CETP
CETP - Cholesterol esther transfer protein
- Key role in the metabolism of HDL
- Mediates the exchange of lipids between lipoproteins
- Resulting in the eventual uptake of cholesterol by hepatocytes
- Reverse cholesterol transport
- High plasma CETP concentration is associated with reduced HDL-C concentrations.
- CETP is a strong and independent risk factor for CAD.
- The G allele is associated with increased plasma CETP
- Lower HDL C and increased CVD risk
- GG genotype responds well to statin therapy
- The frequencies of rs708272 genotypes
- AA (homozygote), 0.21
- AG (heterozygote), 0.49
- GG 0.30
- Allele A frequency was 0.46
- Association of allele G with
- Low levels of high-density lipoprotein cholesterol
- A high index of atherogenicity in this population (p < 0.001 and p < 0.001, respectively).
- Allele G was significantly associated with the risk of myocardial infarction
- Among the male participants (odds ratio 1.96, 95% confidence interval 1.208-3.178, p = 0.008)
- In the study population (odds ratio 1.465, 95% confidence interval 1.028-2.087, p = 0.036).
- Rs708272 is associated with myocardial infarction in the white population of Western Siberia (Russia).
- pubmed.ncbi.nlm.nih.gov/31739638/
- Under the influence of high dietary fat intake resulting in
- Lower high-density lipoprotein cholesterol
- Higher serum triglycerides
- www.researchgate.net/publication/358246523_A_Nutrigenetic_Update_on_CETP_Gene-Diet_Interactions_on_Lipid-Related_Outcomes
