Podpora a stimulace růstu a udržení vlasů

5alpha-reductase inhibitory activity (FEA)

• Testosterone 5alpha-reductase is an enzyme catalyzing the conversion of testosterone to dihydrotestosterone
• Possesses high affinity for the androgen receptor [23]
• Vhodné u androgenní alopecie
• Strong relationships between 5alpha-reductase inhibitory activity and:
• Hair growth promoting activity
• Hair follicle count
• Vliv testované látky a rostlin lze vyjadřovat jako:
• Finasteride equivalent 5?-reductase inhibitory activity (FEA) [17]

Carthamus tinctorius L.

• Most potent 5alpha-reductase inhibitor
• FEA of 24.30 ± 1.64 mg finasteride equivalent per 1 g crude extract
• Most potent hair growth promoter in C57BL/6 mice

Phyllanthus emblica L.

• Second most potent inhibitor
• FEA of 18.99 ± 0.40 mg

Rhinacanthus nasutus (L.) Kurz.

• FEA 10.69 ± 0.96

Puerariae Flos

• Flowers of Pueraria thomsonii
• Its potent inhibitory activity
• 50% ethanolic extract of Puerariae Flos (PF-ext)
• Inhibitory activity of 60.2% at 500 µg/ml against testosterone 5?-reductase [23]
• More potent than that of Puerariae Radix (roots of Pueraria lobata)
• PF-ext also showed in vivo anti-androgenic activity
• Saponins active components in PF-ext
• Soyasaponin I
• Kaikasaponin III [23]
• Hair growth promotion activity in C3H/He mice at 2 mg/mouse/day of the topical administration of PF-ext was demonstrated [23]

Agafia šampon na vlasy proti vypadávání 260 ml

• Aqua (voda)
• Sodium Coco-Sulfate (tenzidy z kokosového oleje)
• Cocamidopropyl Betaine (tenzidy)
• Sodium Chloride (kuchyňská sůl)
• Arctium Lappa (Burdock) Root Extract (extrakt z lopuchu většího)
• Urtica Dioica (Nettle) Extract (extrakt z kopřivy dvoudomé)
• Pinus Sibirica (Siberian Pine) Needle Extract (extrakt z jehličí sibiřské borovice)
• Panthenol (provitamin B5)
• Guar Hydroxypropyltrimonium Chloride (změkčovadlo)
• Citric Acid (kyselina citronová)
• Parfum (parfemace)
• Benzyl Alcohol (konzervant)
• Sodium Benzoate (konzervant)
• Potassium Sorbate (konzervant)
• Limonene (vonná látka)
• Linalool (vonná látka)
• Šampon obsahuje silikony.
• Neobsahuje parabeny.

CAVE:

• Sodium Coco-Sulfate:
• Jedná se o silnou mycí látku, která může vlasy zbavit přirozených olejů a oslabit je, čímž je náchylnější k vypadávání.
• Silikony:
• Silikony se sice používají k tomu, aby vlasy zjemnily a dodaly jim lesk, ale mohou také vlasy zatěžovat a bránit jim v dýchání. To může vést k oslabení vlasů a jejich vypadávání.
• Parfemace a vonné látky:
• Parfemace a vonné látky v šamponu mohou u citlivých osob vyvolat alergické reakce a podráždění pokožky hlavy, které může vést k vypadávání vlasů.

Bestatin

• An aminopeptidase inhibitor, promotes follicular growth and ovulation suppressed by stress in mice
• pubmed.ncbi.nlm.nih.gov/9881905/

Hairmenn

Nolopecia

• For stimulating hair growth

Saw palmetto: Saw palmetto has been traditionally used to help with hair loss and improve hair growth.
Rosemary: Rosemary has been found to have antimicrobial properties, which can help to improve the health of the scalp and promote hair growth.
Nettle: Nettle has been traditionally used to help with hair loss, improve the health of the scalp, and promote hair growth.
Horsetail: Horsetail is a rich source of silica which is a mineral that helps in strengthening the hair and improving its growth.
Aloe vera: Aloe vera has been found to have anti-inflammatory properties, which can help to soothe the scalp and promote hair growth.
Green tea: Green tea contains antioxidants that can help improve the overall health of the scalp, promoting hair growth.

Allium cepa extract

• Found to promote hair growth
• Antioxidant capacity as the contributing factor [27]

Bimatoprost

• Prostaglandin analogues
• Widely used to treat glaucoma
• Variable success when used as eye drops to stimulate eyelash growth in alopecia areata
• Likely work by interacting with the prostaglandin receptors in the hair follicle
• Inducing anagen (growth phase) in telogen (resting phase) follicles [25]
• Eye drop for glaucoma, eyelash growth was noted in 42.6% of patients treated once daily for a year
• Bimatoprost for hypotrichosis of the eyelashes - US FDA approval in 2008 [25]

Biosil

• Zdroj křemíku

Zklidňující šampon s jogurtovými kulturami, růžovým olejem a ureou 8% proti vypadávání vlasů.
Výjimečně šetrný šampon k efektivní prevenci vypadávání vlasů. Šetrně čistí, oživuje a přidává vlasům lesk, obnovuje přirozenou rovnováhu pokožky hlavy a vlasů. Obsahuje aktivní složky působící hluboce a intenzivně proti vypadávání vlasů. Šampon revitalizuje vlasy od kořínků ke konečkům, vlasy jsou silnější, pevnější a lépe se udržují.
Je určen pro šetrné mytí suché, citlivé pokožky hlavy se sklonem k podráždění a zánětlivým stavům. Pro všechny typy vlasů. Obsahuje ureu, která hydratuje pokožku hlavy a zanechává ji hladkou a vyživenou.
ÚČINNÉ LÁTKY:
růžový olejureaprobiotické kultury / hydrolizovaný jogurtový proteinkreatinUREA/Močovina je organická sloučenina, kterou vytvoří tělo po metabolizaci bílkovin, a která se následně vyloučí z těla v moči a potu. Může být také ale vyrobena synteticky. Jedná se o přirozenou složku tkáně. Tvoří 7 % naší přirozené hydratace pokožky, nevýhodou je, že její zastoupení v kůži s věkem klesá, což se projevuje na zhoršení elasticity pleti. V kosmetice se používá kvůli tomu, že udržuje hydratovanou pleť, zamezuje ztrátě vlhkosti, působí proti známkám stárnutí a zároveň udržuje vyrovnané pH pleti. Mění strukturu pokožky a napomáhá lepšímu pronikání účinných látek do jejích vrstev. Kůže je po jejím použití měkká a vláčná, močovina totiž zabraňuje jejímu šupinatění a olupování se.
Země původu – Bulharsko
Výrobce – Bio Fresh Ltd.
SLOŽENÍ:AQUA, SODIUM LAURETH SULFATE, UREA, SODIUM COCOAMPHOACETATE, COCAMIDOPROPYL BETAINE, ACRYLATES COPOLYMER, COCAMIDOPROPYL BETAINAMIDEMEA CHLORIDE, PEG-7 GLYCERYL COCOATE, DIMETHICONOL, SODIUMDODECYLBENZENESULFONATE,C11-15 PARETH-12, COCAMIDE DEA, POLYQUATERNIUM-44, PEG-4 DISTEARYL ETHER,SODIUMLAURETH SULFATE,DISTEARYLETHER,DICAPRYLYL ETHER, SODIUM CHLORIDE, CREATINE, PARFUM, HYDROLYZED YOGURT PROTEIN, LACTIC ACID, METHYLCHLOROISOTHIAZOLINONE,METHYLISOTHIAZOLINONE, ROSA DAMASCENA FLOWER OILhttps://www.gobra-nails.cz/produkt/yoghurt-probiotic-urea-sampon-proti-vypadavani-vlasu-230ml/

Alopecia
Essential oils have been studied in a randomized, controlled, double-blind study of 86 patients with alopecia areata (Hey, Jamieson, and Ormerod 1998). A mixture of essential oils including thyme, rosemary, lavender, and cedarwood in carrier oils with grape seed and jojoba (a liquid wax) was massaged into the scalp daily. The control group massaged only the carrier oils into the scalp. Success was evaluated on the basis of sequential photographs, by both a six-point scale and a computerized analysis of areas of alopecia. The treatment group had a statistically significant improvement over the control group (44% vs. 15%). There were no reported adverse effects.
A double-blind study that lasted 6 months and in which 396 patients participated evaluated the topical use of a Chinese herbal formula, Dabao (manufactured by Engelbert & Vialle, Venlo, Netherlands), for the treatment of androgenic alopecia (Kessels et al. 1991). The ingredients of Dabao include 50% ethanol, 42% water, and 8% Chinese herbal extracts, including saffron flowers, mulberry leaves, stemona root, fruits of the pepper plant, sesame leaves, skin of the Szechuan pepper fruit, ginger root, Chinese angelica root, bark of the pseudolarix, and fruit of the hawthorn plant. The ingredients of the placebo included 50% ethanol, 48% water, and 2% odorizing and coloring agents consisting of cherry laurel water, cinnamon water, licorice syrup, sugar syrup, and a solution of burned sugar. In both groups, there was an increase in nonvellus hairs. Although the Dabao group was statistically superior to the placebo group in number of nonvellus hairs, the cosmetic improvement in both groups was minimal. There were no reported adverse effects. Other TCM herbal mixtures have also been used for alopecia areata (Xu 2004).https://www.ncbi.nlm.nih.gov/books/NBK92761/

Cedar wood oil

Cell Therapy - Called platelet rich plasma (PRP)

• Small amount of your blood is spun in a centrifuge
• To separate the platelets and growth factor proteins
• Added to your scalp
• Helps increase blood flow to the scalp
• Can reawaken dormant hairs to stop active hair loss
• Used with a hair transplant speeds the healing process [11]

Eclipta alba Hassk.

• Well-known Ayurvedic herb
• Petroleum ether and ethanol extract of E. alba Hassk effect on promoting hair growth in albino rats
• Into oleaginous cream (water in oil cream base) and applied topically on shaved denuded skin of albino rats [21]
• Minoxidil 2% solution was applied topically and served as positive control for comparison
• Hair growth initiation time was significantly reduced to half on treatment with the extracts, as compared to control animals
• Quantitative analysis of hair growth
• Petroleum ether extract (5%) exhibited greater number of hair follicles in anagenic phase (69 ± 4)
• Higher as compared to control (47 ± 13) [21]
• 2 and 5% petroleum ether extracts results were better than the positive control minoxidil 2% treatment [21]

Estrogens

• Systemic estrogens increase production of the glycoprotein sex hormone-binding globulin (SHBG)
• Leading to a decrease in free testosterone [25]
• 6 month study of a topical 17alpha -estradiol 0.025% preparation applied by 7 women with FPHL
• Reported stabilization of hair loss and/or increased telogen hair shedding
• Compared to 2 female control subjects [25]

FGF-7 expression

Finasteride

• May lead to impotence, loss of interest in sex, trouble having an orgasm, and abnormal ejaculation [26]

Fluridil

• Synthetic novel topical antiandrogen
• Similar in structure to flutamide
• Highly hydrophobic
• Systemically non-resorbable compound
• Demonstrates local tolerance
• Degrades into inactive metabolites without systemic antiandrogenic effects
• Double-blind, placebocontrolled study of 43 men with AGA, fluridil:
• At 3 months increased anagen percentage from 76% to 85% in the fluridil treated group
• At 9 months to 87%
• no change in the placebo group [25]
• Sexual function, libido, hematology and blood chemistry values were normal [25]

Flutamide

• High incidence of feminizing side effects and are better tolerated in female androgenic hair loss [26]

Geranium sibiricum L.

• Medicinal plant to treat diarrhea, bacterial infection, and cancer in Bulgaria, Peru, and Korea
• Hair growth-promoting effect [27]

• GSE treatment
• Proliferated and migrated human dermal papilla cells (hDPCs) more than treatment of 10 µM minoxidil
• Stimulated the expression of
• Ki-67 protein
• MRNA levels of hepatocyte growth factor
• Vascular endothelial growth factor in hDPCs [27]
• Topical application of 1,000 ppm GSE for 3 weeks
• Promoted more significant hair growth on shaved C57BL/6 mice than did 5% minoxidil [27]
• The histological
• Active anagen phase with the induction of stem cell factor
• Reduced the number of mast cells
• Reduced expression of transforming growth factor beta 1 in mouse skin tissues [27]

• Ethanol extract of Geranium sibiricum L.
• Decreased expression of
• Interleukin 1 beta (potent inhibitors of hair growth in vitro and in vivo) [27]
• COX-2 (potent inhibitors of hair growth in vitro and in vivo) [27]
• Inducible nitric oxide synthase (iNOS) in PMACI stimulated HMC-1 cells

• Dihydrotestosterone (DHT), contributing to androgenic alopecia
• Increases iNOS from occipital dermal papilla cells
• INOS and NO are downstream effectors of androgen receptors [27]

• Antioxidant activity was shown by scavenging various radicals effectively
• Corilagin
• Gallic acid [27]

• Gallic acid
• Could prevent allergic reaction by blocking histamine release and pro-inflammatory cytokine expression in mast cell [27]

Ketoconazole

• Imidazole antifungal agent
• Effective for the treatment of seborrheic dermatitis and dandruff
• 21 month study comparing topical ketoconazole to minoxidil
• Ketoconazole 2% shampoo
• Unmedicated shampoo
• Unedicated shapoo + minoxidil 2% [25]
• Hair density and size as well as proportion of anagen follicles
• Improved almost similarly by both ketoconazole and minoxidil regimens
• Mechanism by which ketoconzole improves hair growth is unclear:
• Anti-inflammatory effects against T cells
• Found in the balding area in AGA [25]
• Activity against microflora of the skin by Malassezia
• Inhibits steroid synthesis
• Decreases DHT levels at the hair follicle by affecting androgen receptor activity [25]

Kolagenotvorné bílkoviny / aminokyseliny

Chondroitinsulfát

Chondrosulf

• Pozorovala jsem sama na sobě silnější nehty a rychlejší růst vlasů i nehtů a nebyla sem sama :)

Laser Light Therapy

• Encourages the protein synthesis needed for hair regeneration [11]
• Stimulates blood flow to the area for better growth
• 80 % of people treated with lasers for hair loss have a decrease in shedding or complete stopping of hair loss
• 40 % get thicker hair [11]

Latanoprost

• Prostaglandin analogues
• Widely used to treat glaucoma
• Variable success when used as eye drops to stimulate eyelash growth in alopecia areata
• Likely work by interacting with the prostaglandin receptors in the hair follicle
• Inducing anagen (growth phase) in telogen (resting phase) follicles [25]
• A 24 week double-blind, randomized pilot study of 16 men with mild AGA
• Significant increase in hair density (terminal and vellus hairs) on the treated site with latanoprost 0.1%
• Compared to baseline and the placebo-treated area [25]
• Well tolerated
• Erythema at the application site was observed in 5 patients [25]

Lavender oil

Masáže skalpu s kokosovým olejem

• Možno přidat další ingredience
• A domácí vlasové masky s protizánětlivými ingrediencemi, vitamíny rozpusnými v tucích, s rozemletými bylinami,...

Masky

• Vejce žloutek - ne bílek (CAVE: avidin - dělá výpad vlasů - blokuje biotin)!
• Kopřivy
• Březové listí
• Hloh
• Další domácí léčivé přísady dle možností

Princip

• Vyživit, prokrvit, desinfikovat, tlumit zánět

Melantonin

• Long been known to modulate hair growth
• Animal testing
• melatonin stimulates the anagen phase of hair growth [25]
• Double-blind, randomized, placebocontrolled study 40 women with diffuse alopecia (n=28) or AGA (n=12)
• Treated topically for 6 months with 1 ml daily of 0.1% melatonin-alcohol solution versus vehicle
• Trichograms were used to determine efficacy in the frontal and occipital scalp areas
• AGA group
• Statistically significant increase in anagen hairs in the occiput region compared to placebo
• no difference was shown with placebo in the frontal area [25]
• Diffuse alopecia
• Substantial increase in frontal hair [25]
• Plasma melatonin levels were elevated under treatment with melatonin, but did not exceed the physiological night peak [25]

Minoxidil (MXD)

• Three kinds of topical dosage forms of minoxidil
• Vesicles
• Double emulsions
• Inclusion complex with hydoxypropyl- ß-cyclodextrin (HP- ß-CD) [18]
• The skin retention was the highest when the drug was encapsulated in cationic vesicles
• Ionic interaction between the cationic vehicle and negatively charged skin
• Likely responsible for the relatively high skin retention [18]
• Nonionic vehicle left no significant amount of the drug after rinsing the skin
• The double emulsion
• HP- ß-CD [18]
• Only MXD in the cationic vesicles had hair growth promotion effect
• Due to significant skin retention [18]

• Quantitative growth of hair over a 40-week period in 8 women with androgenetic alopecia
• Random, double-blind protocol
• 2% minoxidil solution or a placebo [20]
• Total hair weight of minoxidil-treated subjects increased over the 32-week test period by 42.5%
• Compared to 1.9% for the placebo-treated subjects [20]

• Topical minoxidil shortens telogen
• Premature entry of resting hair follicles into anagen
• May also cause prolongation of anagen and increases hair follicle size [22]

• Orally administered minoxidil
• Lowers blood pressure by relaxing vascular smooth muscle through the action of its sulphated metabolite
• Minoxidil sulphate
• Opener of sarcolemmal KATP channels [22]
• Stimulatory effect of minoxidil on hair growth
• Also due to the opening of potassium channels by minoxidil sulphate
• Difficult to prove
• no clear demonstration that KATP channels are expressed in the hair follicle [22]
• Stimulation of cell proliferation
• Inhibition of collagen synthesis
• Stimulation of vascular endothelial growth factor
• Stimulation of prostaglandin synthesis
• Results obtained in cell culture studies x complex biology of the hair follicle is uncertain [22]

• Minoxidil is the current standard treatment for hair loss
• Initially used as an oral antihypertensive medication
• Side effect of hypertrichosis = developed as a topical treatment in 2% strength for hair loss [25]
• 2% formulation in 1988
• 5% in 1997
• Precise mechanism by which minoxidil induces hair growth is unknown
• Vasodilatory
• Angiogenic
• Enhanced cell proliferative effects [25]
• Adenosine-triphosphate-sensitive potassium channel opener
• Stimulate the production of vascular endothelial growth factor
• Possible promoter of hair growth [25]
• Prolongs duration of anagen of the hair cycle
• Ability to maintain and thicken preexisting hair
• Increases miniaturized hair follicle size [25]

• Proven in doubleblind, placebo-controlled trials
• Men with MPHL
• Minoxidil showed a rapid increase in hair count and weight peaking at 16 weeks
• Average increase in target area hair count is about 8% with minoxidil 2% lotion
• 10-12% with the 5% formulation [25]
• About 60% of men demonstrated improvement with the 5% formulation
• Cca 40% with the 2% formulation
• Compared with 23% of placebo [25]

• In women with FPHL treated with minoxidil
• 2% solution
• 10-16% increase in regrowth compared with controls
• Greater effects may be derived at 5% concentration [25]

• Treatment is life-long
• Stopping minoxidil will shed all minoxidil-dependent hair growth within 4 to 6 months [25]

Recommended dosing

• 2% or 5% minoxidil solution
• 2xd 1 ml (25 drops) spread evenly over the entire top of the dry scalp
• 5% foam formulation
• Half a capful 2xd on the dry scalp, left in place for at least 4 h
• Minimize the risk of hypertrichosis of the face
• Hands should be washed with warm water after application [25]

Safety profile

• High
• Adverse effects are very infrequent
• Skin irritation, contact dermatitis, facial hypertrichosis, scale
• Dryness, tachycardia
• Transient increased hair shedding [25]
• Constituents of the vehicle
• Propoylene glycol and minoxidil
• Can cause irritant contact dermatitis
• Allergic contact dermatitis
• Exacerbation of seborrheic dermatitis [25]
• More common with the 5% solution
• 5% foam vehicle is propylene glycol free
• Reduces the potential for irritation
• Improves cosmetic acceptability [25]

Tuky

• Dostatek tuků ve stravě souvisí i s kvalitou kůže i vlasů
• Pro syntézu kožních ceramidů jsou potřeba omega-6 MK

Polygonum multiflorum

Polygonum multiflorum Radix (PMR)

Polygonum multiflorum Radix Preparata (PMRP)

• Long history for hair growth and hair dying in clinical applications
• P. multiflorum was recorded as an extremely tonic medicine in traditional Chinese medicine
• Few studies have shown that P. multiflorum extract could promote the quiescent C57BL/6J mice hair follicles to enter anagen stage earlier
• Sonic Hedgehog (SHH) protein
• ß-catenin expression levels were significantly increased in mice after topical application of PMR and fermented products [26]
• In vitro pig hair follicle cell culture model, PMR decoction
• Inhibit hair follicle apoptosis
• Retard the anagen stage from entering the catagen stage [26]

• C57BL/6J mice were used to investigate hair growth promotion activity of PMR and Polygonum multiflorum Radix Preparata (PMRP)
• Hair length, hair covered skin ratio, the number of follicles, and hair color
• Regulating molecules were tested:
• Fibroblast growth factor (FGF-7)
• Sonic Hedgehog (SHH)
• ß-catenin
• Insulin-like growth factor-1 (IGF-1)
• Hepatocyte growth factor (HGF) [26]
• Oral PMR groups had higher hair covered skin ratio (100 ± 0.00%) than oral PMRP groups (48%~88%).
• Topical usage of PMRP had about 90% hair covered skin ratio
• Both oral administration of PMR and topically given PMRP showed hair growth promotion activities
• PMR was considered to be more suitable for oral administration
• PMRP showed greater effects in external use [26]

Prokrvení skalpu

• řešit hypotenzi, anemii
• Mechanicky uvolňovat fascie, svalový hepertonus šíje
• Podpora prokrvení koncových kapilár
• Např. i ginkgo biloba aj.

Proteiny ve stravě

Red ginseng

• A 70% methanol extract
• Steamed and dried roots of Panax ginseng C. A. Meyer, a kind of Ginseng Radix
• In a hair growth promoting assay superior activity to that of white ginseng
• Peeled and dried root of P. ginseng, another kind of Ginseng Radix [19]
• Partially attributable to the ginseng saponin components mentioned above [19]

Rosemary oil

Rumex japonicus Houtt. Extract

• Traditionally used as a medicinal plant to treat patients suffering from skin disease in Korea
• Using human dermal papilla cells (DPCs), HaCaT cells, and C57BL/6 mice model
• Induced antiapoptotic and proliferative effects on DPCs and HaCaT cells
• By increasing Bcl-2/Bax ratio
• Activating cellular proliferation-related proteins
• ERK
• Akt [28]
• Increased ß-catenin
• Via the inhibition of GSK-3beta In C57BL/6 mice model
• Promoted the anagen induction
• And maintained its period [28]
• Upregulated Ki-67 and ß-catenin expressions
• Reinforcement of hair cell proliferation [28]

• Contains a large number of
• Anthraquinones
• Oxanthrones
• Flavones
• Several reports demonstrate
• Antibacterial
• Anti-inflammatory
• Antioxidant effects in skin disease
• Inhibitory effect of atopic dermatitis [28]

Šamponu v kostce proti vypadávání vlasů, 115 g:

• Sodium Coco Sulfate (tenzidy z kokosového oleje)
• Sodium Cocoyl Isethionate (tenzidy z kokosového oleje)
• Coco Glucoside (tenzidy z kokosu a glukózy)
• Glycerin (zvlhčující látka)
• Ricinus Communis (Castor) Seed Oil (ricinový olej)
• Behentrimonium Methosulfate (změkčovadlo)
• Panthenol (provitamin B5)
• Urtica Dioica (Nettle) Leaf Extract (extrakt z kopřivy dvoudomé)
• Rosmarinus Officinalis (Rosemary) Leaf Extract (extrakt z rozmarýnu lékařského)
• Salvia Officinalis (Sage) Leaf Extract (extrakt ze šalvěje lékařské)
• Chamomilla Recutita (Matricaria) Flower Extract (extrakt z heřmánku pravého)
• Citrus Aurantium Dulcis (Orange) Peel Extract (extrakt z pomerančové kůry)
• Citric Acid (kyselina citronová)
• Parfum (parfemace)
• Limonene (vonná látka)
• Linalool (vonná látka)
• Geraniol (vonná látka)
• Coumarin (vonná látka)

CAVE:

• Sodium Coco Sulfate:
• Jedná se o silnou mycí látku, která může vlasy zbavit přirozených olejů a oslabit je, čímž je náchylnější k vypadávání.
• Sodium Cocoyl Isethionate:
• I když je tato látka obecně jemnější než Sodium Coco Sulfate, stále může u citlivých osob způsobovat podráždění pokožky hlavy a vést k vypadávání vlasů.
• Parfum:
• Parfemace a vonné látky v šamponu mohou u citlivých osob vyvolat alergické reakce a podráždění pokožky hlavy, které může vést k vypadávání vlasů.

Složení Šamponu Fitocosmetic 270 ml

• Stimulace růstu vlasů

Hlavní složky:

• Voda: Tvoří základ šamponu.
• Sodium Laureth Sulfate: Čisticí složka, která pění a odstraňuje nečistoty z vlasů.
• Cocamidopropyl Betaine: Čisticí složka, která pomáhá pěnit šampon a zjemňuje vlasy.
• Extrakt z pivovarských kvasnic: Má stimulační účinky a může podpořit růst vlasů.
• Extrakt z chmelu: Má antibakteriální a protizánětlivé vlastnosti, které mohou pomoci zklidnit pokožku hlavy.
• Extrakt ze sladu: Obsahuje vitamíny a minerály, které mohou vyživovat vlasy a pokožku hlavy.
• Další složky:
• Parfemace: Vůně šamponu.
• Barviva: Dodávají šamponu barvu.
• Konzervační látky: Chrání šampon před zkažením.

Spironolactone

• Aldosterone receptor blocker
• Reduces enzyme activity in the biosynthesis of testosterone [25]
• Clinical study of 60 female patients with AGA, topical spironolactone 1%
• Effective in promoting hair growth without hypotonia or hormonal disorders reported [25]
• High incidence of feminizing side effects and are better tolerated in female androgenic hair loss [26]

Sulfotransferase activities

Oils from thyme

Tretinoin

• Topical all-trans-retinoic acid
• Alone and in combination with 0.5% minoxidil
• Tested for the promotion of hair growth in 56 subjects with androgenetic alopecia
• After 1 year topical tretinoin + 0.5% minoxidil
• Terminal hair regrowth in 66% of the subjects studied [17]
• Tretinoin
• Stimulate some hair regrowth in approximately 58% of the subjects studied
• Promote and regulate cell proliferation and differentiation in the epithelium
• May promote vascular proliferation
• Important for hair growth promotion [17]

Vinec

Vitamín C

• Důl. pro absorpci železa v GIT
• Důl. pro stavbu kolagenu

Vitamíny řady B

• Foods containing high amounts of B-complex vitamins may help prevent hair loss [24]

Železo

Zinek

Ziziphus jujuba extract

• Found to promote hair growth
• Antioxidant capacity as the contributing factor [27]