nemoci-sympt/BAKTERIALNI-INFEKCE/chlamydie/symptomy-a-asociovana-onemocneni/sekundarni-borrelioza
Sekundární porfýrie
- Teoretické souvislosti
- Cpn interferes with the heme pathway
- Secondary porphyria further exacerbated under treatment
- Chronic symptoms may be due to heme byproducts [31]
- Heme is a Fe2+ complex
- Biosynthesis of heme occurs in all human cells
- Porphyrinogeny - toxické meziprodukty
- Transitional phase of the heme biosynthesis pathway
- Quickly transformed into heme
- Porphyrias = consequences of:
- X formation of porphyrinogens
- X transformation porfyrinogens to heme
- Chlamydiae
- mitochondrial matrix final steps in the biosynthesis of heme are halted
- Porphyrins accumulate in the cell, then extracellular [31]
- Depletion of host cell energy by the intracellular infection with Chlamydia
- Not enough ATP to transport Hem prek. and Hem ? [31]
- Unstable heme precursors and porphyrins inside and outside cells
- Free radical damage and reduced ATP (energy) synthesis [31]
Symptoms of Porphyria
Nervous system:
- Chest pain
- Shortness of breath
- Abdominal pain
- Nausea
- Muscle cramps
- Weakness
- Hallucinations
- Depression
- Anxiety
- Paranoia
- Seizures
Skin
- Blisters
- Itching
- Swelling
- Sensitivity to the sun (can be caused by some antibiotics too)
- Purple-red-colored urine [31]
- Stratton's protocol suggests
- Testing for porphyrins prior to treatment
- Initiating nutritional and other interventions prior to starting treatment for Cpn
- To help prevent or limit secondary porphyria [31]
Porfyriny, které jsou asociované s klin. sympt.
- water-soluble porphyrins
- Delta-aminolevulinic acid
- Porphyrobilinogen
- fat-soluble porphyrins
- Coproporphyrin III
- Protoporphyrin [31]
- Presence of porphyrins in an individual patient with chronic/systemic chlamydial infection
- Confirmed pre- and during therapy
- In 24-hour urine test
- In 24-hour stool tests
Stratton & Mitchell's THERAPY OF CHRONIC CHLAMYDIAL INFECTIONS INCLUDING THEIR ASSOCIATED PORPHYRIA AND VITAMIN B12 DEFICIENCY: SEVENTH VERSION [31]
- Measuring B-12 deficiency
- Directly B12 in blood
- From blood elements
- Serum methyl malonate
- Elevated in B12 deficiency, not changed by folate [31]
- Homocystine levels [31]
- Ovlivněn k. listovou
- High hemoglobin
- High hematocrit
- "Poor Man's" Porphyrin Test According to Chuck Stratton :
- Dark urine after taking metronidazol
- Put their urine in a clear glass container outdoors in the sun for several hours
- If the color gets darker (copper-purple color)
- It is due to porphyrins [31]
