Doplňky, byliny, vitamíny
Roseomonas mucosa
- Is a bacterium found in healthy skin,
- Recent research suggests that it may be beneficial in treating atopic dermatitis (eczema).
- It works by
- Promoting a healthy skin microbiome,
- Reducing inflammation,
- Restoring skin barrier function.
- Clinical trials have shown promising results, with improvements in skin lesions and overall symptoms after several months of therapy.
- This approach is part of a broader field exploring the use of live biotherapeutics to manage chronic skin conditions.
- Klinické studie:
- Momentálně je Roseomonas mucosa dostupná pouze prostřednictvím klinických studií. Některé univerzity a výzkumné instituce se zaměřují na testování této bakterie v terapiích kožních onemocnění. Pokud máte zájem o účast v klinické studii, doporučuji hledat na stránkách univerzit nebo výzkumných center, které se věnují dermatologii nebo probiotikům.
- Výzkumné laboratoře:
- Některé biotechnologické firmy nebo laboratoře mohou prodávat bakteriální kmeny pro výzkumné účely. To však obvykle není určeno pro osobní použití, ale pro vědecký výzkum v kontrolovaných podmínkách.
- Specializované e-shopy:
- Pokud byste hledal bakteriální kmeny pro vědecký výzkum, jsou specializované e-shopy (např. ATCC nebo DSMZ), které prodávají mikrobiální kmeny. Opět platí, že jsou tyto produkty určeny především pro výzkumné účely.
Ajurvedská terapie
Panchkarma procedures are proven to be beneficial in many allergic and immune-related pathologies such as urticaria, psoriasis, and bronchial asthma. Eczema usually considered a chronic dermatological disorder, highly recurrent in nature. Few Ayurvedic studies have suggested that Rasayana drugs should be supplemented in such recurrent conditions.[6] As most of the recurrent diseases including eczema are immune-mediated, Brahma rasayana has been preferred in the management. Brahma rasayana is a polyherbal formulation with action on cardio-vascular system, the central nervous system, and is proven antioxidant.[8,9]Patola katu rohinyadi kashaya is mainly indicated in liver diseases, psoriasis, allergic dermatitis, pemphigus vulgaris, viral infections, etc. It pacifies Pitta and Kapha doshas. Nalpamaradi keram oil is mentioned in Ashtanga hridayam for topical application in various infective and allergic skin lesions. It is a polyherbal preparation containing Pancha kshiri vriksha (Vata [Ficus bengalensis L.], Udumbar [Ficus racemose L.], Ashwatth [Ficus religiosa L.], Pluksh [Ficus virens (Miq.) Corner], and Pippalbhed/Hibinuxvs [Thepasia populnea (L.) Sol. ex Correa]), Triphala (Amalaki [Emblica officinalis Gaertn], Vibhitaka [Terminalia bellerica (Gaertn.) Roxb], and Haritaki [Terminalia chebula (Gaertn). Retz]), Rakta chandana (Pterocarpus santalinus L.), Usheer (Vetiveria zizanioides [Linn.] Nash), Kushtha (Saussurea lappa [Decne.] Sch. Bip.), Manjishtha (Rubia Cordifolia Linn.), Haridra (Curcuma longa Linn.), etc., processed in the presence of coconut oil. It is helpful in preventing bacterial, fungal, or environmental allergens to breach the skin barrier.[10] Pancha valkala kwatha and Triphala kwatha also cleans and soothe the skin and prevent harmful biofilm, if applied locally.[11,12] Arogyavardhani vati and Kaishora guggulu are blood purification agent and are used specially in skin disorders.[13,14] This combination has been reported to be highly effective in serous erythroderma lesion.[13]
In this present study along with these Shodhana (~major purification therapies), the Prasamanam (~subsiding the disease) Aushadhi have supported in attaining better results in this case. The outcome infers that Ayurvedic management provides substantial relief and improves the quality of life of patients with conditions such as chronic eczema.
CONCLUSIONThe present observations provided some leads toward Ayurvedic management approaches in conditions such as lichenoid dermatitis. In chronic recurrent dermatological diseases, herbal or Ayurvedic medicines can be safely used for the long term without any harm. Considering the encouraging results of the treatment strategies, well-designed studies can be initiated to establish efficacies in a larger sample size.
Zvýšení aktivity Delta-6-desaturázy
- Enzyme responsible for converting the essential fatty acid alpha-linolenic acid (ALA) into its longer-chain derivatives
- Eicosapentaenoic acid (EPA)
- Docosahexaenoic acid (DHA)
- These omega-3 fatty acids have numerous health benefits.
Increase intake of ALA-rich foods
- Foods rich in alpha-linolenic acid
- Substrate needed for delta-6-desaturase
- Flaxseeds, chia seeds, hemp seeds, walnuts, and leafy green vegetables.
Optimize omega-6 to omega-3 ratio
- Delta-6-desaturase is responsible for converting both omega-3 and omega-6 fatty acids
- Excessive intake of omega-6 fatty acids, commonly found in vegetable oils like soybean oil and corn oil
- Can compete with omega-3s for conversion
Consume preformed EPA and DHA
- Delta-6-desaturase converts ALA into EPA and DHA
- Conversion efficiency is limited in some individuals
- Ensure an adequate intake of EPA and DHA
- Fatty fish (salmon, mackerel, sardines)
- Algae-based supplements
- Fish oil supplements.
Minimize alcohol and trans fat consumption
- Excessive alcohol intake and trans fats is associated with reduced delta-6-desaturase activity
- Limiting alcohol consumption
- Avoiding trans fats found in processed foods can support optimal enzyme function.
Manage inflammation
- Chronic inflammation can interfere with delta-6-desaturase activity
- Anti-inflammatory diet rich in fruits, vegetables, whole grains, and healthy fats can help reduce inflammation and promote enzyme function.
Mmagnesium, zinc, and certain B vitamins
- Role in the activity of delta-6-desaturase
NADH (Nicotinamide adenine dinucleotide, reduced form)
- Serves as an electron carrier in the reaction catalyzed by delta-6-desaturase.
FADH2 (Flavin adenine dinucleotide, reduced form)
- Similar to NADH, FADH2 also acts as an electron carrier during the enzymatic reaction.
Iron
- Play a crucial role as cofactors in many enzymes, including delta-6-desaturase
- Involved in the oxygenation process, which is necessary for the desaturation of fatty acids.
Cytochrome b5
- A membrane-bound protein
- Co-factor for delta-6-desaturase
- Helps in the transfer of electrons during the enzymatic reaction.
Cytosolic factors
- Are believed to be essential for the optimal activity of delta-6-desaturase
- May include specific proteins or other components that contribute to the overall function of the enzyme.
Vitamin C (kyselina askorbová)
- Může působit jako kofaktor delta-6-desaturázy a podporovat její aktivitu.
Vitamin B3 (niacin)
- Niacin je nezbytný pro různé enzymatické reakce v těle, ačkoli jeho přesná role jako kofaktoru delta-6-desaturázy ještě není zcela jasná.
Vitamin B6 (pyridoxin)
- Může mít vliv na aktivitu delta-6-desaturázy.
Riboflavin (vitamin B2)
- Může hrát roli jako kofaktor delta-6-desaturázy.
- Výčet všech kofaktorů a jejich specifické role v aktivitě delta-6-desaturázy může být stále předmětem výzkumu
Lactobacillus rhamnosus
- Effects have been most consistent with combined prenatal and direct postnatal supplementation of the infant and appear strain-specific, with Lactobacillus rhamnosus most often showing an effect.
- Prenatal-only and postnatal-only studies often fail to show effects. Recent long-time follow-ups have shown promising but not consistent results. A very recent follow-up of a large well conducted cohort shows that long-term effects of eczema prevention persists until age 4 and prevention of respiratory allergies might also be possible.
- Prevention of eczema with probiotics seem to work until age 2 years and extended effects until 4 years have been shown in high-risk for allergy cohorts. Effects are strain-specific, with L. rhamnosus showing the most consistent effects especially when combining pre and postnatal administration.
- journals.lww.com/co-allergy/abstract/2013/06000/probiotics_and_prebiotics_in_preventing_food.12.aspx
Maitake
- Po zahájení užívání doplňku s maitake jednomu klientovi uplně zmizel ekzém
ref. Jakub Přibyl
