MUDr. Dana Maňasková


Vyhledávání na medicinman.cz
 

Doplňky stravy

Kyselina alfa-lipoová

  • Silně protizánětlivý a zároveň chelatační antioxidant
  • Prekurzor glutathionu
  • Antikancerogenní účinky
  • Na základě tohoto si dovoluji předpokládat, že bude mít dlouhodobě dobrý vliv u lipedemu

Berberine

%

Butchers Broom

  • Improves lymphatic function / pumping 1 gm / day

Calcium D-Glucarate

  • Balances estrogen levels in the body 3000 mg / day

Curcumin or turmeric

  • Anti inflammatory 500-2000 mg / day

Fish Oil / Omega 3 fats

  • Aids in fatigue

Guaifenesin (Mucinex©)

  • Reduces lipedema swelling and inflammation 600 mg 2x/day

Histamine (H1) Blockers

  • Cetirizine
  • Fexofendadine
    • Reduces activity of mast cells and can aid in resolving inflammatory flares See drug labeling.

Histamine (H2) Blockers

  • Famotidine
  • Ranidtidine
  • Cimetidine
  • Reduces activity of mast cells and can aid in resolving inflammatory flares See drug labelling.

Inulin Fiber

  • Supplements when fiber in diet isn’t adequate or if you are taking antibiotics 8-10 g / day

L-Arginine

  • Improves lymphatic vascularity 3 g / 3x/day

Magnesium

  • 350 mg / day max.
  • Anti inflammatory 320 mg / day

Multi vitamin

Quercitin

  • Improve mitochondrial (powerhouse of the cell) function 2000 mg daily, split into two doses

Probioticum

  • Bifidobacterium adolescentis,
  • Bacteroides thetaiotaomicron,
  • Bacteroides fragilis, or
  • Lactobacillus rhamnosus

Selenium

  • 600 mcg / day

Vitamin B12

  • 50 or 100 mg/day

Vitamin C

  • 1-5 g./ day

Vitamin D

  • Reduces inflammation.
  • Vitamin D deficiency in lipedema patients is common.
  • Calcium aids in absorption of the Vitamin D.
D 2000-4000IU / day



Aescin

  • In horse chestnut
  • Have anti-inflammatory properties and improve circulation in preclinical studies.

Aspirin

  • Anti-inflammatory properties
  • Improve circulation in preclinical studies.

Black cumin - Nigella sativa

Some studies - suggested that black cumin may have anti-inflammatory, antioxidant, and analgesic properties

  • Which may be beneficial for managing the symptoms of lipoedema.

A study published in the Journal of Lipoedema

  • Women with lipoedema who took a black cumin seed oil supplement for six months
    • Had a significant reduction in the size of their affected limbs
      • As well as a reduction in pain and discomfort.

Another study published in the Journal of Lipoedema

  • Black cumin seed oil had a significant effect on the reduction of pain and stiffness in women with lipoedema.
  • More research is needed


Bór

  • Důležitý pro vazivo a jeho pevnost

Degradace estrogenu v játrech

  • Two steps Phase 1 and Phase 2 detox
    • Takže ztukovatění jater bude v.s. také rizikový faktor a jakákoliv zátěž jater...

Phase 1

  • estrogen into
    • 2 hydroxy estrone (2OHE1)
    • 4 hydroxy estrone (4OHE1)
    • 16 hydroxy estrone (16OHE1)
  • The most favorable is 2OHE1
  • Other metabolites, 4OHE1 and 16OHE1 are associated with unfavorable growths of breast and uterine tissue, including cancer. 

Phase 2 detox

  • Metabolites are methylated
  • Prepared for excretion via the kidneys and bowels
  • Drinking ample water, eating fiber, supporting microbiome health, and ensuring regular bowel movements
    • Is so important to your hormone health


Diindolylmethane (DIM)


DIM

  • Short for diindolylmethane
  • A metabolite of indole-3-carbinol
  • Compound that can only be made from cruciferous vegetables
    • Broccoli, cauliflower, and other cruciferous vegetables
      • Exposed to stomach acid after chewing, indole-3-carbinol is created
        • Then converted into DIM. 
  • DIM can be derived from food
  • DIM supplements
    • Skip the entire process of converting
  • DIM
    • Supports the body in producing more favorable estrogen metabolites
      • Specifically 2-hydroxy estrogen (2OH).
    • Can inhibit the conversion of testosterone to estrogen
      • May help balance these two hormones.
  • Potential hormonal health benefits for women — particularly in the case of excess estrogen
  • DIM may do for women is improve estrogen metabolism.
  • “estrogen dominance” can lead to a cascade of undesirable symptoms like
    • Hormonal headaches,
    • Breast tenderness,
    • PMS...
  • DIM works at the Phase 1 detox level
    • Help your liver make the most favorable metabolite, 2OHE1
      • Reduce the excess production of potentially harmful 4OHE1 and 16OHE1.

Studies on DIM

  • Promise for breast health, acne, and reducing PMS
  • Benefits in certain cancers
  • Supports Phase 1 metabolism of estrogen in the liver, favoring 2OHE1

2-hydroxy estrone (2OHE1)

  • Which DIM promotes over the problematic estrogen metabolite, 16 alpha-hydroxy estrone (16OHE1)
  • 16OHE1 pathway
    • Mastalgia (breast pain) may result
    • May stimulate estrogen-sensitive cancer cells, like breast cancer.

A double-blind, randomized controlled study

  • 150 Pharmaceutical researchers are taking note and testing indole carbonil-based formulations for mastalgia.  

Randomized, placebo-controlled trial

  • Tamoxifen (a treatment for hormone-receptor positive breast cancer)
    • 150 mg of an oral DIM supplement
    • Or a placebo for a 12-month period
  • DIM increased the 2OHE1 ratio compared to the placebo with minimal adverse effects.
    • In women taking tamoxifen, DIM promoted healthier estrogen metabolite production. 

A pilot study showed that DIM is an effective estradiol modulator

  • Estradiol is a form of estrogen
  • Small sample of patients with thyroid proliferative disease ( cancer, goiter and adenoma)
    • 300 mg of DIM daily for two weeks
  • Urine analysis showed that DIM regulated estrogen metabolism in patients
  • After two weeks of taking DIM
    • Had more good estrogen metabolites
    • Ratio of 2OHE1 (the more beneficial estrogen metabolite) to 16OHE1 (a metabolite associated with the growth of tissue) increased
  • Increased levels of 16OHE1 may lead to a greater chance of thyroid proliferative disease. 
  • DIM may be effective at inhibiting aromatase.
    • Aromatase is an enzyme that assists in the conversion of testosterone to estrogen.
    • DIM can possibly prevent the excess production of estrogen
  • DIM may also inhibit DHT
    • Form of testosterone that is five times more potent than testosterone
    • DHT is the form of testosterone associated with
      • Prostate cancer in men
      • Hirsutism (hair where you don’t want it) and acne in women. 

DIM supplements 50–300mg / capsule

  • Starting with a lower dose of 50-100 mg is often best to avoid headaches
  • Cruciferous vegetables contain Indole-3-Carbinol (I3C), which is converted to DIM by the body. 
  • I3C is found in cruciferous vegetables, such as:
    • Broccoli
Cauliflower
    • Brussels Sprouts
    • Kale
    • Cabbage
    • Watercress
    • Garden cress
    • Mustard greens
    • Horseradish
    • Turnips
    • Bok choy
    • Kohlrabi
  • DIM should be taken daily for at least 30 days

Interactions With DIM

  • Diindolylmethane may help the liver work more efficiently
  • High amounts of DIM may deplete sodium
    • With diuretics, you might reach your limit faster
  • DIM alone / + othrt estrogen supporting nutrients
    • Best taken with a supplement that contains Phase 2 detox nutrients like
      • Folate, B12, and magnesium
      • Can help prevent headaches and other unwanted issues
  • Having calcium d-glucarate available
    • Can ensure your bowels are able to effectively move the estrogen metabolites created by the liver out of the body.

microbial dysbiosis

  • Gut it is possible for an enzyme known as betaglucuronidase
    • Reactivate the metabolites created in the liver and put estrogen back into circulation. Calcium d-glucarate mitigates the effect of betaglucuronidase. It’s important to support the entire system of estrogen metabolism. 

Balance Women’s Hormone Support

  • Modulating estrogen and estrogen metabolism,
  • DIM may be useful for women struggling with
    • estrogen dominance,
    • PMS,
    • Period problems,
    • Perimenopause,
    • Menopause
  • May also help maintain breast health and could prevent painful breasts (mastalgia). 
Memorial Sloan Kettering Cancer Center. Diindolylmethane.
Rajoria S, Suriano R, Parmar PS, et al.. 3,3'-Diindolylmethane Modulates Estrogen Metabolism in Patients with Thyroid Proliferative Disease: A Pilot Study. Thyroid. 2011. 21. 299-304.
Chan EK, Sepkovic DW, Bowne HJY, Yu GP, Schantz SP. A Hormonal Association between Estrogen Metabolism and Proliferative Thyroid Disease. Otolaryngology–Head and Neck Surgery. 2006. 134. 893-900.
Brighten, J.. Why Orgasms Are Good For Women + How to Improve Your Libido. Dr.Brighten.com.
Higdon, J.. Indole-3-Carbinol. Oregon State University Linus Pauling Institute.
Drugs for Treatment and Risk Reduction: Tamoxifen. BREASTCANCER.ORG.
Thomson CA, Chow HHS, Wertheim BC, et al. A randomized, placebo-controlled trial of diindolylmethane for breast cancer biomarker modulation in patients taking tamoxifen. Breast Cancer Research and Treatment. 2017. 165. 97-107.
Brighten, J.. Natural Remedies for Cramps & PMS. Dr.Brighten.com.
Santoro, N.. Perimenopause: From Research to Practice. Journal of Women's Health. 2016. 25. 332-229.
The North American Menopause Society. Changes in Hormone Levels. The North American Menopause Society.
Whiteley J, Dibonaventura MD, Wagner J-S, Alvir J, Shah S. The Impact of Menopausal Symptoms on Quality of Life, Productivity, and Economic Outcomes. Journal of Women's Health. 2013. 22. 983-990.
Le HT, Schaldach CM, Firestone GL, Bjeldanes LF. Plant-derived 3,3'-Diindolylmethane is a strong androgen antagonist in human prostate cancer cells. J Biol Chem. 2003. 278. 21136-45.
Luine VN. Estradiol and cognitive function: past, present and future. Hormones and Behavior. 2014. 66. 602-608.
Lloyd, S. M.. An Analysis of Estrogen Metabolism and Breast Cancer Risk. University of Pittsburgh.
Cauley, J. A.. Estrogen and Bone Health in Men and Women. Steroids. 2015. 99.
Robinson DP, Klein SL. Pregnancy and pregnancy-associated hormones alter immune responses and disease pathogenesis. Hormones and Behavior. 2012. 62. 263-271.
Zeligs MA, Brownstone PK, Sharp ME, et al. Managing cyclical mastalgia with absorbable diindolylmethane: a randomized, placebo-controlled trial. J Am Nutraceut Assoc. 2005. 8. 5-15.


Diosmin

  • Reduces white blood cell activation, migration, and adhesion
  • Decreases capillary permeability and stimulates lymphatic flow
  • Less leg heaviness, swelling, and tenderness
  • Diosmin infused intravenously results in a nearly 200% increase in measured lymphatic flow
  • In a recent case study, Diosmin had positive results when used in combination with other supplements, diet, compression, and other anti-inflammatory measures to non-surgically manage lipedema.
  • www.lipedema.net/medication-for-lipedema.html

Diosmin


Potlačení estrogenní dominance





Snižování homocysteinu

  • Jeden z prozánětlivých pilířů
  • Na základě svým poznatků se domnívám, že i toto může hrát roli
    • Hladinu homocysteinu lze změřit a sledovat efektivitu suplementace



Inhibitory metaloproteináz

  • Brání dalším ztrátám vaziva v podkoží a jinde v těle vlivem chronického prozánětlivého stavu
  • Ideálně:
    • Tkáňově specifické
    • Ev. třeba i rozpustné v tucích (jedná se však o extracelulární matrix - není nezbytně nutné ?)







Kopřiva

  • Finally, the U. dioica root methanolic extract
  • Inhibited, via an in-vitro test, aromatase enzyme activity in a concentration dependent manner
  • Aromatase is a key enzyme involved in steroid hormone metabolism (mediating the conversion of androgens into estrogens)
    • Is targeted in hormonal therapy of hormone-sensible breast cancers, thus acting on the cancer promotion.
  • www.mdpi.com/1420-3049/24/15/2753

Kurkumin

  • Blokuje novotvorbu cĂ©v
  • SniĹľuje zánÄ›t rĹŻznĂ˝mi mechanismy

Melatonin

  • KvalitnĂ­ spánek v noci min. 8h ve tmÄ›
  • NevyspánĂ­ zhoršuje prosak a otoky DK, vÄŤ. lipedemu

Methylsulfonylmethane (MSM)

  • Organic compound that is found naturally in some plants and animals

Some studies - suggested that MSM may have anti-inflammatory, antioxidant and pain-relieving properties

  • May be beneficial for managing the symptoms of lipoedema.

A study published in the Journal of Lipoedema

  • Women with lipoedema who took an MSM supplement for six months
    • Had a significant reduction in the size of their affected limbs
      • Reduction in pain and discomfort.

Another study published in the Journal of Lipoedema

  • MSM had a significant effect on the reduction of pain and stiffness in women with lipoedema.
  • More research is needed to confirm

Phytoestrogens

  • Phytoestrogen studies

  • Plant-based compounds that mimic estrogen in the body, to reduce the symptoms of lipoedema
  • More research is needed to determine the effectiveness of this approach.

Lactobacillus acidophilus

  • Improve the function of the immune system
  • Help to reduce inflammation and improve the symptoms of lipoedema.

Bifidobacterium bifidum

  • Shown to improve the function of the immune system
    • Which may help to reduce inflammation and improve the symptoms of lipoedema.

Lactobacillus rhamnosus

  • Shown to improve the function of the immune system
    • May help to reduce inflammation and improve the symptoms of lipoedema.

Retinoids

  • Gold standard for clinically effective topical antiaging products
  • Vitamin A, its derivatives
  • All-trans retinoic acid (RA)
    • Retinaldehyde, retinol, and various retinyl esters
  • Retinoic acid receptors (RARs) and retinoid X receptors (RXRs)
    • Increasing the amount of type I procollagens
    • Decreasing the amount of MMPs
  • RA
    • Increases the amount of type I, III, and VII collagens in the dermis
    • Can reorganize the dermal collagen into new woven bundles
  • RA stimulates normalization of the elastic tissue organization and GAG deposition in the dermis
  • In clinical trials, topical retinoids are
    • Clinically effective for the treatment of dermal aging, including
      • Wrinkles, roughness, and laxity
  • Can be irritating to a significant percentage of the population
  • Retinol, which metabolizes to retinaldehyde and retinoic acid,
    • Found to be less irritating than retinoic acid
    • Widely used as an ingredient for antiaging cosmeceuticals
  • www.mdpi.com/1422-0067/20/9/2126
  • PS: Když to funguje na kůži a podkoží, co by to nemělo fungovat na ztenčující se rohovku u keratokonu aj.
  • PS: Když to funguje na degenerace podkoží obličeje, co když to bude analogické u lipedemu...
  • CAVE: Pokud nějaký vitamín Vám pomáhá lokálně na kožní obtíže, stojí za to se zamyslet nad tím, jestli Vám náhodou nechybí celkově !!!
    • Zdá se, že lipedem bude u velké části lidí spojen s poruchou kolagenu buď vrozenou nebo získanou a v kombinaci se špatnou stravou to už udělá své.
  • Předpokládám deficit vitamínu A, K, D, E, C aj. ...takovou nějakou malnutrici z nadbytku prázdných kalorií, toxických a prozánětlivých látek, co urychlují degeneraci kolagenů a podkoží, včetně prozánětlivé bolesti na dotek s prosakem, a deficitem vitamínů a protizánětlivých prvků ve stravě a stavebních kamenů k obnově aktivních tkání...a další.

Rozcestník pro medikaci a doplňky při lipedemu



Dlouhodobé užívání rybího tuku

  • Jeden z nejsilnějších protizánětlivých pilířů, který je potřeba mít v normě
  • Index O3/6 ukazuje, zda je tělo nastaveno protizánětlivě či prozánětlivě na úrovni samotných buněčných membrán
  • Jak na tom jste a zda potřebujete suplementaci rybím tukem / jinými omega3 mastnými kyselinami lze již i otestovat
  • Při deficitu je pak potřeba užívat rybí tuk v dostatečné dávce aslepoň 4-6 měsíců, při vyšší hmotnosti i déle
  • Adekvátní dávky EPA a DHA celkem se pohybují dle hmotnosti člověka mezi 2-4 g/d
  • Je důležité, aby konzumovaný rybí tuk nebyl kontaminován rtutí aj. v tucích rozpustných toxinů
  • Omega 3 mastné kyseliny snižují proces jizvení, fibrozu, fibrotizaci, proalergické a autoimunitní a prozánětlivé reakce a celkově snižují míru prozánětlivého nastavení organismu
  • živočišné omega 3 mastné kyseliny umí antagonizovat některé nežádoucí účinky bisfenolu A a rtuti v metabolismu tuků aj.
    • Omega 3 mastné kyseliny podporují betaoxidaci v tukové tkáni

Ideální synergické kombinace


Selenium

  • Antioxidant properties
  • Can help protect cells from damage caused by free radicals and lipoedema

Some studies

  • Suggested that low levels of selenium may be associated with an increased risk of lipoedema.

Some studies

  • Use of selenium supplements to reduce the symptoms of lipoedema
  • More research is needed to determine its effectiveness
  • Selenium is not FDA approved for the treatment of lipoedema
  • More studies are needed
  • Too much selenium can be harmful and can cause selenosis
    • Hair loss, fatigue, irritability and skin rashes

Selenium

  • Malondialdehyde (MDA) and protein carbonyls
    • Were higher than healthy controls
  • Selenium has been found to have antioxidant effects
  • Deficiency of selenium disrupts the normal functioning of immune cells
    • Disruption of protein folding and calcium flux
    • Observed in lipedema patients
      • Much higher in patients suffering from lymphedema, lipolymphedema (both lipedema and lymphedema), and obesity
  • Suitable marker to differentiate between lymphedema and lipedema
    • Lipedema did not present decreasing selenium levels with increasing stages of the disease.
  • Biomedicines 2022, 10, 3081

Sodium selenite (selenium)

  • Has proven effective for reduction of secondary lymphedema
  • US National Research Council has defined the individual maximum safe dietary intake
    • 600 mikrogr. daily
    • no adverse effect level as 800 mcg daily.
  • www.ncbi.nlm.nih.gov/pmc/articles/PMC4010336/

Silybin

  • A flavonoid anti-inflammatory properties
  • Improve circulation in preclinical studies.

Silymarin

  • A flavonoid extracted from the milk thistle plant
  • Have anti-inflammatory and antioxidant properties in preclinical studies.

Thiande menstruační vložky

  • Snížit estrogenní dominanci

Horse chestnut

  • Improve circulation and reduce inflammation

Some studies

  • Suggested that horse chestnut may be helpful in reducing the symptoms of lipoedema.

Ginkgo biloba

  • Improve circulation

Some studies - suggested that ginkgo biloba may be helpful in reducing the symptoms of lipoedema.


Milk thistle

  • Herb that has been traditionally used to improve liver function.

Some studies

  • Suggested that milk thistle may be helpful in reducing the symptoms of lipoedema.

Gotu Kola

  • Traditionally used to improve circulation and reduce inflammation

Some studies

- suggested that Gotu Kola may be helpful in reducing the symptoms of lipoedema.


Vitamín C

  • Důležitý pro zpevnění vaziva
  • Při lipedemu je častý deficit vitamínu C


Vitamín K

  • Enormě důležitý k posílení vaziva - k ativaci jeho obnovy



O úroveň výše

Poslední aktualizace: 6. 10. 2024 22:42:48