MUDr. Dana Maňasková


Vyhledávání na medicinman.cz
 

Hepatoprotektiva

Hepatoprotektivně působící látky

  • Nearly 160 phytoconstituents from 101 plants [2]
  • India
    • More than 87 plants
    • 33 patented formulations [2]

Herbs with potentially hepatoprotective constituents

Abutilon indicum - Monkeybush - Indian Lanternflower - Indian Mallow

  • Significant hepatoprotective activity
  • Reducing carbontetrachloride and paracetamolinduced change in bio-chemical parametersthat [4]
  • May interfere with free-radical formation, which may conclude in hepatoprotective action [4]
  • Inhibitory effects of drug on cytochrome P450 or/andpromotion of its glucuronidation [4]

Aegle marmelos - Bael - Bilva - Bengal quince - stone apple- wood apple - Bilvapatre - Shivaphala - Bel [2]

  • Protekce při alcohol-induced liver injury in rats [2]

Acanthus ilicifolius - Holly-leaved acanthus - Sea Holly - Holy Mangrove

  • Effective against CCl4 induced liver injury, in vivo [3]
Almond oil [1]

Amomum xanthioides (Zingiberaceae) - Amomum villosum Lour. var. xanthioides (Wall. ex Baker) - Hamakaenang - Reo-yai - Suc sa mat - Kardemon - black cardamom seed - black cardamom - brown cardamom - kravan - Java cardamom - Bengal cardamom - Siamese cardamom - white cardamom - red cardamom [1]

  • Potlačení zánětu žaludku vlivem alkoholu, HCl, Helikobakterem pylori

Andrographis paniculata - King of Bitters - Kalmegh - Chuan Xin Lian - Green chirayta, creat, andrographis, India echinacea - Kirayat - Hempedu Bumi - Měkýn latnatý [4]

  • Leaves contain andrographolide, most active component [4]
  • Alcoholic extract of the leaves effective in prevention of liver damage
  • Liver protective effects:
    • Enhancing activity of antioxidant enzymes
      • Superoxide dismutase, catalase
      • Glutathione peroxidase
      • Glutathione reductase
    • Decreasing the activity of lipid peroxidase [4]
  • V ČR např. v kombinaci v: Livlon-N

Annona squamosa - láhevník šupinatý - anona šupinatá [2]

  • Protective effect in isoniazid + rifampicin-induced hepatotoxicity in albino Wistar rats
  • Protective in diethylnitrosamine induced hepatotoxicity [2]

Antrodia camphorata - Niuchangchih - Outkovka kafrová [18]

  • Basidiomycete endemic to Taiwan [18]
  • Houba rostoucí na Tchaj-wanu pod kůrou skořicovníku Kanehirova (Cinnamomum kanehirai Hayata)
  • Predominantly polysaccharides, triterpenoids, steroids, benzenoids and maleic/succinic acid derivatives [18]
  • Hepatoprotective, antihypertensive, anti-hyperlipidemic, immuno-modulatory, anticancer, anti-inflammatory and antioxidant activities [18]
  • Fruiting bodies and fermented products
    • Preventing ethanol-, CCl(4)- and cytokine-induced liver injury ::18:
    • Inhibiting the hepatitis B virus ::18:
    • Ameliorating fatty liver and liver fibrosis ::18:
    • Inhibiting liver cancer cells ::18:

Apiaceous vegetable

  • carrots, parsnips, celery, parsley, etc.
  • Inhibit human cytochrome P-450 1A2 (hCYP1A2) activity and hCYP1A2-mediated mutagenicity of aflatoxin B1 [35]
  • Potent inhibitors of hCYP1A2-mediated MROD activity in yeast microsomes:
    • Psoralen
    • 5-methoxypsoralen (5-MOP)
    • 8-methoxypsoralen (8-MOP) [35]
    • apigenin
  • Modest hCYP1A2 inhibitor
    • Quercetin [35]

Arctium lappa - greater burdock - gobo - edible burdock - lappa - beggar's buttons - Lopuch větší - bodlák [1]

Asparagus officinalis L. – chřest lékařský - asparágus lekársky - hromové kořenie, hromové koření, chřest obecná, chřest lékařský, chřest obecný

  • Chřest bývá pěstován v zahradách, používá jako dekorativní prvek k řezaným květinám do kytic [20]
  • Také jako zelenina – zužitkovávají se výhonky [20]
  • Amino acid and inorganic mineral contents were found to be much higher in the leaves than the shoots [21]
  • Cellular toxicities induced by treatment with hydrogen peroxide, ethanol, or tetrachloride carbon were also significantly alleviated in response to treatment with the extracts of A. officinalis leaves and shoots. [21]
  • Alcohol dehydrogenase and aldehyde dehydrogenase were upregulated by more than 2-fold in response to treatment with the leaf- and shoot extracts [21]
  • Alleviation of alcohol hangover [21]
  • Protection of liver cells against toxic insults [21]

Astragalus membranaceus - Astragalus propinquus - membranous milk-vetch root - kozinec blanitý - Huang Qi [1]

  • Taiwan
  • The extract from the roots of P. lactiflora and A. membranaceus demonstrated better hepatoprotective activity than the herbs used individually [1]

Boerhavia diffusa - Punarnava - Boerhavia repens - hirsuta - procumbens - berhavie rozkladitá - red spiderling - spreading hogweed - tarvine Kotvičník zemní [4]

  • Effectiveness in cases of oedema and ascites in early cirrhosis of the liver and chronic peritonitis. [4]
  • Chloroform and methanolic extracts of the roots and aerial parts are hepatoprotective against carbon tetrachloride [4]
  • One of the major ingredient offered significant protection against
    • Decrease in haemoglobin percentage R.B.C.
    • And W.B.C counts
    • Various liver microsomal enzymes [4]

Borreria articularis (L.F) F.N.Willams:(Rubiaceae) - B. hispida (L.) Schum. - Spermacoce hispida L.

  • Carbontetrachloride (CCl4) intoxication
  • Dose of 250 and 500 mg/kg of plant b.w.p.o.had reduced the AST, ALT, ALP and TB levels and the effects were compared with standard drug (Silymarin 100mg/kg b.w.p.o). [4]

Brassica - Crucifera - Cruciferous vegetables [1]

  • Brokolice
  • Kapusta hlávková, růžičková
  • Kedlubna
  • Květák
  • Zelí čínské, hlávkové, bílé, červené ap.
  • Dithiolethiones
    • Appear to inhibit carcinogenesis [26]
  • Oltipraz
    • Potent inducer of Phase II detoxification enzymes [26]
      • Glutathione-S-transferase (GST)
        • Levels of hepatic aflatoxin-DNA adducts, urinary aflatoxin-N7-guanine, and serum aflatoxin-albumin adducts decreased when biliary elimination of aflatoxin-glutathione conjugants increased = chemopreventive effect [26]
        • Dietary concentrations of oltipraz produce marked inhibition of aflatoxin B1-induced hepatic tumorigenesis in rats [26]
    • Found to inhibit chemically induced carcinogenesis in bladder, colon, breast, stomach, and skin cancer models [26]
    • Oltipraz over 1-3 days for the treatment of schistosomiasis [26]

Cassia roxburghii - Ceylon senna - red cassia [2]

  • Methanolic extract reversed the toxicity of ethanol-CCl4 combination in dose dependent manner [2]

Cichorium intybus - Chicory - Čekanka [1] [2] [4]

  • Protektivní u thioacetamide-induced hepatotoxicity in rat [2]
    • Due to the presence of flavonoids and their antioxidant effects [2]
    • Free radical scavenging ability [2]
  • Alcoholic extract of the Cichorium intybus effective against chlorpromazine-induced hepatic damage in adult albinorats [4]
  • Protect the CCl4 and paracetamol intoxicated liver in rats
  • Significant anti-hepatotoxic properties
  • Ethanol extract of Cichorium intybus 300 mg/kg showed
    • Significant liver protective effects [4]

Codonopsis lanceolata - bonnet bellflower - deodeok kimchi - deodeok jeon - deodeok gui - deodeok saengchae - changui [22]

  • Root water extract attenuates the development of alcoholic fatty liver in rats
  • Appears to be protective against alcoholic fatty liver through the regulation of SREBP-1c, LXRalpha, HMGR, and LDLR genes and by the phosphorylation of AMPKalpha and ACC, which are implicated in lipid metabolism [22]

Curcuma longa - Turmeric - Indian saffron - kurkuma [1]

Cajanus indicus - Kajan indický (luštěnina) [1]

  • Rostlina, která má jako plod: Pigeon peas

Chamomile recutita v.s. synonyma: Matricaria chamomilla var. recutita [2] Matricaria chamomilla = Matricaria recutita - Heřmánek pravý - heřmánek lékařský

  • Ethanolic extract reversal effects in paracetamol hepatotoxicity [2]
  • Hepato-protective and/or hepatostimulant [2]

Centella asiatica - Hydrocotyle asiatica L. - Trisanthus cochinchinensis - gotukola - tiger grass - pupečník asijský [1]

Citrus Microcarpa - Citrofortunella microcarpa - Citrofortunella mitis - Citrus fortunella - Citrus mitis - Citrofortunella mitis [4]

  • Bunge fruit peel extract
  • Significant decrease in ALT, AST and AP levels among rats administered with the fruit peel extract [4]

Coccinia grandis Linn (Curcubitaceae) - baby watermelon - little gourd - gentleman's toes - tindora - gherkin - Bryonia grandis L. - Coccinia indica Wight & Arn. - Coccinia cordifolia - ivy gourd [2]

  • In CCl4- induced hepatotoxicity in rats [2]
  • Alcoholic extract significantly decreased AST, ALT and ALP and bilirubin [2]
    • Comparable to that of silymarin hepato-protective effect [2]

Eclipta alba (Hassk) - Bhringaraja - Compositae - Eclipta prostrata (L.) - False Daisy - yerba de tago - bhringraj [4] [1]

Eisenia bicyclis - Ecklonia bicyclis - sea oak - arame tengeri alga - vrsta alge - Kjellman - Setchell

  • Patří mezi hnědé řasy, které jsou zvlášť bohaté na jód a vápník [29]
  • Inhabits the middle Pacific coast around Korea and Japan [29]
    • Hlavně u pobřeží japonského ostrova Izu [29]
  • Nasládlá chuť - obsah manitu (přírodní cukr) ve většině hnědých řas [29]
  • 100 g ARAME obsahuje: 1170 mg vápníku, 12 mg železa, 300 mg jódu, 3860 mg draslíku, 3860mg draslíku, 150g fosforu, 2,3 mg niacinu, 7,1g vlákniny, 12,1g bílkovin, 44,7g sacharidů, 50 j. vitamínu A, vitamíny B1 a B2 [29]
  • Silně antioxidačně působící složky extraktu [30]
  • Potential candidates for natural hepatoprotective agents [30]

Foeniculum vulgare Mill. (Umbelliferae) - Fennel - Fenykl [27] [4]

  • Volatile components of fennel seed extracts by chromatographic analysis include:
    • Transanethole
    • Fenchone
    • Methylchavicol
    • Limonene
    • Alfa-pinene
    • Camphene
    • Beta-pinene
    • Beta-myrcene
    • Alfa-phellandrene
    • 3-carene
    • Camphor
    • Cisanethole [4]
  • Hepatoprotective activity of Foeniculum vulgare essential oil
    • Carbon tetrachloride-induced liver fibrosis model in rats
      • Essential oil inhibited the hepatotoxicity [4]
      • Decreased levels of serum ALP, AST, ALP, bilirubin [4]
  • Fennel seed methanolic extract (FSME)
    • Hepatoprotective [27]
    • Before irradiation exerted a cytoprotective effect against gamma irradiation
      • Restoration of the MDA level, catalase activity, and GSH content to near-normal levels [27]
    • Remarkable anticancer potential against
      • Breast cancer cell line (MCF7) [27]
      • Liver cancer cell line (Hepg-2) [27]
    • Strong free radical-scavenging activity [27]
    • Improve the oxidative stability of fatty foods during storage [27]

Emblica officinalis - Phyllanthus emblica - Indian gooseberry - Embelic myrobalan - aamla - Graceo - amalika - Embilika lékařská [9] [3]

  • 50% hydroalcoholic extract of the fruits
  • Against antituberculosis (anti-TB) drugs-induced hepatic injury
    • Rifampicin (RIF), isoniazid (INH) and pyrazinamide (PZA)
  • Hepatoprotective activity:
    • Membrane stabilizing [9]
    • Antioxidative [9]
    • CYP 2E1 inhibitory effects [9]
  • vitamin C, amino acids, and minerals [23]
  • phenolic compounds, tannins, phyllembelic acid, phyllembelin, rutin, curcum-inoids, and emblicol [23]
  • In traditional medicine for the treatment of diarrhea, jaundice, and inflammation [23]

Ficus carica - edible fig - běžný fík - Fíkovník smokvoň [2]

  • Methanolic extract of the leaves hepatoprotective activity in CCl4 -induced liver damaged rats [2]

Flacourtia indica - Flacourtia ramontchi - ramontchi - governor's plum - batoko plum - Indian plum - Madagaskarská švestka [2]

  • In paracetamol-induced hepatic necrosis in rat models
    • All extracts were found to reduce serum AST, ALT, ALP [2]
    • Nejlepší efekt:
      • Petroleum ether extract
      • Ethyl acetate extract
        • V.s. inhibition of microsomal drug metabolizing enzymes
    • žádný efekt:
      • Methanol extract

Flickingeria fimbriata [1]

Fumaria officinalis - Fumatory

Ganoderma lucidum - lingzhi mushroom - reishi mushroom - pinyin - língzhi - linh chi - lesklokorka lesklá

Garcinia kola - Garcinia kola Heckel - bitter kola [8]

  • Widely consumed in some West African countries
  • Kolaviron, a Garcinia biflavonoid from the seeds [8]
    • Against oxidative damage to molecular targets ex-vivo and in vitro [8]
    • Kolaviron exhibits protective effects against oxidative damage to molecular targets via scavenging of free radicals and iron binding [8]
    • Kolaviron may therefore be relevant in the chemoprevention of oxidant-induced genotoxicity and possibly human carcinogenesis [8]

Glycyrrhiza glabra - Liquorice - cultivated licorice - Lékořice lysá [1] [2]

  • Hepatoprotective
  • Capable of inducing an endogenous interferon [2]

Ginkgo biloba extracts

  • Effective against CCl4 induced liver injury, in vivo [3]

Guizhi Fuling Wan [1]

  • Chinese traditional prescriptions

Halenia elliptica - Spurred Gentian - Swertia peloris [1]

  • A medicinal herb of Tibetan folk medicine used to treat hepatitis [1]

Hemidesmus indicus - Indian Sarsaparilla - Anantamul - Sariva - utpalsariva - gopavalli - sugandhi - gopilamum [3]

Hizikia fusiformis - Hijiki Seaweed [15]

  • Glycoprotein from the brown alga Hizikia fusiformis (HFGP)
  • Could protect against Acetaminophen (AAP)-induced liver injury in vivo and in vitro
    • One of the most commonly abused drugs, may cause fatal liver injury [15]
  • Effects of HFGP on AAP toxicity in rats:
    • Serum glutamic pyruvic transaminase level was restored to the control level
    • Glutathione level was also increased
    • Decreased caspase-3/-9 activity [15]
  • HFGP may inhibit AAP-induced liver injury in Sprague-Dawley rats [15]

Hovenia dulcis - Japanese raisintree - raisin tree - kenpo nashi - chichao li [37]

  • Mice treated with juice or fermented vinegar from Hovenia dulcis peduncles
    • Better profiles of the antioxidant systems
      • Higher glutathione (GSH) content
      • Higher total superoxide dismutase (T-SOD)
      • Higher catalase (CAT)
      • Higher glutathione peroxidase (GSH-Px) activities [37]
    • Better histological observations in liver
    • Juice and fermented vinegar have beneficial effects in reducing the adverse effect of alcohol [37]

Chionanthus virginicus - Fringe tree - old man’s beard

Kalopanax pictus - prickly castor oil tree - Kalopanax pestrý - K. septemlobus [1]

Lepidium sativum - Garden cress - řeřicha setá [2]

  • Methanolic extract in CCl4-induced liver damage in rats
    • Sig-nificant reduction in all biochemical parameters and severe fatty changes in the livers of rats caused by CCl4 were insignificant in the treated group [2]

Morus nigra fruit - Moruše černá [7]

  • Extracts incl. juice inhibited:
    • haemoglobin glycosylation induced by glucose to differing degrees [7]
    • Haemolysis of human erythrocytes induced by hydrogen peroxide [7]
    • Production of malondialdehyde (MDA) during peroxidative damage to plasma membranes of isolated rat hepatocytes by tert-butyl hydroperoxide (tBH) [7]
    • Lipid peroxidation of LDL induced by copper (II) ion [7]
  • Has a protective action against peroxidative damage to biomembranes and biomolecules [7]

Murraya koenigii - Bergera koenigii L. - Chalcas koenigii (L.) Kurz. - curry tree - Curryleaf tree - Sweet nim - Arbre a curry - Karipatta - Mitha nim - Mitha neem patta - Kari list, Karri, Curry, Curry leaf, Karapincha [1]

Nelumbo nucifera - sacred lotus - Lotos indický [24]

Nymphaea stellata - Indický lotos - blue lotus [1]

Ocimum sanctum - Ocimum tenuiflorum - Holy Basil - tulsi - tulasi - warung - aring - kadiring - lamar - Kemangen - bazalka posvátná[1]

Orthosiphon stamineus - Java Tea - Misai Kuching - Listy javánského čaje [2]

  • Methanol extract protektivní in paraceta-mol-induced hepatotoxicity rat model [2]

Paeonia lactiflora - pivoňka čínská - pivoňka bělokvětá (Presl 1846, Dostál 1989) - pivoňka velkokvětá (Mareček 1999) [1]

Pergularia daemia - Trellis-vine [1]

Peumus boldus - Boldo

Picrorhiza Kurroa - Kutki [1] [2]

Phalaenopsis amabilis - Prostechea michuacana (La Llave & Lex.) W.E. Higgins 1997 - Encyclia icthyphylla (Ames) Hoehne 1952 - Encyclia virgata (Lindl.) Schltr. 1914 - Epidendrum amabile L. Linden & Rchb. f. 1855 - Epidendrum ichthyphyllum Ames 1923 - Epidendrum michuacanum La Llave & Lex. 1825 - Epidendrum sphaerobulbon A. Rich & Gal. ? - Epidendrum virgatum Lindl. 1840 - Moon orchid - Lišajovec biely [2]

Picrorhiza scrophulariiflora - Picrorhiza kurroa Royle ex Benth [3]

Phyllanthus amarus - smuteň hořká - Phyllanthus niruri var. amarus - Phyllanthus nanus - Phyllanthus scabrellus [1] [2] [4]

  • Antiviral against hepatitis B and C viruses [2]
  • Hepatoprotective
  • Immunomodulating effects
    • Anti-inflammatory properties [2]
  • Whole dried drugpowder of the plant traditionally used in the treatment of Jaundice
    • Hepatoprotective activity on 107 patients suffering from liverdisease
      • P.o. 3 g: morning - noon - night for 30-45 days [4]
      • Biochemical markers: SGPT, Billirubin, Hb ve dnech: 0, 7, 14, 21, 28, 42
      • Significant:
        • Decrease in SGPT, Billirubin [4]
        • Increase in hemoglobin [4]

Plumbago zeylanica - Olověnec cejlonský [1]

Pueraria lobata (Willd.) Ohwi. (Leguminosae) - Flos Puerariae - Ge Hua - Kudzu root - kuzu - Pueraria montana var. lobata - Kudzu vine [6]

  • Kakkalide is a prodrug of irisolidone in protecting against ethanol-induced lethality and hepatic injury [6]
  • CCl4-induced hepatic injury in albino rats
    • Methanol extracts
      • Dose-dependant reduction in the in vivo peroxidation induced by CCl4 [2]
      • Eliminating the deleterious effects of toxic metabolites of paracetamol [2]
  • V ČR: www.countrylife.cz/kuzu-skrob-kousky-100-g-bio-muso

Rhus coriaria L. - Sicilian sumac - Sumach - Ruj - Koření sumac - Sumah - Škumpa koželužská

  • Sumach hojně vysazován pro svůj dekorativní vzhled. [16]
  • Jako koření se však používají pouze červené bobulovité plody odrůdy coriaria. [16]
    • Pro okyselení se mletý sumach přidává též do některých indických směsí koření ‚curry‘ [16]
  • Odrůdy ostatní, rozšířené hlavně v USA jsou nejen nepoživatelné, ale dokonce prudce jedovaté [16]
  • Staří Řekové používali sumach k výrobě kyseliny tříslové potřebné k vydělávání kůží. Z kůry a listů získávali vosk a červenohnědé barvivo [16]
  • The antioxidant effects of extract are probably due to scavenging which was observed in in vitro experiments [15]
    • Indicated that gallic acid is the active principle of sumach [15]
  • The animal experiments showed that sumach also causes protection in inner organs [15]
  • Supplementation of the drinking water (0.02g/kg per animal) decreased
    • The formation of oxidized DNA bases in colon, liver, lung and lymphocytes [15]
    • Also after gamma-irradiation pronounced effects were seen [15]
  • V ČR:

Salacia reticulata (Hippocrateaceae) - Kotalahimbatu - Marking Nut Tree - Saptarangi [4]

  • Oxidative stress-induced liver injury model in CCl4 treated mice
    • Extracts significantly suppressed:
      • Increase in glutamic oxaloacetic transaminase activities
      • Increase in glutamic pyruvic transaminase activities
      • CCl4 -induced thiobarbituric acid-reactive substance formation
        • Indicates increased lipid peroxidation in the liver
    • Results suggest that the antioxidative activity is involved [4]
  • Salacinol a Cotalanol
    • Alfa-glucosidázové inhibitory (enzymu štěpící ve střevě disacharidy a polysacharidy obsahující glukózu)
    • Zpomalují vstřebávání sacharidů ze střeva
  • Mangiferin
    • Omezuje uvolňování cukru z jater, přispívá ke snížení hladiny krevního cukru

Sargassum polycystum - Sargassum polycystum C.Agardh, 1824 [2]

  • Type of brown alga
  • Protective effect of ethanol extract in D-galactosamine-induced hepatitis in rats [2]

Saururus chinensis - Saururopsis chinensis (Loureiro) Turczaninow - S. loureiri Decaisine - S. loureiri Decaisne. - Saururus loureiri Decne. - Spathium chinense Loureiro, Fl. Cochinch. 217. 1790 - S. cumingii C. de Candolle - Saururopsis cumingii C. DC. - Saururus cernuus Thunberg (1784), not Linnaeus (1753) - Ještěrorep čínský - Lizard's Tail - ještěrkovec nící - Water-dragon - Swamp Root

Silybum marianum - Milk thistle - Ostropestřec mariánský [1] [2] [10]

  • Hepatoprotektivní u thioacetamide-induced hepatotoxicity in rat [2]
    • Due to the presence of flavonoids and their antioxidant effects [2]
      • Anti-lipid peroxidative [2]
        • Increasing the activity of enzyme:
          • Superoxide dismutase and peroxidase
          • Concentration of glutathione
          • Peroxidase [38]
  • Immunomodulating
    • Antifibrotic [2]
    • Anti-inflammatory [2]
  • Cytoprotectant in liver disease [10]
    • Strengthens and stabilizes the cell membranes [38]
    • Inhibits the synthesis of prostaglandins associated with the lipid peroxidation [38]
    • Promotes regeneration of liver
      • Stimulation of protein synthesis [38]
      • Production of new hepatocytes [38]
  • Treatment and prevention of cancer [10]
  • Supportive treatment of Amanita phalloides poisoning [10]
  • Mild gastrointestinal distress and allergic reactions, other side effects are rare [10]
  • Oral form standardized to contain 70 - 80 % of silymarin [10]
  • Appears to be safe for up to 41 months of use [10]
  • Significant drug reactions have not been reported [10]
  • High efficacy of the drug in patients with:
    • Amanitine (Amanita phalloides poisoning - mochomůrkou)
      • Blocks the penetration of various toxins incl. amanitin into the hepatocytes
        • Prev. from cell death [38]
    • Drugs, and other toxic injuries of liver
    • Alcohol liver injury
      • Significant reduction in liver-related mortality [38]
      • Reduction in the number of patients with encephalopathy [38]
    • Viral hepatitis
    • NASH [26]
  • Efficacy of silymarin is ambiguous in patients with:
    • Carcinoma
    • Primarily biliary cirrhosis [26]

Scoparia dulcis - Scoparia dulcis var. tenuifolia Griseb. - Capraria dulcis var. coerulea Kuntze - Capraria dulcis var. albiflora Kuntze - Scoparia grandiflora - Scoparia dulcis var. typica Domin - Scoparia ternata - Scoparia purpurea Ridl. - Scoparia procumbens Jacq. - Scoparia nudicaulis Chodat & Hassl. - Gratiola micrantha Nutt. - Capraria dulcis - Gratiola micrantha - Ambulia micrantha Raf. - Vassourinha - nunco pichana - anisillo - bitterbroom - boroemia - broomweed - brum sirpi - escobilla - mastuerzo - piqui pichana - pottipooli - sweet broom - tapixava - tupixaba - licorice weed [1]

Salvia miltiorrhiza - šalvěj červenokořenná [1]

Scutellaria baicalensis - Scutellaria macrantha Fisch. - Scutellaria bardata, Scutellaria barbata D. Don - Scutellaria rivularis Wall. - scutellarin - wogonin - Baikal Skullcap - Šišák bajkalský

Schisandra chinensis - Schizandra čínská - kalanopraška [1]

Sesame oil

  • Significant protection against cypermethrin-induced oxidative stress, biochemical changes, histopathological damage and genomic DNA fragmentation in rats [34]

Simo Yin [1]

  • Chinese traditional prescriptions

Sini San [1]

  • Chinese traditional prescriptions

Soya bean

  • Essential phospholipids (EPL) in highly purified extract of polyenylphosphatidylcholine (PPC) molecules from soybean [28]
    • 1,2-dilinoleoylphosphatidylcholine (DLPC) [28]
    • Showed anti-oxidant, anti-inflammatory, anti-fibrotic, apoptosis-modulating, regenerative, membrane-repairing and -protective, cell-signaling and receptor-influencing, as well as lipid-regulating effects in intoxication models with chemicals or drugs [28]
    • Indikace:
      • Fatty liver of different origin, drug hepatotoxicity, and adjuvant in chronic viral hepatitis and hepatic coma [28]

Solanum nigrum - lilek černý [2]

  • Thioacetamide (TAA)-induced liver fibrosis in mice [2]
    • Reduced the hepatic hydroxyproline and ? -smooth muscle actin protein levels in treated mice [2]
      • Inhibited TAA-induced collagen (I), transforming growth factor-ß1 (TGF-ß1) and mRNA levels in the liver [2]
    • Reduced the degree of fibrosis [2]
  • In CCl4 - induced chronic hepatotoxicity in rats [2]
    • Lowered the CCl4-induced serum levels of hepatic enzyme markers, superoxide and hydroxyl radicals [2]
      • V.s. due to modulation on detoxifica-tion enzymes and its antioxidant and free radical sca-venger effects [2]
      • Free radical scavenging ability [2]

Stachytarpheta indica - Stachytarpheta jamaicensis Vahl. - Stachytarpheta urticaefolia (Salisb.) Sims. - Stachytarpheta angustifolia (Miller) Vahl - Stachytarpheta jabassensis H. Winkler - Verbena angustifolia Miller - mizuiro-nagabo-so - indo-nagabo-so - light-blue snakeweed aj. [4]

  • Ethanolic extracts (300mg & 600mg/kg,b.w,p.o) to the animals treated with carbon tetrachloride
    • Significant reduction of serumenzymes: Aspartate Transminase, Alanine Transminase, Alkaline Phosphatase, Total Protein, Total Billirubin [4]
    • The hepatoprotective effect of Stachytarpheta indica extract 600mg/kg was comparable with the standard drug Silymarin [4]
      • Confirmed by histopathological study - almost equal [4]

Taraxacum officinale - Dandelion - pampeliška lékařská (obecná) - smetanka lékařská

Tephrosia purpurea - Cracca purpurea - basterd indigo - hoary pea - Koželusk purpurový

Terminalia catappa - Badamia commersonii Gaertn. - Buceras catappa (L.) Hitchc.- Catappa domestica Rumph. - Juglans catappa (L.) Lour. - Myrobalanus catappa (L.) Kunte - Terminalia badamia DC. - Terminalia intermedia Bertero ex Spreng. - Terminalia latifolia Blanco - Terminalia moluccana Lam. - Terminalia myrobalana Roth - Terminalia procera Roxb. - Terminalia subcordata Humb. et Bonpl. ex Willd. - beach almond - Mandlovník mořský - vrcholák pravý [1]

Tinospora cordifolia - Guduchi - guduči - Amrita - Chebule srdčitá - Tinospora srdcolistá [1] [3] [4]

  • 20 patients of infective hepatitis
    • Relieving the symptoms
    • Normalization of altered liver functions
    • 75 % were cured
    • 5 cases (25%) improved after treatment [4]
  • Boosthost defenses
  • Decrease the incidence of septicaemia
  • Increased survival of surgical patients [4]
  • 100mg/kg/d for 5 weeks:
    • Decrease the renal damage [4]
    • Improve the fibrinogen level [4]
    • Reduce lead acetate induced endotoxaemia [4]
  • Decrease renal ischemia induced mortality [4]
  • Proven hepatoprotective activity in albino rats and goats intoxicated with CCl4 [4]
  • Hepatoprotektivní a imunomodulační vlastnosti extraktu byly zkoušeny i u obstrukční žloutenky na 30 pacientech, kteří byli rozděleni do dvou skupin.
    • 1. skupina léčena klasicky (vit. K, ATB, biliární drenáž)
    • 2. skupina navíc p.o. extrakt T. cordifolia 16 mg/kg/den [43]
    • Jaterní funkce se zlepšily u obou skupin srovnatelně po provedení drenáže ale:
      • 2. sk. normalizace fagocytických a zabíjecích funkcí neutrofilů [43]
      • Septikémie u 50% pacientů 1. sk., 0% ve 2. sk. (p < 0,05) [43]
      • Pooperační přežívání 1. sk. 40%, ve 2. sk. 92,4% (p < 0,01) [43]
    • Prokázáno podstatné zlepšení léčby při podávání extraktu T. cordifolia [43]
  • V ČR: www.heureka.cz/?h[fraze]=Tinospora+cordifolia

Trigonella foenum graecum seeds - fenugreek seeds - pískavice - řecké seno [5] [11]

  • Antioxidant status in experimental ethanol toxicity in rats byl doprovázen deplecí:
  • Aqueous extract of fenugreek seeds prevented:
    • The enzymatic leakage
    • The rise in lipid peroxidation
    • Enhanced the antioxidant potential [5]
  • Could offer a significant protection against ethanol toxicity [5]
  • Polyphenolic extract - hepatoprotektivní také, srovnatelný s ostropestřecem m. [11]
  • V ČR: www.heureka.cz/?h[fraze]=%C5%99eck%C3%A9+seno

Uncaria gambir - gambirovník trpký (Rubiaceae)

Vaccinium gaultheriifolium - Vaccinium gaultheriifolium var. gaultheriifolium - Thibaudia gaultheriifolia - Vaccinium diaphanoloma Hand.-Mazz. - Chinese blueberries - brusnice (vřesovcovité) [31]

  • Inhibiti metabolic syndrome
  • Polyphenol-rich extracts
    • Anthocyanin-rich fraction and phenolic acid-rich fraction
      • Efficiently inhibited oleic acid - induced TG accumulation in HepG2 cells [31]
    • Ethyl acetate extract
  • phenolic acids displayed good efficiency in inhibiting TG accumulation in HepG2 cells:
    • Caffeic
    • Chlorogenic
    • Ferulic
    • P-coumaric
    • Cinnamic acids [31]

Vitis thunbergii - Cissus labrusca - V. ficifolia var. thunbergii - Vitis ficifolia - Vitis heyneana subsp. ficifolia - Vitis labrusca - Vitis sieboldii - réva Thunbergova [1]

  • Taiwan
  • Druh tmavého hroznového vína

Vitis flexuosa - V. cavaleriei - V. flexuosa f. parvifolia - V. flexuosa var. chinensis - V. flexuosa var. parvifolia - V. flexuosa var. wallichii - V. parvifolia - V. purani - V. vulpina var. parvifolia - V. wallichii [1]

  • Taiwan

Viti kelungensis [1]

  • One of three common wild grapes from Taiwan [1]
  • For inflammatory disorders
    • Methanolic extract of V. kelungensis stem (VKS) strongly suppressed NO production in lipopolysaccharide (LPS) - stimulated murine macrophages [44]
  • Hepatoprotective properties [44]

Wedelia calendulacea - Wedelia chinensis - Verbesina Calendulacea, Roxb. (Asteraceae) - Solidago chinensis - Solidage chinensis - Wedelia prostrata - Wedelia chinensis (Osbeck) Merr. - Bhimra - Bhanra - Pilabhangara - Gargari - Kalsarji - Chinese Wedelia - Manjakanjunni - Kadal-kayyoni - Manjal Karisalankanni - Vedélie zvonkovitá [2] [4]

  • CCl4-induced acute hepatotoxicity in rats
    • Ethanolic extract dose-dependent reduction in CCl4-induced elevated serum enzyme activities [2]
  • Protective action in paracetamol induced liver damage by increasing serum enzyme levels
    • Lactate dehydrogenase
    • Alanine and aspartate transaminase
    • Alkaline phophatase
  • Alcoholic extract protective activity against carbon tetrachloride-induced liver injury in vivo
  • Theextract also increased the bile flow in rats suggesting a stimulation of liversecretory capacity [4]

Wilkstroemia indica - Aradon indica - wilkstromia - Tie bush - Daphne indica L. - Wikstroemia shuttleworthiana Meisn. - Wikstroemia shuttleworthii Meisn. - - Wikstroemia viridiflora Meisn. - Wikstroemia foetida - Daphne foetida - Lýkovec jedovatý (?) = Daphne mezereum - Pryšec Laurel (?) = Daphne laureola

Zanthoxylum piperitum - sansho - fagara - Japanese pepper - Japanese prickly ash - Pepř sečuánský - Žlutodřev pepřový - anýzový pepř - čínský pepř - japonský pepř - divoký pepř [13]

  • Hepatoprotective effects of glycoprotein isolated from Zanthoxylum piperitum DC fruit (ZPDC glycoprotein) [13]
  • Strong scavenging activity against DPPH, superoxide anion, and hydroxyl radicals without any pro-oxidant activity in the cell-free system [13]
  • V ČR: www.heureka.cz/?h[fraze]=japonsk%C3%BD+pep%C5%99

Zizyphus mauritiana - Ziziphus mauritiana Rhamnus jujuba L. - Rhamnus mauritiana - Ziziphus jujuba - Ziziphus aucheri - Ziziphus orthacantha - Ziziphus poiretii - Ziziphus rotundata - appeldam - aprin - baer - baher - bedara - ber - bor - Chinee apple - Chinese date - coolie plum - crabapple - dindoulier - dunk - gingeolier - Indian cherry - Indian jujube - Indian plum - jujube du pays - jujubier - liane croc chien - Malay jujube - mangustine - manzana - manzanita - masson - ma-tan - perita haitiana - phutsa - pomme surette - tao - tao nhuc - widara - yuyubi - yuyubo - Masau - Jujuba čínská (?) - čínská datle - Cicimek datlový [1]

Živočišná hepatoprotektiva

Sladkovodní mlži - freshwater clam

  • Remedy for chronic hepatitis in Asia [17]
  • Pre-treatment with the Clam Extract increased MAP and IL-10 levels and decreased AST, ALT, LDH and TNF-alpha levels after hemorrhage. [17]
  • The HE stains showed diminished organ injury in the CE groups [17]
  • Freshwater clam extract is a potential immunomodulating agent and ameliorates acute liver injury. [17]

Kuřecí maso

  • Protective effect of extract of chicken meat on restraint stress-induced liver damage in mice [3]
  • Smoothing stress and promoting antioxidative processes [33]
Další potvrzení toho, jak oběcně důležité jsou bílkoviny ve stravě pro detoxikaci, regeneraci a antioxidační ochranu... i funkci jater. Problematika bílkovin pak u selhávajících jater s hrozící enfalopatií je pak složitější problém.

Komerční hepatoprotektivní produkty - vitamíny, potravní doplňky

Picroliv

  • Effective against CCl4 induced liver injury, in vivo [3]

Liv 52

  • Effective against CCl4 induced liver injury, in vivo [3]

Složení

  • Capparis spinosa
  • Cichorium intybus
  • Solanum nigrum
  • Cassia occidentalis
  • Terminalia arjuna
  • Achillea millefolium
  • Tamarix gallica
  • Eclipta alba
  • Phyllanthus niruri
  • Berberis aristata
  • Taphanus sativus
  • Phyllanthus emblica
  • Plumbaga zeylanica
  • Boerhaavia diffusa
  • Tinospora cordifolia
  • Embelia ribes
  • Terminalia chebula
  • Fumaria officianlis [3]

LIMARIN®

  • From the active extract of the fruit of silybum marianum

Cirrhitin (by CCNOW)

  • To treat Cirrhosis of the liver

Livex

HD-03

Hepatomed

Live 100

Hepatoguard

Chlorophyllin

Xieqing Wan - Drain the Green Pill [1]

  • Chinese traditional prescriptions:
    • Fang Feng - saposhnikovia root - ledebouriella root (30g)
    • Qiang Huo - notopterygium root - chiang-huo (30g)
    • Zhi Zi - cape jasmine fruit - gardenia (30g)
    • Long Dan Cao - Chinese gentian root - gentiana root (30g)
    • Da Huang - rhubarb root and rhizome (30g)
    • Chuan Xiong - Sichuan lovage root - cnidium - chuanxiong root (30g)
    • Dang Gui - tangkuei - Chinese angelica root (30g)

Vitamíny

Kyselina listová - Vit. B9

  • Hyperhomocysteinemia induces liver injury in rat: Protective effect of folic acid supplementation [12]
  • Z toho vyplývá i protektivní efekt vit. B6 a B12 důl. v metabolismu homocysteinu

Vitamín B6

  • Marginal vitamin B-6 deficiency tended to decrease mean RBC glutathione synthesis with no effect on RBC glutathione concentration [19]

Vitamín E + Vitamín C

  • Attenuated the ethanol-induced increases in ALT and AST activity [14]
  • Significantly ameliorated liver injury for ethanol administration in hepatic lipid peroxidation [14]
  • Attenuated hepatic and plasma lipid peroxidation [14]
  • Appear to be significantly more effective than vitamin A against ethanol-mediated toxic effects during liver regeneration [14]

Minerály

Zinek

  • Zinc deficiency enhances sensitivity to carbon tetrachloride-induced hepatotoxicity in rats. [25]
  • Zn - many physiological functions
    • Immune and antioxidant functions
    • Growth and reproduction [25]
  • The degree of fibrosis was also more severe in CCl(4) (250 µL/kg)-treated rats fed a Zn-deficient diet. [25]

Fosfolipidy

Lecithiny

  • Vaječné, sojové

Preskripce hepatoprotektiv v ČR

ESSENTIALE FORTE N

  • V 1 kapsli:
    • Ethers of cholinephosphoric acid (phosphatidylcholine)
      • Polyenylphosphatidylcholine or PPC
        • Diglitseridnye holinfosfornoy acid esters of natural origin
    • Unsaturated fatty acids - 300 mg
      • Mainly linoleic (70%)
      • Linolenic acids
      • Oleic acids

FLAVOBION

  • V 1 potahované tabletě
    • Silymarinum 70 mg

LAGOSA

  • V 1 dražé:
    • Cardui mariae fructus extractum siccum 204,0 mg (150,0 mg silymarinu, přepočteného na silybin)

LEGALON 70, 140, SIL

  • 70 mg ev. 140mg de Silymarine/cp

SILYMARIN AL 50

  • V 1 dražé:
    • Cardui mariae fructus extractum siccum - suchý extrakt plodu ostropestřece marianského (35:1) 68,03 do 75,19 mg
      • (odpovídá 50 mg silymarinum, přepočteno na silibinin)

SIMEPAR

  • V 1 tobolce:
Takže já bych považovala za smysluplnou kombinaci:
  • Essentiale forte N + Simepar

Další dohledané hepatoprotektivně působící látky

  • Glycyrrhizin
  • Catechin + -
  • Saikosaponins
  • Curcumin
  • Gomosin
  • Acetylbergenin
  • Kolaviron
Literatura:

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[3] Journal of Environmental Biology, April, 2007, [Internet]. [citován 2012 říj 1]. Available z: www.himalayahealthcare.com/pdf_files/liv277.pdf
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O úroveň výše

Poslední aktualizace: 7. 9. 2013 17:17:27