nemoci-sympt/KARDIOLOGIE/hypertenze/snizuje-tk
Tumeric
Study found a significant decrease in SBP in the turmeric group
- At the end of the trial compared with the baseline
- no significant difference in SBP between the two groups
- Curcumin was previously reported to prevent hypertension through its antioxidant and chelating properties (Bhullar et al., 2013).
- Curcumin contains a phenolic ring that neutralizes oxidant molecules such as OH and O2· and reacts with di-ketone groups when they are combined with OH· and H2O2;
- Can suppress the adverse effect of oxidative stress on the sympathetic system and can subsequently control blood pressure (Kukongviriyapan et al., 2016)
- SIRT1 inhibits the expression of angiotensin II receptor type I in vascular smooth muscle cells
- Prevents vasoconstriction and hypertension (Jalali et al., 2020)
- This effect of SIRT1 might explain the reduction in SBP observed in the turmeric group
- Which exhibited a significant increase in SIRT1 levels
- Khajehdehi (2012) reported that SBP was reduced in patients with lupus nephritis who received turmeric supplementation.
Our results also suggest that turmeric supplementation might increase serum adiponectin levels, although the change in adiponectin levels was not statistically different between the placebo and turmeric groups. PPAR? has been proposed to exert an anti-inflammatory effect through forming a heterodimeric complex with the retinoid X receptor alpha transcription factor and controlling adiponectin gene expression. Mechanistically, this process activates PPAR? expression. Therefore, PPAR?-mediated upregulation of and increase in adiponectin levels should lead to an increase in its antifibrogenic and anti-inflammatory effects in the liver (Lim and Kwon, 2010). In a randomized controlled trial, 8 weeks of curcumin supplementation increased serum adiponectin levels in patients with metabolic syndrome (Panahi et al., 2017). In another study of patients with type 2 diabetes mellitus, 6 months of curcumin supplementation (1,500 mg/d) increased adiponectin levels by 152% (Chuengsamarn et al., 2014).
Asparagus - chřest
- Amount of asparaptine (251 mg/kg fresh weight) was approximately fivefold higher than hydroxynicotianamine (47–50 mg/kg fresh weight), which is a natural ACE inhibitor. It was finally concluded that asparaptine is a natural ACE inhibitor as well as nicotianamine and its analog in Asparagus
- www.sciencedirect.com/topics/chemistry/nicotianamine
Mechanismy
- Dilatace cév
- HořčĂk
- Pružnost cév
- SnĂĹľenĂ firbotizace
- selen 100 ug 1-0-1
- Vitam. E
- Prevence hypertenze chornického stavu
- Anxitox.
- Diuretika
Rawolfia serpentina a vomitoria
- Nevhodné
- Separanda v uĹľĂvánĂ
Reseprin
- Silné hypotens. a sedativumu - nevhodné
Yohimbin
- Dialtace cĂ©v perif. - rektálnĂ ÄŤĂpky i na Rp. - dilatace cĂ©v v pánevnĂ oblasti - uĹľĂvá se i na povzbuzenĂ erekce, pĹ™edávkovánĂ halucinace
- NenĂ povolen prodávat v ÄŚR v doplncĂch stravy.... (?)
Ajmalin
- Slabé hypotensivum, antiarytmikum
- Psalo se na recept (ještě dnes ? )
Vinca minor - barvĂnek menšĂ
- V ÄŤr byla tradiÄŤnÄ› uĹľĂvána naĹĄ - sušená na snĂĹľenĂ TK - pomÄ›rnÄ› spolehlivá
- Vincamin a deriváty
- HypotenzivnĂ, antidiabeitickĂ© a sedativnĂ
- Snadné předávkovánà se - potenc. jedovatost
- Brčál barvĂnek - pĹŻdu pokryvná rostlina
Vinca rosea
- Vinkristin, vinblastin izolovány z toho
- SniĹľujĂ taky TK, ale nepouĹľĂvajĂ se tak
Hlohy různé druhy - hlohový list s květem
- DominantnĂ bylina na snĂĹľenĂ TK
- Dřevina
- Dlouhá tradice (větvičky hlohu na šaty ženichům na světbě)
- Od renesance v terapii - na vysokĂ˝ TK a cholerikĹŻm na zklidnÄ›nĂ
- Je tam i sedace
- C-glykosidnĂ flavonoidy a vitexin a jeho deriv.
- Vazodilatace koronárnĂch cĂ©v
- Vs. dĂky tomu sniĹľuje TK a pĹŻs. jako srdeÄŤnĂ tonikum
- Hypotenzivnà učinek prokázán i v metastudii
- Alvisan ÄŤaj - s hlohem
- "steal foenomen nebyl zkoumán" - účinek je slabĂ˝, asi to tĂm pádem nehrozĂ
HloĹľinky - plody hlohu
- Taky vitexinovĂ© glykosidy, ale pĹ™evaĹľujĂ spĂše proantokyanidiny - zÄŤervenánĂ plodu
- Jsou spĂše protizánÄ›tlivĂ©, diuretickĂ©, na tlak moc nepĹŻsobĂ
- účinky hloĹľinek jsou na TK mnohem slabšĂ
- V zimně sloužil i jako nouzová potravina
- Po přemrznutà zesládnou - hydrolýzou glykosidu - zesládnou a změknou, dost vit. C aj.
- VĂ˝roba marmelády (podobná jako šĂpková) - lepšà aĹľ ty pĹ™emrzlĂ© - jsou sladšĂ
- Po 6-8 týdnech by mohl být pozorován plný účinek
JmelĂ bĂlĂ©
- Plod je lepkavĂ˝ uvnitĹ™
- ParazitnĂ rostlina
- Cytotoxické vlastnsti - viscotoxiny (polypeptidy)
- V německu podáván i.v. při ter. nádorů
- P.o. podánà - rozštěpà se v žaludku a nefunguje
- SrdeÄŤnĂ jed
- V lidovĂ©m lĂ©ÄŤitelstvĂ tradováno na snĂĹľenĂ TK - tento efekt však neprokázán
Dary Natury Krevní tlak Bio 50 g:
- Plod hlohu (Crataegus laevigata)*
- Šípek (Rosa canina)*
- Srdečnice (Leonurus cardiaca)*
- Květ hlohu (Crataegus laevigata)*
- Kořen kozlíku (Valeriana officinalis)*
- List jahodníku (Fragaria vesca)*
- Nať jmelí (Viscum album)*
Čaj při hypertenzi (HK kurz fytoterapie 2024)
- Hloh květ s listem, bříza list, dobromysl nať, meduňka nať, levandule květ
Čajová směs na krevní tlak
- Hlohový květ s listem 40 - sedativní, flavonoidní látky přímo na srdce
- Zlepší okysličení, zklidní palpitace, zefektivnění metabolismu kardiomyocytů
- Březový list 20 - močopudné - flavonoidy urog.,
- Dobromyslová nať 15 - sedace, relaxace
- Medunkový list 15 - sedace, relaxace
- Levanduolvý květ 10 - sedace, relaxace
- Nálev - přelije se horkouo vodou, zakryje se aby neodešly silice
- Bezpečnostní hledisko ne těhotným a kojícím, žlučové kameny
- 3x denně max.
- Kokoška pastuší tobolka - diuretické úč.
Dietní sůl u hypertenze
- Chlorid sodný, chlorid sodný,
- Nespekave látky: uhličitam hořečnatý, steraran hořečnatý,
Podpůrná fytoterapie Dr. Landy na snížení krevního tlaku
Kopřiva
- Urtica dioica has traditionally been used in the control of cardiovascular disorders especially hypertension.
- www.sciencedirect.com/science/article/abs/pii/S0079610719300987
MR antagonismus / MR delece
- Zvyšuje aktivitu BAT,
- Indukuje hnědnutí tukové tkáně,
- Zlepšuje zánět tukové tkáně
- Chrání před kardiometabolickou dysfunkcí
Přírodní antihypertensiva ze skupiny ACEI
- ACE inhibitors activity, including some well-know medicinal and food species, such as cinnamon (Cinnamomum zeylanicum Blume or Cinnamomum verum J. Presl.), pepper (Capsicum spp.), olive (Olea europaea L.), hawthorn (Crataegus pinnatifida Bunge), black nightshade (Solanum nigrum L.), passion fruit (Passiflora edulis Sims) and grape (Vitis vinifera L).47,50,51 ACE inhibitors from natural products belong to several phytochemical classes, including flavonoids, xanthones, alkaloids, peptides, terpenes, and tannins. Some compounds have presented both AceIn and ACE2 inhibitor activity, for example, phenolic compounds like myricetin and quercetin glycosylated derivates.12,50–52 The ability to inhibit both, ACE and ACE2, is caused by their closely related active sites, which are distinct mainly in terms of the smaller intramolecular size of ACE2 sites.48,49
ACE and ACE2 inhibitors present amphiphilic molecular structures usually with an aromatic moiety, in order to enable their interaction with the protein, a similar pattern to the observed with SARS-CoV-1 inhibitors.21,22,24,39 Pharmacophere analysis of suggested natural metabolites capable to inhibit SARS-CoV-2 through ACE2 inhibitions usually have structural features in accordance with Lipinski's rule with molecular weight lower than 500 Da, less than 5 hydrogen bond donors and a log P under 5.51,53,54 The number of hydrogen bond acceptors were more variable among suggested phytochemicals against COVID-19, ranging until 20.51,53 For instance, ACEIn peptides have as first residue an aromatic amino acid, and the third is a hydrophobic one.49 The sequence trending necessary for peptides to be ACEIn was extensively exploited by Daskaya-Dikmen et al. (2017).49
- Glycosylated derivates of quercetin to present promising inhibition activity with lower binding energy than -8.3 kcal mol-1.51,53 These flavonoids, described by Joshi et al. (2020)51 includes quercetin-3-glucuronide-7-glucoside and quercetin 3-vicianoside, which can be found in Indian long pepper (Piper longum L.), turmeric (Curcuma longa L.) and wormwood (Artemisia absinthium L.)