Oridonin
- Extracted from the Chinese herb Rabdosia rubescens
- Is a natural compound with the structure of a tetracycline diter-penoid
- Exert antitumor effects and is widely used
- Oridonin effectively induced cell apoptosis of pancreatic cancer cells
- Nanosuspension was more effective than free oridonin on
- G2/M-phase cell cycle arrest
- Apoptosis in the PANC-1 human pancreatic cancer cell line
- Induces apoptosis and senescence
- By increasing hydrogen peroxide and glutathione depletion in colorectal cancer cells
- Autophagy preceded apoptosis in oridonin-treated MCF-7 human breast cancer cells
- In lung cancer patients, oridonin also suppressed
- Mammalian target of rapamycin (mTOR) signaling
- Supesed growth of lung cancer tumors
- Inhibition of mTORC1 may be an effective target
- www.spandidos-publications.com/10.3892/mmr.2016.4897
ratio of CBS to H2S plays a vital role in cancer progression, including in ovarian cancer [18] and breast cancercystathionine gamma-lygase (CSE) overexpression, another H2S-producing enzyme, has also been reported in melanomaH2S activates MAPK and caspase-3 to initiate apoptosis
Yam extract
- Can inhibit the proliferation rate of colon cancer H29 cells
- Reduce the proportion of CSC
- www.oatext.com/chinese-herb-in-the-treatment-and-regulation-of-cancer-stem-cells.php
