MUDr. Dana Maňasková


Vyhledávání na medicinman.cz
 

Zlepšující, podpůrné faktory a terapie

Varování

  • The majority of studies cited are in vitro studies, performed in glass on tissue from a living organism, or in vivo studies, performed on tissue not removed from a living organism (animal studies).
  • Most studies have not advanced to clinical trials on humans.
  • The few human studies cited are preliminary clinical trials.
  • Therefore, although results seem favorable or unfavorable, treat them with caution.
  • Neither the author nor publisher makes any medical claims for any of the herbs or natural products in this review or the tables.
  • This are just study notes
  • Note that some of the herbs described are deadly poisons and extremely dangerous.

Astragalus - Astragalus membranaceu

  • Breast, cervical, and lung cancer
  • Seems to enhance the immune system
    • Especially in cases of deficiency
    • By restoring suppressed T cell function (Chu, Wong, & Mavligit, 1988; Sun et al., 1983)
  • 1-30 g per day seem to be typical
  • Doses greater than 28 g might cause immunosuppression
  • On alert list of herbs and natural products with toxic effects
Herbs or Natural Products That Decrease Cancer Growth Part One of a Four-Part Series; Muriel J. Montbriand, PhD, RN; Downloaded on 08 28 2019. Single-user license only. Copyright 2019 by the Oncology Nursing Society. For permission to post online, reprint, adapt, or reuse, please email pubpermissions@ons.org


Beta-Sitosterol

  • A plant fat and phytosterol known as beta-sito-sterol
  • Several European prostate drugs
  • Block the growth of prostate cancer cells
  • Study on an androgen-dependent line of prostate cancer cells
    • Beta-sitosterol decreased cancer cell growth by 24%
    • Increased apoptosis four-fold
    • 50% increase in production of ceramide
      • An important cell membrane component believed to induce apopotosis [19]
  • Androgen-dependent line of human prostate cancer cells (PC-3 cell line) implanted in mice
    • 2% mixture of beta-sitosterol
      • Beta-sitosterol, as well as another phytosterol known as campesterol
        • Inhibited growth of the prostate cancer cells by 70% and 14%
      • Inhibited the invasion of the prostate cancer cells into Matrigel-coated membranes by 78% compared to controls
      • Tumor motility—was reduced by 60-93%
      • Adhesiveness and ability to form tumor clumps - reduced the binding of these cancer cells to laminin by 15-38% and to fibronectin by 23%
    • 2% mixture of cholesterol on these cells
      • Increased cell growth by 18% [19]
      • Increased invasiveness by 43%
      • Tumor mobility increased by 67% when in the cholesterol
      • Increased cell-binding to type IV collagen by 36% [19]
  • Phytosterols inhibited the growth and metastasis of these (PC-3) prostate cancer cells
  • Beta-sitosterol - much more effective than campesterol in most parameters assessed [19]
  • Beta-sito-sterol may induce the inhibition of tumor growth
    • By stimulating apoptosis
    • Arresting cells at different locations in the cell cycle
      • May involve alterations in reactive oxygen species
      • Production of prostaglandin
  • Suggested phytosterol dosage is 169 milligrams twice daily with or without food [19]
  • Activates the sphingomyelin cycle and induces apoptosis in LNCaP human prostate cancer cells
  • ß-sitosterol suppressed prostate cancer cell proliferation, migration and invasion, but had no or minor effects on adhesion [27]
  • Beta-sitosterol (BS)
    • Anticancer properties against
      • Breast cancer,
      • Prostate cancer,
      • Colon cancer,
      • Lung cancer,
      • Stomach cancer,
      • Ovarian cancer
      • Leukemia
  • BS interfere with multiple cell signaling pathways, including
    • Cell cycle, apoptosis, proliferation, survival, invasion, angiogenesis, metastasis and inflammation
www.tandfonline.com/doi/abs/10.1080/01635581.2015.1087042?scroll=top&needAccess=true&journalCode=hnuc20



Chloroquine



Deferoxamine


Zyflamend

  • Supercritical fluid (CO2)
  • Hydroalcoholic extracts of the herbs:
    • Rosemary (Rosmarinus officinalis L.).
    • Turmeric (Curcuma longa L.).
    • Ginger (Zingiber officinale Roscoe).
    • Holy basil (Ocimum sanctum L.).
    • Green tea (Camellia sinensis [L.] Kuntze).
    • Hu zhang (Polygonum cuspidatum Siebold & Zucc.).
    • Chinese goldthread (Coptis chinensis Franch.).
    • Barberry (Berberis vulgaris L.).
    • Oregano (Origanum vulgare L.).
    • Baikal skullcap (Scutellaria baicalensis Georgi).
  • Suspended in olive oil [20]
  • Zyflamend has been shown to
    • Suppress the expression of certain genes involved in the inflammatory response and in cancer progression
      • Cyclooxygenase 1(COX-1)
      • COX-2
      • 5-lipoxygenase (5-LOX)
      • 12-LOX
  • Single-agent anticancer activity
    • Improved cancer suppression when used with hormonal and chemotherapy agents.
  • Use of this supplement is not associated with serious toxicity or adverse effects.
  • Zyflamend may inhibit the growth of melanoma cells [20]
  • COXs are enzymes that convert arachidonic acid into prostaglandins, which are thought to play a role in tumor development and metastasis
    • COX-2, is activated during chronic disease states, such as cancer
  • Zyflamend may suppress activation of nuclear factor-kappa B (NF-kappa B) [20]
  • 2012, human prostate cancer cells were treated in vitro with Zyflamend
    • Zyflamend, at a concentration of 0.9 µL/mL, inhibited expression of both COX-1 and COX-2
    • 0.45 µL/mL, the degree of COX-2 inhibition was observed, but the level of COX-1 inhibition was reduced by 50%
    • 0.1 µL/mL, Zyflamend effectively inhibited growth of prostate cancer cells
      • Increased the level of caspase-3, a proapoptotic enzyme [20]
    • Prostate cancer cells used in the study (LNCaP cells, which are androgen sensitive) did not express high levels of COX-2
      • Effects on prostate cancer cells may result from a COX-independent mechanism [20]
  • Lipoxygenase isozymes 5-LOX and 12-LOX
  • 0.25 µL/mL to 2 µL/mL of Zyflamend produced decreases in 5-LOX and 12-LOX expression in PC3 prostate cancer cells
    • Inhibited cell proliferation and induced apoptosis
    • Decrease in Rb phosphorylation (Rb proteins control cell-cycle-related genes) [20]
  • 200 µg/mL
    • After 48 hours of treatment, a statistically significant reduction in cell growth was observed for Zyflamend-treated cells
  • Insulin-like growth factor-1 (IGF-1; 0–100 ng/mL) alone or in combination with Zyflamend (200 µg/mL)
    • IGF-1 alone exhibited statistically significant, dose-dependent increases in cell proliferation
    • IGF-1 and Zyflamend showed significant decreases in cell proliferation [20]
  • Zyflamend
    • Inhibits the expression of class I and class II histone deacetylases (HDAC)
    • Upregulated their downstream target p21 suppressor gene
    • Chinese goldthread and baikal skullcap appeared to be the most likely major contributors to the overall Zyflamend effect on HDAC expression [20]
  • Patient with HGPIN received Zyflamend 3 times daily for 18 months
    • Zyflamend did not affect this patient's PSA level
    • After 18 months, repeat core biopsies of the prostate did not show PIN or cancer [20]
  • 2009 phase I study designed to assess safety and toxicity, patients with HGPIN
    • Zyflamend (780 mg) 3 times daily for 18 months, plus combinations of dietary supplements
      • Probiotic supplement, multivitamin, green and white tea extract, Baikal skullcap, docosahexaenoic acid, holy basil, and turmeric
      • Zyflamend and the additional dietary supplements were well tolerated
    • After 18 months of treatment
      • 60% of the study subjects had only benign tissue at biopsy
      • 26.7% had HGPIN in one core
      • 13.3% had prostate cancer [20]
  • Mild heartburn was reported in 9 of 23 subjects
    • Resolved when the study supplements were taken with food
    • No serious toxicity or adverse events were reported in the study [20]
  • Zyflamend (New Chapter, Brattleboro, Vermont)
  • LNCAP cells Zyflamend
    • Inhibit COX-1 and COX-2, induce cell cycle inhibitory proteins including p21,
    • At concentrations of 0.8 mg/mL suppress AR expression [24]
    • Downregulates NF-?B gene products and NF-?B activation in
      • Lung cancer
      • Leukemia cell lines [24]
  • Synergism with
    • Bicalutamide in LNCaP cells
    • Gemcitabine in a mouse pancreatic cancer model [24]
    • Combination preparations are currently in clinical trials in prostate cancer (NCT00669656) [24]

Butyrate

  • Short-chain fatty acid produced by the gut microbiota during the fermentation of dietary fibers,
  • Inhibit HDACs class III
    • Affects post-translational modifications of histones (Delage and Dashwood, 2008; Morrison and Preston, 2016).
  • Butyrate has been shown to reduce the growth of
    • Hepatocellular carcinoma (Wang et al., 2013; Pant et al., 2017b),
    • Lung cancer (Amoedo et al., 2011),
    • Breast cancer (Chopin et al., 2004),
    • Pancreatic cancer (Farrow et al., 2003; Natoni et al., 2005),
    • Colon cancer cells
  • By increasing histone acetylation (Donohoe et al., 2012, 2014).
  • www.frontiersin.org/articles/10.3389/fchem.2022.948217/full

Česnek - Allium sativum

  • Vykazuje určitý inhibiční potenciál [15]
  • Family Alliaceae
  • Sulfur-containing constituents
  • Can lower the incidence of
    • Breast,
    • Colon,
    • Skin,
    • Uterine,
    • Esophagus,
    • Lung cancers
  • Ingesting 5 g/day of garlic
  • DATS was effective in decreasing prostate cancer multiplicity in the transgenic adenocarcinoma of the mouse prostate model [18]

HDAC2 inhibition


Melatonin has a scientific name of N-acetyl-5- methoxytryptamine

  • For cancer of the breast, brain, lung, prostate, head, neck, and gastrointes?tinal tract
  • Melatonin is also used for jet lag, insomnia, nicotine withdrawal, headache, hypertension, and other conditions.
  • Can decrease the incidence of cytokine-induced hypotension for patients with cancer.
    • Interleukin-2 and tumor necrosis factor
      • Examples of cyto?kines (Lissoni et al., 1996a)
  • Quick-release melatonin
    • May be beneficial in decreasing potential sleep disorders associated with conditions such as
      • Thrombocytopenia induced by chemotherapy or interleukin-2 (Bregani et al., 1995; Micromedex Healthcare Series, 2003; Lissoni et al., 1995, 1996b, 1999).
  • Beneficial in stabilizing disease for adults with solid tumors who do not respond to treatments or cannot receive treatments (Micromedex Healthcare Series; Lissoni et al., 1991, 1994a).
Herbs or Natural Products That Decrease Cancer Growth Part One of a Four-Part Series; Muriel J. Montbriand, PhD, RN; Downloaded on 08 28 2019. Single-user license only. Copyright 2019 by the Oncology Nursing Society. For permission to post online, reprint, adapt, or reuse, please email pubpermissions@ons.org


Melatonin + interleukin-2

  • Seems to improve survival for pa?tients with advanced solid tumors of the breast, gastrointesti?nal tract, kidney, liver, and lung and melanoma (

Melatonin + triptorelin pamoate

  • For prostate cancer, radiotherapy for glioblastoma

Micromedex

  • melatonin + interferon for renal cell cancer (Micromedex Healthcare Series).

Adverse effects of melatonin

  • Headaches, transient depression,
  • Daytime fatigue and drowsiness,
  • Dizziness, abdominal cramps,
  • Irritability (Micromedex Healthcare Series, 2003; Wagner, Wagner, & Hening, 1998)
  • Reduces alertness (Dollins et al., 1993, Micromedex Health?care Series)
  • Commercially available melatonin usually is synthesized in laboratories
    • Possible contamination
  • Optimal safe dose has not been established
  • 20-50 mg along with radiation or chemotherapy has been used for cancer treatment (Brzezinski, 1997; Micromedex Healthcare Series, 2003)
Herbs or Natural Products That Decrease Cancer Growth Part One of a Four-Part Series; Muriel J. Montbriand, PhD, RN; Downloaded on 08 28 2019. Single-user license only. Copyright 2019 by the Oncology Nursing Society. For permission to post online, reprint, adapt, or reuse, please email pubpermissions@ons.org




Oridonin

  • Extracted from the Chinese herb Rabdosia rubescens
  • Is a natural compound with the structure of a tetracycline diter-penoid
  • Exert antitumor effects and is widely used
  • Oridonin effectively induced cell apoptosis of pancreatic cancer cells
  • Nanosuspension was more effective than free oridonin on
    • G2/M-phase cell cycle arrest
    • Apoptosis in the PANC-1 human pancreatic cancer cell line
  • Induces apoptosis and senescence
    • By increasing hydrogen peroxide and glutathione depletion in colorectal cancer cells
  • Autophagy preceded apoptosis in oridonin-treated MCF-7 human breast cancer cells
  • In lung cancer patients, oridonin also suppressed
    • Mammalian target of rapamycin (mTOR) signaling
    • Supesed growth of lung cancer tumors
      • Inhibition of mTORC1 may be an effective target
  • www.spandidos-publications.com/10.3892/mmr.2016.4897

Rosemary extracts

  • Active compounds carnosic acid
  • Rosmarinic acid
  • Inhibit the proliferation of various human cancer cell lines, including
    • NCI-H82 (human, small cell lung carcinoma)
    • DU145 (human prostate carcinoma)
    • Hep-3B (human [black] liver carcinoma)
    • K-562 (human chronic myeloid leukemia)
    • MCF-7 (human breast adenocarcinoma)
    • PC-3 (human prostate adenocarcinoma)
    • MDA-MB-231 (human breast adenocarcinoma; Yesil-Celiktas et al. 2010)
  • Decrease in TNF-?-induced ROS generation and NF-?B activation
  • Enhanced TNF-?-induced apoptosis (Moon et al. 2010)
  • Carnosol
    • Was the most effective in reducing tumor proliferation
    • Induce apoptotic cell death in high-risk pre-B acute lymphoblastic leukemia (ALL; Dorrie, Sapala, and Zunino 2001)
    • Decrease in Bcl-2
    • Decreased the percentage of cell death in the pre-B ALL lines SEM, RS4;11, and REH when combined with cytarabine, methotrexate, or vincristine
      • Compared to these chemotherapeutic agents alone
        • Carnosol, and possibly other constituents in rosemary, may block the terminal apoptotic events induced by some chemotherapeutic drugs and therefore may decrease the effectiveness of some standard therapies for leukemia [18]
    • www.ncbi.nlm.nih.gov/books/NBK92774/

O úroveň výše

Poslední aktualizace: 10. 12. 2023 21:58:19