Interakce
Coffee may inhibit the hepatic metabolism
Antipsychotic medication
Clozapine
- Elevating serum clozapine levels
- Increasing the risk of toxicity
Theophylline
- Potentially increasing serum theophylline levels
Acetaminophen
- Increase the bioavailability of aspirin
- May partially explain its efficacy in enhancing their analgesic effects
Káva snižuje vstřebávání
Zhoršená absopce železa
- Polyphenols in coffee can bind nonheme iron and inhibit its intestinal absorption [12]
- Drinking 150–250 ml of coffee with a test meal
- Inhibit the absorption of iron by 24–73%
- Discontinuing coffee consumption
- Significantly improved the response to iron supplements in Guatemalan toddlers.
- To maximize iron absorption from a meal or iron supplements, concomitant intake of coffee should be avoided [12]
Zinc Absorption Impaired
- Dietary inhibitors of zinc absorption, particularly phytate, increase the risk of zinc deficiency
- Coffee has been found to inhibit the bioavailability of zinc in vitro by 21–32%
- One report that coffee appeared to inhibit zinc absorption in human volunteers
- Effect of foodstuffs on the absorption of zinc sulfate
- Discontinuation of coffee for 5 months did not affect plasma zinc levels in Guatemalan toddlers [12]
Caffeine + Other methylxanthines - zesílení NÚ
Beta-adrenergních léků
- Coffee enhance the effects and side effects of ß -adrenergic stimulating agents [12]
Epinephrine
Albuterol
Monoamine oxidase inhibitors
- Risk of hypertensive crisis in combination of coffee wtih monoamine oxidase inhibitors [12]
Zrychlení eliminace látek pitím kávy
Increases CYP1A2 activity in habitual caffeine consumption
- Zrychlené vylučování něterých látek [12]
Lithium
- May decrease serum concentrations of by enhancing its elimination [12]
Calcium
- Negative shift in calcium balance
Drugs that inhibit activity of CYP1A2
- Interfere with the metabolism and elimination of caffeine
- Increasing the risk of toxic effects
